Tlk2 MGI Mouse Gene Detail - MGI:1346023 - tousled-like kinase 2 (Arabidopsis)

Symbol

Tlk2
Name

tousled-like kinase 2 (Arabidopsis)
Synonyms

4933403M19Rik, PKUalpha, protein kinase U-alpha

Feature Type

protein coding gene
IDs

MGI:1346023
NCBI Gene: 24086
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:105069633-105174785 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 68.61 cM
Mapping Data

1 experiment

SNPs within 2kb

2015 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346023	protein coding gene	Chr11:105066869-105174785 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019283	protein coding gene	Chr11:108399010-108509935 (+)
A/J	MGP_AJ_G0019251	protein coding gene	Chr11:103777383-103883043 (+)
AKR/J	MGP_AKRJ_G0019220	protein coding gene	Chr11:106912937-107020071 (+)
BALB/cJ	MGP_BALBcJ_G0019225	protein coding gene	Chr11:104198676-104303074 (+)
C3H/HeJ	MGP_C3HHeJ_G0019034	protein coding gene	Chr11:107196870-107304266 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019675	protein coding gene	Chr11:111767365-111878231 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017300	protein coding gene	Chr11:101119925-101221035 (+)
CAST/EiJ	MGP_CASTEiJ_G0018587	protein coding gene	Chr11:108239387-108352923 (+)
CBA/J	MGP_CBAJ_G0019003	protein coding gene	Chr11:116397166-116515332 (+)
DBA/2J	MGP_DBA2J_G0019115	protein coding gene	Chr11:103270050-103374767 (+)
FVB/NJ	MGP_FVBNJ_G0019106	protein coding gene	Chr11:102781494-102887494 (+)
LP/J	MGP_LPJ_G0019185	protein coding gene	Chr11:108864128-108982164 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019136	protein coding gene	Chr11:115666273-115787903 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019712	protein coding gene	Chr11:107386673-107497371 (+)
PWK/PhJ	MGP_PWKPhJ_G0018352	protein coding gene	Chr11:104353048-104462572 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018143	protein coding gene	Chr11:107137451-107248177 (+)
WSB/EiJ	MGP_WSBEiJ_G0018638	protein coding gene	Chr11:107351089-107461487 (+)

Human Ortholog

TLK2, tousled like kinase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TLK2, tousled like kinase 2
Synonyms

HsHPK, MRD57, PKU-ALPHA
Links

HGNC:11842

NCBI Gene ID: 11011

neXtProt AC: NX_Q86UE8

UniProt: Q86UE8
Chr Location

17q23.2; chr17:62458658-62615481 (+) GRCh38

MGI Vertebrate Homology

Tlk2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TLK2
Gene Tree

Tlk2

Diseases

1 with human TLK2 associations

				Human Disease	Mouse Models
				autosomal dominant intellectual developmental disorder IDs autosomal dominant intellectual developmental disorder DOID:0060307 OMIM:PS156200 ORDO:178469

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

18 phenotypes from 4 alleles in 3 genetic backgrounds
4 phenotypes from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

51
Endonuclease-mediated

2
Gene trapped

42
Targeted

7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

71 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous deletion of this gene causes late embryonic lethality due to placental failure. Observed phenotypes include a small, hypocellular and poorly vascularized placenta with a disorganized labyrinth, and reduced numbers of syncytiotrophoblast, spongiotrophoblast and trophoblastic giant cells.

less

All GO Annotations

59
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

12
cDNA Data

135
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tlk2

less

All Sequences

109
RefSeq

36
UniProt

9
CCDS

CCDS36356.2, CCDS48954.1, CCDS79062.1, CCDS79063.1

Ensembl

ENSMUSG00000020694 (Evidence)
NCBI Gene

24086

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020694	Ensembl Gene Model \| MGI Sequence Detail	105153	C57BL/6J	± kb
transcript	ENSMUST00000106941	Ensembl \| MGI Sequence Detail	3699	Not Applicable
polypeptide	ENSMUSP00000102554	Ensembl \| MGI Sequence Detail	750	Not Applicable

less

UniProt

9 Sequences
Protein Ontology

PR:000016378 serine/threonine-protein kinase tousled-like 2

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

less

All nucleic 136

cDNA 136

Microarray probesets 9

less

MGI:1918299

Summaries

All 46

Developmental Gene Expression 3

Gene Ontology 10

Phenotypes 14
Earliest

J:53339 Shalom S, et al., Tlk, a novel evolutionarily conserved murine serine threonine kinase, encodes multiple testis transcripts. Mol Reprod Dev. 1999 Apr;52(4):392-405
Latest

J:351320 Lin HY, et al., The TLK-ASF1 histone chaperone pathway plays a critical role in IL-1beta-mediated AML progression. Blood. 2024 Jun 27;143(26):2749-2762

TSS for Tlk2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105426	Chr11:105069546-105069563 (+)	-78 bp
Tssr105427	Chr11:105069591-105069597 (+)	-39 bp
Tssr105428	Chr11:105072372-105072424 (+)	2,765 bp
Tssr105429	Chr11:105072463-105072489 (+)	2,843 bp
Tssr105430	Chr11:105072684-105072718 (+)	3,068 bp
Tssr105431	Chr11:105081630-105081634 (+)	11,999 bp
Tssr105432	Chr11:105131207-105131227 (+)	61,584 bp
Tssr105433	Chr11:105134997-105135005 (+)	65,368 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24