Fxr2 MGI Mouse Gene Detail - MGI:1346074 - FMR1 autosomal homolog 2

Symbol

Fxr2
Name

FMR1 autosomal homolog 2
Synonyms

Fxr2h

Feature Type

protein coding gene
IDs

MGI:1346074
NCBI Gene: 23879
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:69523816-69544123 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.86 cM
Mapping Data

1 experiment

SNPs within 2kb

410 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346074	protein coding gene	Chr11:69523788-69544123 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018542	protein coding gene	Chr11:70087745-70110240 (+)
A/J	MGP_AJ_G0018510	protein coding gene	Chr11:67448369-67469047 (+)
AKR/J	MGP_AKRJ_G0018479	protein coding gene	Chr11:69457812-69478092 (+)
BALB/cJ	MGP_BALBcJ_G0018482	protein coding gene	Chr11:67758714-67779034 (+)
C3H/HeJ	MGP_C3HHeJ_G0018295	protein coding gene	Chr11:69478515-69498655 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018933	protein coding gene	Chr11:72210905-72231150 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016578	protein coding gene	Chr11:64370169-64388202 (+)
CAST/EiJ	MGP_CASTEiJ_G0017850	protein coding gene	Chr11:69724118-69750056 (+)
CBA/J	MGP_CBAJ_G0018268	protein coding gene	Chr11:75441873-75464303 (+)
DBA/2J	MGP_DBA2J_G0018377	protein coding gene	Chr11:67028162-67050963 (+)
FVB/NJ	MGP_FVBNJ_G0018367	protein coding gene	Chr11:66665416-66687196 (+)
LP/J	MGP_LPJ_G0018447	protein coding gene	Chr11:70653005-70675867 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018390	protein coding gene	Chr11:76040005-76060239 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018975	protein coding gene	Chr11:69714781-69739373 (+)
PWK/PhJ	MGP_PWKPhJ_G0017624	protein coding gene	Chr11:67677996-67700272 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017414	protein coding gene	Chr11:69530734-69555038 (+)
WSB/EiJ	MGP_WSBEiJ_G0017904	protein coding gene	Chr11:69388686-69412596 (+)

Human Ortholog

FXR2, FMR1 autosomal homolog 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FXR2, FMR1 autosomal homolog 2
Synonyms

FMR1L2, FXR2P
Links

HGNC:4024

NCBI Gene ID: 9513

neXtProt AC: NX_P51116

UniProt: P51116
Chr Location

17p13.1; chr17:7591230-7614897 (-) GRCh38

MGI Vertebrate Homology

Fxr2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FXR2
Gene Tree

Fxr2

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

6
Targeted

7
Genomic Mutations

2 involving Fxr2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

36 strains or lines available

Homozygotes for a targeted null mutation exhibit hyperactivity, impaired Morris water task performance, and reductions in prepulse inhibition, contextual conditioned fear, and sensitivity to heat stimulus.

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All GO Annotations

29
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

753
Tissues

31
cDNA Data

88
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

65
RefSeq

4
UniProt

4
CCDS

CCDS24901.1

Ensembl

ENSMUSG00000018765 (Evidence)
NCBI Gene

23879

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018765	Ensembl Gene Model \| MGI Sequence Detail	20308	C57BL/6J	± kb
transcript	ENSMUST00000247847	Ensembl \| MGI Sequence Detail	2951	Not Applicable
polypeptide	ENSMUSP00000159533	Ensembl \| MGI Sequence Detail	749	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000003391 RNA-binding protein FXR2

(term hierarchy)
InterPro Domains

IPR008395 Agenet-like domain

IPR041560 FMR1, tudor domain

IPR040148 Fragile X messenger ribonucleoprotein 1

IPR022034 Fragile X messenger ribonucleoprotein 1-like, C-terminal core

IPR032172 Fragile X-related protein 1, C-terminal region 1

IPR004087 K Homology domain

IPR004088 K Homology domain, type 1

IPR036612 K Homology domain, type 1 superfamily

IPR047421 RNA-binding protein FXR2, first Tudor-like Agenet domain

IPR047422 RNA-binding protein FXR2, first type I K homology domain

IPR047420 RNA-binding protein FXR2, second Tudor-like Agenet domain

IPR047424 RNA-binding protein FXR2, second type I K homology domain

IPR040472 Synaptic functional regulator FMRP, KH0 domain
GlyGen

Q9WVR4 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 90

Genomic 1

cDNA 88

Primer pair 1

Microarray probesets 3

Summaries

All 68

Developmental Gene Expression 6

Gene Ontology 10

Phenotypes 29
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fxr2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102491	Chr11:69523753-69523828 (+)	-25 bp
Tssr102492	Chr11:69523868-69523879 (+)	58 bp
Tssr102493	Chr11:69524082-69524110 (+)	280 bp
Tssr102494	Chr11:69524571-69524576 (+)	758 bp
Tssr102495	Chr11:69533612-69533614 (+)	9,797 bp
Tssr102496	Chr11:69535995-69536004 (+)	12,184 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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