Pbd2 QTL Detail

Summary

• Symbol
  Pbd2
• Name
  peak bone density 2
• Synonyms
  Cti1

• Feature Type
  QTL
• IDs
  MGI:1345613
  NCBI Gene: 109445
• Candidate Genes
  1 Gene

Location &
Maps

• Sequence Map
  Chr13:17189508-38947406 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 13, 12.94 cM (cM position of peak correlated region/marker)
• Mapping Data
  4 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotypes from 2 alleles in 1 genetic background
  4 phenotype references
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  109445

References

• Summaries
  All 5

  Phenotypes 4
• Earliest
  J:52867 Shimizu M, et al., Identification of peak bone mass QTL in a spontaneously osteoporotic mouse strain. Mamm Genome. 1999 Feb;10(2):81-7
• Latest
  J:115910 Nakanishi R, et al., Secreted frizzled-related protein 4 is a negative regulator of peak BMD in SAMP6 mice. J Bone Miner Res. 2006 Nov;21(11):1713-21

Candidate Genes for Pbd2:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Bmp6	Chr13:38529098-38684283 (+)	J:77538	The authors report the construction of a reciprocal congenic strain, P2.P6-Pbd2. Strains SAMP6 and SAMP2 were used as the donor and recipient strains, respectively. Whereas Pbd2 is a QTL locus defined by bone mass. The Congenic strain carries a SAMP6-derived mouse Chromosome 13 osteoporosis susceptible interval within the SAMP2-derived osteoporosis resistance background. The Interval could be defined as being contained within proximal marker D13Mit303 and distal marker D13Mit177. Within this region gene Bmp6 resides which is suggested as a candidate gene for Pbd2.