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Psmc4 Gene Detail
Summary
  • Symbol
    Psmc4
  • Name
    proteasome (prosome, macropain) 26S subunit, ATPase, 4
  • Synonyms
    CAR interacting protein 21, CIP21, MIP224
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346093
    NCBI Gene: 23996
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:27741127-27749517 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 16.11 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    378 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346093
 protein coding gene Chr7:27741127-27749526 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031928
 protein coding gene Chr7:26798619-26807014 (-)
A/J MGP_AJ_G0031907
 protein coding gene Chr7:26122700-26131059 (-)
AKR/J MGP_AKRJ_G0031838
 protein coding gene Chr7:26813370-26822068 (-)
BALB/cJ MGP_BALBcJ_G0031913
 protein coding gene Chr7:26303487-26311846 (-)
C3H/HeJ MGP_C3HHeJ_G0031635
 protein coding gene Chr7:27179615-27188009 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032378
 protein coding gene Chr7:27652786-27661315 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029430
 protein coding gene Chr7:27269453-27277916 (-)
CAST/EiJ MGP_CASTEiJ_G0030970
 protein coding gene Chr7:20507112-20515510 (-)
CBA/J MGP_CBAJ_G0031598
 protein coding gene Chr7:28884618-28893012 (-)
DBA/2J MGP_DBA2J_G0031751
 protein coding gene Chr7:25910831-25919225 (-)
FVB/NJ MGP_FVBNJ_G0031708
 protein coding gene Chr7:26004708-26013067 (-)
LP/J MGP_LPJ_G0031832
 protein coding gene Chr7:27106531-27114925 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031743
 protein coding gene Chr7:28414228-28422622 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032408
 protein coding gene Chr7:26284822-26293103 (-)
PWK/PhJ MGP_PWKPhJ_G0030693
 protein coding gene Chr7:20929057-20935027 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030528
 protein coding gene Chr7:17299907-17308556 (-)
WSB/EiJ MGP_WSBEiJ_G0031077
 protein coding gene Chr7:26629832-26638246 (-)



Homology
more
  • Human Ortholog
    PSMC4, proteasome 26S subunit, ATPase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSMC4, proteasome 26S subunit, ATPase 4
  • Synonyms
    MIP224, RPT3, S6, TBP-7, TBP7
  • Links
    NCBI Gene ID: 5704
    neXtProt AC: NX_P43686
    UniProt: P43686

  • Chr Location
    19q13.2; chr19:39971165-39981764 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Psmc4 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 3 alleles in 2 genetic backgrounds
    3 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die as embryos. Mice heterozygous for a knock-out allele and a conditional allele activated in motor neurons develop ALS-like symptoms.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    808
  • Tissues
    29
  • cDNA Data
    169
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23996 NCBI Gene Model | MGI Sequence Detail 8391 C57BL/6J ±  kb
    transcript NM_011874 RefSeq | MGI Sequence Detail 1436 ZRU/MplStud  
    polypeptide P54775 UniProt | EBI | MGI Sequence Detail 418 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 173
      cDNA 169
      Primer pair 2
      Other 2

      Microarray probesets 5
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:57555 Choi HS, et al., A component of the 26S proteasome binds on orphan member of the nuclear hormone receptor superfamily. J Steroid Biochem Mol Biol. 1996 Jan;56(1-6 Spec No):23-30
    • Latest
      J:330970 Kiryu-Seo S, et al., Impaired disassembly of the axon initial segment restricts mitochondrial entry into damaged axons. EMBO J. 2022 Oct 17;41(20):e110486
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory