About   Help   FAQ
Coro1a Gene Detail
Summary
  • Symbol
    Coro1a
  • Name
    coronin, actin binding protein 1A
  • Synonyms
    Clabp, coronin 1, Lmb3, p57
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345961
    NCBI Gene: 12721
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126298946-126303925 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.25 cM, cytoband F3
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    188 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345961
 protein coding gene Chr7:126298945-126306959 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032994
 protein coding gene Chr7:130986959-130994973 (-)
A/J MGP_AJ_G0032977
 protein coding gene Chr7:127523280-127531284 (-)
AKR/J MGP_AKRJ_G0032909
 protein coding gene Chr7:130755717-130763727 (-)
BALB/cJ MGP_BALBcJ_G0032982
 protein coding gene Chr7:127179202-127187212 (-)
C3H/HeJ MGP_C3HHeJ_G0032692
 protein coding gene Chr7:130688607-130696463 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033488
 protein coding gene Chr7:136088156-136096219 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030460
 protein coding gene Chr7:128715247-128723322 (-)
CAST/EiJ MGP_CASTEiJ_G0032021
 protein coding gene Chr7:122469369-122477357 (-)
CBA/J MGP_CBAJ_G0032665
 protein coding gene Chr7:140667174-140677610 (-)
DBA/2J MGP_DBA2J_G0032817
 protein coding gene Chr7:125499222-125507205 (-)
FVB/NJ MGP_FVBNJ_G0032770
 protein coding gene Chr7:125345577-125353591 (-)
LP/J MGP_LPJ_G0032911
 protein coding gene Chr7:132454925-132462939 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032802
 protein coding gene Chr7:141849413-141857421 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033507
 protein coding gene Chr7:129763774-129771621 (-)
PWK/PhJ MGP_PWKPhJ_G0031728
 protein coding gene Chr7:118488817-118496848 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031574
 protein coding gene Chr7:116606755-116614720 (-)
WSB/EiJ MGP_WSBEiJ_G0032133
 protein coding gene Chr7:130744418-130752457 (-)



Homology
more
  • Human Ortholog
    CORO1A, coronin 1A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CORO1A, coronin 1A
  • Synonyms
    CLABP, CLIPINA, HCORO1, IMD8, p57, TACO
  • Links
    NCBI Gene ID: 11151
    neXtProt AC: NX_P31146
    UniProt: P31146

  • Chr Location
    16p11.2; chr16:30182827-30189076 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Coro1a mouse models; 1 with human CORO1A associations

Human Disease Mouse Models
      
IDs
 View 4 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 7 alleles in 11 genetic backgrounds
    4 phenotypes from multigenic genotypes
    75 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null or hypomorph alleles of this gene display lower peripheral T cell counts resulting from defects in T cell migration and increased rates of apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    88
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    896
  • Tissues
    56
  • cDNA Data
    126
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12721 NCBI Gene Model | MGI Sequence Detail 4980 C57BL/6J ±  kb
    transcript NM_001412248 RefSeq | MGI Sequence Detail 1734 ZRU/MplStud  
    polypeptide O89053 UniProt | EBI | MGI Sequence Detail 461 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 132
      Genomic 1
      cDNA 127
      Primer pair 2
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1203736, MGI:1278331
    References
    more
    • Summaries
      All 120
      Developmental Gene Expression 9
      Diseases 4
      Gene Ontology 14
      Phenotypes 75
    • Earliest
      J:141679 Yagi H, et al., Immune deficiency of cataract Shionogi (CTS) mouse. II. Impaired in vivo T cell-mediated immune response. Immunol Invest. 1990 Oct-Dec;19(5-6):493-505
    • Latest
      J:349484 Henis M, et al., The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation. Sci Adv. 2024 Apr 12;10(15):eadf7001
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory