Tshz1 MGI Mouse Gene Detail - MGI:1346031 - teashirt zinc finger family member 1

Symbol

Tshz1
Name

teashirt zinc finger family member 1
Synonyms

5730407I04Rik, D18Bwg1409e, Mtsh1, NY-CO-33, Sdccag33, teashirt1, Tsh1

Feature Type

protein coding gene
IDs

MGI:1346031
NCBI Gene: 110796
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr18:84029752-84105831 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 57.53 cM
Mapping Data

3 experiments

SNPs within 2kb

1708 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346031	protein coding gene	Chr18:84029752-84105833 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024604	protein coding gene	Chr18:85146075-85223953 (-)
A/J	MGP_AJ_G0024571	protein coding gene	Chr18:81398545-81473516 (-)
AKR/J	MGP_AKRJ_G0024542	protein coding gene	Chr18:83821097-83895543 (-)
BALB/cJ	MGP_BALBcJ_G0024569	protein coding gene	Chr18:81588568-81664254 (-)
C3H/HeJ	MGP_C3HHeJ_G0024338	protein coding gene	Chr18:83943920-84018777 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025016	protein coding gene	Chr18:87261623-87341128 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022447	protein coding gene	Chr18:80108487-80183674 (-)
CAST/EiJ	MGP_CASTEiJ_G0023811	protein coding gene	Chr18:84273920-84354252 (-)
CBA/J	MGP_CBAJ_G0024308	protein coding gene	Chr18:90402948-90478173 (-)
DBA/2J	MGP_DBA2J_G0024438	protein coding gene	Chr18:80919307-80993777 (-)
FVB/NJ	MGP_FVBNJ_G0024404	protein coding gene	Chr18:80241959-80319149 (-)
LP/J	MGP_LPJ_G0024522	protein coding gene	Chr18:84942063-85024135 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024434	protein coding gene	Chr18:91632882-91711426 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025065	protein coding gene	Chr18:84015793-84091954 (-)
PWK/PhJ	MGP_PWKPhJ_G0023556	protein coding gene	Chr18:81307188-81384304 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023362	protein coding gene	Chr18:84055058-84139721 (-)
WSB/EiJ	MGP_WSBEiJ_G0023873	protein coding gene	Chr18:83979419-84056827 (-)

Human Ortholog

TSHZ1, teashirt zinc finger homeobox 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TSHZ1, teashirt zinc finger homeobox 1
Synonyms

CAA, NY-CO-33, SDCCAG33, TSH1
Links

HGNC:10669

NCBI Gene ID: 10194

neXtProt AC: NX_Q6ZSZ6

UniProt: Q6ZSZ6
Chr Location

18q22.3; chr18:75210755-75289950 (+) GRCh38

MGI Vertebrate Homology

Tshz1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TSHZ1
Gene Tree

Tshz1

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Phenotype Summary

34 phenotypes from 4 alleles in 5 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Targeted

7
Transposon induced

1
Genomic Mutations

1 involving Tshz1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

52 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a null allele die shortly after birth of respiratory distress, have defects in soft palate formation, have altered axial skeleton and have middle ear defects.

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All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1077
Tissues

123
cDNA Data

83
Literature Summary

38

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA TSHZ1

ZFIN tshz1

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All Sequences

59
RefSeq

13
UniProt

3
CCDS

CCDS37876.1, CCDS89292.1

Ensembl

ENSMUSG00000046982 (Evidence)
NCBI Gene

110796

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046982	Ensembl Gene Model \| MGI Sequence Detail	76080	C57BL/6J	± kb
transcript	ENSMUST00000060303	Ensembl \| MGI Sequence Detail	5656	Not Applicable
polypeptide	ENSMUSP00000089388	Ensembl \| MGI Sequence Detail	1084	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016725 teashirt homolog 1

(term hierarchy)
InterPro Domains

IPR001356 Homeobox domain

IPR009057 Homeobox-like domain superfamily

IPR027008 Teashirt family

IPR013087 Zinc finger C2H2-type

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All nucleic 90

cDNA 84

Primer pair 3

Other 3

Microarray probesets 5

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MGD-MRK-33960, MGI:106268, MGI:1917748

Summaries

All 71

Developmental Gene Expression 38

Gene Ontology 6

Phenotypes 10
Earliest

J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
Latest

J:354191 Kc R, et al., Multimodal Hox5 activity generates motor neuron diversity. Commun Biol. 2024 Sep 17;7(1):1166

TSS for Tshz1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154126	Chr18:84105827-84105841 (-)	-3 bp
Tssr154124	Chr18:84104574-84104616 (-)	1,236 bp
Tssr154123	Chr18:84104537-84104565 (-)	1,280 bp
Tssr154122	Chr18:84104504-84104528 (-)	1,315 bp
Tssr154121	Chr18:84104382-84104394 (-)	1,443 bp
Tssr154120	Chr18:84104095-84104116 (-)	1,725 bp
Tssr154119	Chr18:84076220-84076237 (-)	29,602 bp
Tssr154118	Chr18:84055521-84055526 (-)	50,307 bp
Tssr154117	Chr18:84030487-84030521 (-)	75,327 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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