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Gdf15 Gene Detail
Summary
  • Symbol
    Gdf15
  • Name
    growth differentiation factor 15
  • Synonyms
    macrophage inhibiting cytokine-1, MIC-1, NAG-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346047
    NCBI Gene: 23886
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:71082043-71085106 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.15 cM, cytoband C1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    178 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346047
 protein coding gene Chr8:71082043-71085106 (-)
129S1/SvImJ ENSMUSG00200027964
 protein coding gene Chr8:65879214-65882278 (-)
A/J ENSMUSG00195013571
 protein coding gene Chr8:66212879-66215942 (-)
AKR/J ENSMUSG00220021192
 protein coding gene Chr8:66124659-66127723 (-)
BALB/cJ ENSMUSG00180024846
 protein coding gene Chr8:65855635-65858698 (-)
C3H/HeJ ENSMUSG00175021156
 protein coding gene Chr8:66135562-66138625 (-)
C57BL/6NJ ENSMUSG00215034611
 protein coding gene Chr8:65815356-65818419 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031156
 protein coding gene Chr8:62846848-62849887 (-)
CAST/EiJ ENSTCUG00005039428
 protein coding gene Chr8:65610654-65613722 (-)
CBA/J ENSMUSG00210030222
 protein coding gene Chr8:65901129-65904193 (-)
DBA/2J ENSMUSG00185012840
 protein coding gene Chr8:72060734-72063797 (-)
FVB/NJ ENSMUSG00205036946
 protein coding gene Chr8:65405356-65408420 (-)
JF1/MsJ ENSUMUG00000034842
 protein coding gene Chr8:74341165-74344228 (-)
LP/J ENSMUSG00230029747
 protein coding gene Chr8:75672282-75675346 (-)
NOD/ShiLtJ ENSMUSG00190024387
 protein coding gene Chr8:65822480-65825543 (-)
NZO/HlLtJ ENSMUSG00225047651
 protein coding gene Chr8:79081438-79084502 (-)
PWK/PhJ ENSLUMG00010030844
 protein coding gene Chr8:65798273-65801333 (-)
SPRET/EiJ ENSMSPG00010035592
 protein coding gene Chr8:67484725-67487781 (-)
WSB/EiJ ENSIUOG00005023870
 protein coding gene Chr8:66692222-66695285 (-)



Homology
more
  • Human Ortholog
    GDF15, growth differentiation factor 15
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GDF15, growth differentiation factor 15
  • Synonyms
    GDF-15, HG, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB
  • Links
    NCBI Gene ID: 9518
    UniProt: Q99988

  • Chr Location
    19p13.11; chr19:18374731-18389176 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotypes from multigenic genotypes
    88 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice showed no obvious major abnormalities, but exhibit progressive postnatal losses of spinal, facial, and trigeminal motoneurons, accelerated thrombus formation following injury, and decreased bleeding times.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    72
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    630
  • Tissues
    30
  • cDNA Data
    10
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23886 NCBI Gene Model | MGI Sequence Detail 3064 C57BL/6J ±  kb
    transcript NM_001330687 RefSeq | MGI Sequence Detail 1381 C57BL/6  
    polypeptide Q9Z0J7 UniProt | EBI | MGI Sequence Detail 303 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 1
      cDNA 10
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 194
      Developmental Gene Expression 14
      Gene Ontology 25
      Phenotypes 88
    • Earliest
      J:57452 Bottner M, et al., Characterization of the rat, mouse, and human genes of growth/differentiation factor-15/ macrophage inhibiting cytokine-1 (GDF-15/MIC-1). Gene. 1999 Sep 3;237(1):105-11
    • Latest
      J:391329 Duan CH, et al., Loss of Echs1 in neural stem and progenitor cells impairs neurogenesis via ER stress activation and lipid metabolic reprogramming. Nat Commun. 2026 Jul 1;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory