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Mars1 Gene Detail
Summary
  • Symbol
    Mars1
  • Name
    methionine-tRNA synthetase 1
  • Synonyms
    Mars, methionine tRNA ligase, methionyl-tRNA synthetase, MetRS
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345633
    NCBI Gene: 216443
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127132090-127147655 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 74.50 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    488 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345633
 protein coding gene Chr10:127132090-127147655 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017817
 protein coding gene Chr10:130886587-130902092 (-)
A/J MGP_AJ_G0017792
 protein coding gene Chr10:125641580-125657031 (-)
AKR/J MGP_AKRJ_G0017755
 protein coding gene Chr10:129357618-129373055 (-)
BALB/cJ MGP_BALBcJ_G0017756
 protein coding gene Chr10:126053380-126069529 (-)
C3H/HeJ MGP_C3HHeJ_G0017580
 protein coding gene Chr10:129508782-129524327 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018211
 protein coding gene Chr10:135322419-135339620 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015891
 protein coding gene Chr10:119650224-119665964 (-)
CAST/EiJ MGP_CASTEiJ_G0017140
 protein coding gene Chr10:130167514-130183543 (-)
CBA/J MGP_CBAJ_G0017549
 protein coding gene Chr10:140773915-140789182 (-)
DBA/2J MGP_DBA2J_G0017655
 protein coding gene Chr10:124734053-124749506 (-)
FVB/NJ MGP_FVBNJ_G0017650
 protein coding gene Chr10:123674664-123690748 (-)
LP/J MGP_LPJ_G0017729
 protein coding gene Chr10:131456775-131473521 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017678
 protein coding gene Chr10:143477400-143492876 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018251
 protein coding gene Chr10:129422318-129437871 (-)
PWK/PhJ MGP_PWKPhJ_G0016925
 protein coding gene Chr10:124937192-124953035 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016717
 protein coding gene Chr10:128461184-128476267 (-)
WSB/EiJ MGP_WSBEiJ_G0017201
 protein coding gene Chr10:129652516-129670900 (-)



Homology
more
  • Human Ortholog
    MARS1, methionyl-tRNA synthetase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MARS1, methionyl-tRNA synthetase 1
  • Synonyms
    CMT2U, ILFS2, ILLD, MARS, METRS, MRS, MTRNS, SPG70, TTD9
  • Links
    NCBI Gene ID: 4141
    neXtProt AC: NX_P56192
    UniProt: P56192

  • Chr Location
    12q13.3; chr12:57475445-57517569 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human MARS1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    33
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    802
  • Tissues
    95
  • cDNA Data
    124
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 216443 NCBI Gene Model | MGI Sequence Detail 15566 C57BL/6J ±  kb
transcript NM_001171582 RefSeq | MGI Sequence Detail 2972 C57BL/6  
polypeptide Q68FL6 UniProt | EBI | MGI Sequence Detail 902 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010190 methionine--tRNA ligase, cytoplasmic
    (term hierarchy)
  • EC
    6.1.1.10
  • InterPro Domains
    IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
    IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
    IPR004046 Glutathione S-transferase, C-terminal
    IPR036282 Glutathione S-transferase, C-terminal domain superfamily
    IPR010987 Glutathione S-transferase, C-terminal-like
    IPR041598 Methionine--tRNA ligase, N-terminal
    IPR023458 Methionine-tRNA ligase, type 1
    IPR033911 Methioninyl-tRNA synthetase core domain
    IPR015413 Methionyl/Leucyl tRNA synthetase
    IPR014758 Methionyl-tRNA synthetase
    IPR041872 Methionyl-tRNA synthetase, anticodon-binding domain
    IPR029038 Methionyl-tRNA synthetase, Zn-domain
    IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
    IPR009068 uS15/NS1, RNA-binding domain superfamily
    IPR000738 WHEP-TRS domain
  • GlyGen
    Q68FL6 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 126
    Genomic 1
    cDNA 124
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:6368867
References
more
  • Summaries
    All 45
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 14
  • Earliest
    J:57108 Ubeda M, et al., CHOP/GADD153 and methionyl-tRNA synthetase (MetRS) genes overlap in a conserved region that controls mRNA stability. Biochem Biophys Res Commun. 1999 Aug 19;262(1):31-8
  • Latest
    J:349721 Borisova E, et al., Protein translation rate determines neocortical neuron fate. Nat Commun. 2024 Jun 7;15(1):4879
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory