Rgs7 MGI Mouse Gene Detail - MGI:1346089 - regulator of G protein signaling 7

Symbol

Rgs7
Name

regulator of G protein signaling 7

Feature Type

protein coding gene
IDs

MGI:1346089
NCBI Gene: 24012
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:174886653-175320066 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 81.11 cM
Mapping Data

3 experiments

SNPs within 2kb

12999 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346089	protein coding gene	Chr1:174886642-175320287 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016835	protein coding gene	Chr1:181147008-181585018 (-)
A/J	MGP_AJ_G0016814	protein coding gene	Chr1:173837341-174259959 (-)
AKR/J	MGP_AKRJ_G0016780	protein coding gene	Chr1:179038913-179477250 (-)
BALB/cJ	MGP_BALBcJ_G0016772	protein coding gene	Chr1:174378476-174803713 (-)
C3H/HeJ	MGP_C3HHeJ_G0016597	protein coding gene	Chr1:179641688-180085175 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017237	protein coding gene	Chr1:187167401-187579918 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014942	protein coding gene	Chr1:165193553-165588841 (-)
CAST/EiJ	MGP_CASTEiJ_G0016178	protein coding gene	Chr1:179008765-179444026 (-)
CBA/J	MGP_CBAJ_G0016571	protein coding gene	Chr1:194015953-194438783 (-)
DBA/2J	MGP_DBA2J_G0016676	protein coding gene	Chr1:172698208-173122118 (-)
FVB/NJ	MGP_FVBNJ_G0016673	protein coding gene	Chr1:170829659-171245362 (-)
LP/J	MGP_LPJ_G0016752	protein coding gene	Chr1:182329433-182786492 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016705	protein coding gene	Chr1:201199167-201677175 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017272	protein coding gene	Chr1:178821257-179252601 (-)
PWK/PhJ	MGP_PWKPhJ_G0015965	protein coding gene	Chr1:171785978-172211418 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015742	protein coding gene	Chr1:177834905-178276600 (-)
WSB/EiJ	MGP_WSBEiJ_G0016240	protein coding gene	Chr1:179006937-179444121 (-)

Human Ortholog

RGS7, regulator of G protein signaling 7

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RGS7, regulator of G protein signaling 7
Links

HGNC:10003

NCBI Gene ID: 6000

neXtProt AC: NX_P49802

UniProt: P49802
Chr Location

1q43; chr1:240767636-241357374 (-) GRCh38

MGI Vertebrate Homology

Rgs7 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RGS7
Gene Tree

Rgs7

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Phenotype Summary

11 phenotypes from 3 alleles in 3 genetic backgrounds
7 phenotypes from multigenic genotypes
1 images
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

1
Targeted

5
Genomic Mutations

2 involving Rgs7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a hypomorphic allele exhibit reduced exploration in a new environment, impaired glucose tolerance in males, and abnormal rod b-wave electrophysiology. Mice homozygous for a knock-out allele exhibit runting, delayed eye opening, and transient prolonged b-wave implicit time.

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All GO Annotations

44
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

890
Tissues

23
cDNA Data

12
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN rgs7a

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All Sequences

92
RefSeq

38
UniProt

9
CCDS

CCDS15546.1, CCDS78755.1, CCDS83644.1

Ensembl

ENSMUSG00000026527 (Evidence)
NCBI Gene

24012

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026527	Ensembl Gene Model \| MGI Sequence Detail	433414	C57BL/6J	± kb
transcript	ENSMUST00000195324	Ensembl \| MGI Sequence Detail	2209	Not Applicable
polypeptide	ENSMUSP00000141380	Ensembl \| MGI Sequence Detail	477	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000013962 regulator of G-protein signaling 7

(term hierarchy)
InterPro Domains

IPR000591 DEP domain

IPR015898 G-protein gamma-like domain

IPR036284 G-protein gamma-like domain superfamily

IPR047016 Regulator of G protein signaling 6/7/9/11

IPR047017 Regulator of G-protein signalling 6/7/9/11, DHEX domain superfamily

IPR040759 Regulator of G-protein signalling, DHEX domain

IPR016137 RGS domain

IPR036305 RGS domain superfamily

IPR044926 RGS, subdomain 2

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily
GlyGen

O54829 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 14

cDNA 12

Primer pair 2

Microarray probesets 3

Summaries

All 66

Developmental Gene Expression 2

Gene Ontology 14

Phenotypes 25
Earliest

J:53422 He W, et al., RGS9, a GTPase accelerator for phototransduction. Neuron. 1998 Jan;20(1):95-102
Latest

J:332184 Cao Y, et al., Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors. Curr Biol. 2022 Nov 21;32(22):4783-4796.e3

TSS for Rgs7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15394	Chr1:175320105-175320122 (-)	-48 bp
Tssr15393	Chr1:175320050-175320104 (-)	-11 bp
Tssr15392	Chr1:175307105-175307111 (-)	12,958 bp
Tssr15391	Chr1:175306976-175306990 (-)	13,083 bp
Tssr15390	Chr1:175281557-175281562 (-)	38,506 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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