Cd52 MGI Mouse Gene Detail - MGI:1346088

Symbol

Cd52
Name

CD52 antigen
Synonyms

B7, CAMPATH-1, CLS1, MB7

Feature Type

protein coding gene
IDs

MGI:1346088
NCBI Gene: 23833
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:133820849-133822384 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 66.50 cM
Mapping Data

3 experiments

SNPs within 2kb

112 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346088	protein coding gene	Chr4:133809759-133822393 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028911	protein coding gene	Chr4:136415223-136428028 (-)
A/J	MGP_AJ_G0028870	protein coding gene	Chr4:130667985-130681680 (-)
AKR/J	MGP_AKRJ_G0028822	protein coding gene	Chr4:134416592-134431002 (-)
BALB/cJ	MGP_BALBcJ_G0028893	protein coding gene	Chr4:131320083-131332509 (-)
C3H/HeJ	MGP_C3HHeJ_G0028607	protein coding gene	Chr4:134651543-134665640 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029335	protein coding gene	Chr4:141321006-141333608 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026606	protein coding gene	Chr4:123733328-123746295 (-)
CAST/EiJ	MGP_CASTEiJ_G0028040	protein coding gene	Chr4:132771273-132788645 (-)
CBA/J	MGP_CBAJ_G0028572	protein coding gene	Chr4:145031336-145048912 (-)
DBA/2J	MGP_DBA2J_G0028721	protein coding gene	Chr4:131103205-131115631 (-)
FVB/NJ	MGP_FVBNJ_G0028689	protein coding gene	Chr4:129993537-130006911 (-)
LP/J	MGP_LPJ_G0028822	protein coding gene	Chr4:136498259-136510904 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028714	protein coding gene	Chr4:149534532-149546958 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029373	protein coding gene	Chr4:134841629-134854128 (-)
PWK/PhJ	MGP_PWKPhJ_G0027760	protein coding gene	Chr4:127829062-127846763 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027586	protein coding gene	Chr4:130683952-130697738 (-)
WSB/EiJ	MGP_WSBEiJ_G0028119	protein coding gene	Chr4:135022926-135040771 (-)

Human Ortholog

CD52, CD52 molecule

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD52, CD52 molecule
Synonyms

CDW52, EDDM5, HE5
Links

HGNC:1804

NCBI Gene ID: 1043

neXtProt AC: NX_P31358

UniProt: P31358
Chr Location

1p36.11; chr1:26317958-26320523 (+) GRCh38

MGI Vertebrate Homology

Cd52 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CD52
Gene Tree

Cd52

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

2
Endonuclease-mediated

8
Gene trapped

5
Radiation induced

1
Targeted

6
Genomic Mutations

4 involving Cd52
Find Mice (IMSR)

17 strains or lines available

Mice homozygous for a null mutation are viable with no gross abnormalities and no defects in sperm development or function.

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All GO Annotations

7
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

729
Tissues

2
cDNA Data

39
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

36
RefSeq

2
UniProt

2
CCDS

CCDS38909.1

Ensembl

ENSMUSG00000000682 (Evidence)
NCBI Gene

23833

			Length	Strain/Species	Flank
genomic	23833	NCBI Gene Model \| MGI Sequence Detail	1536	C57BL/6J	± kb
transcript	NM_013706	RefSeq \| MGI Sequence Detail	531	ZRU/MplStud
polypeptide	Q64389	UniProt \| EBI \| MGI Sequence Detail	74	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001295 CAMPATH-1 antigen

(term hierarchy)
InterPro Domains

IPR026643 CAMPATH-1 antigen (CD52)
GlyGen

Q64389 1 site

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All nucleic 41

cDNA 40

Primer pair 1

Microarray probesets 3

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MGI:2140299

Summaries

All 50

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 14
Earliest

J:10835 Kubota H, et al., Identification and gene cloning of a new phosphatidylinositol-linked antigen expressed on mature lymphocytes. Down-regulation by lymphocyte activation. J Immunol. 1990 Dec 1;145(11):3924-31
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Cd52:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr43863	Chr4:133822389-133822401 (-)	-11 bp
Tssr43862	Chr4:133822343-133822370 (-)	27 bp
Tssr43861	Chr4:133821176-133821196 (-)	1,198 bp
Tssr43860	Chr4:133821111-133821122 (-)	1,267 bp
Tssr43859	Chr4:133820886-133820896 (-)	1,493 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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