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Adamts5 Gene Detail
Summary
  • Symbol
    Adamts5
  • Name
    ADAM metallopeptidase with thrombospondin type 1 motif 5
  • Synonyms
    9530092O11Rik, ADAM-TS5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346321
    NCBI Gene: 23794
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:85655045-85698013 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 48.34 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1279 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346321
 protein coding gene Chr16:85653061-85698716 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022974
 protein coding gene Chr16:86510004-86560253 (-)
A/J MGP_AJ_G0022942
 protein coding gene Chr16:82562498-82605954 (-)
AKR/J MGP_AKRJ_G0022912
 protein coding gene Chr16:84975696-85019973 (-)
BALB/cJ MGP_BALBcJ_G0022944
 protein coding gene Chr16:83009931-83058569 (-)
C3H/HeJ MGP_C3HHeJ_G0022706
 protein coding gene Chr16:85567832-85621980 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023391
 protein coding gene Chr16:89302262-89353313 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020895
 protein coding gene Chr16:80443284-80487388 (-)
CAST/EiJ MGP_CASTEiJ_G0022228
 protein coding gene Chr16:85991621-86042350 (-)
CBA/J MGP_CBAJ_G0022675
 protein coding gene Chr16:93111066-93160708 (-)
DBA/2J MGP_DBA2J_G0022809
 protein coding gene Chr16:82429325-82471715 (-)
FVB/NJ MGP_FVBNJ_G0022784
 protein coding gene Chr16:81606873-81650055 (-)
LP/J MGP_LPJ_G0022878
 protein coding gene Chr16:86208562-86255668 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022803
 protein coding gene Chr16:97526347-97578272 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023409
 protein coding gene Chr16:85487418-85535160 (-)
PWK/PhJ MGP_PWKPhJ_G0021970
 protein coding gene Chr16:82591485-82635499 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021801
 protein coding gene Chr16:84935863-85000518 (-)
WSB/EiJ MGP_WSBEiJ_G0022276
 protein coding gene Chr16:85736948-85789586 (-)



Homology
more
  • Human Ortholog
    ADAMTS5, ADAM metallopeptidase with thrombospondin type 1 motif 5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAMTS5, ADAM metallopeptidase with thrombospondin type 1 motif 5
  • Synonyms
    ADAM-TS 11, ADAMTS-11, ADAMTS11, ADAM-TS 5, ADAM-TS5, ADAMTS-5, ADMP-2
  • Links
    NCBI Gene ID: 11096
    neXtProt AC: NX_Q9UNA0
    UniProt: Q9UNA0

  • Chr Location
    21q21.3; chr21:26917922-26967088 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ADAMTS5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 6 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele exhibit a significant reduction in cartilage degradation after induction of osteoarthritis whereas those homozygous for another show no affect.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1316
  • Tissues
    463
  • cDNA Data
    22
  • Literature Summary
    41
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23794 NCBI Gene Model | MGI Sequence Detail 42969 C57BL/6J ±  kb
    transcript NM_011782 RefSeq | MGI Sequence Detail 8104 ZRU/MplStud  
    polypeptide Q9R001 UniProt | EBI | MGI Sequence Detail 930 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 22
      Primer pair 8
      Other 3

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:1925767, MGI:2146445
    References
    more
    • Summaries
      All 123
      Developmental Gene Expression 41
      Gene Ontology 14
      Phenotypes 48
    • Earliest
      J:56831 Abbaszade I, et al., Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. J Biol Chem. 1999 Aug 13;274(33):23443-50
    • Latest
      J:348792 Mead TJ, et al., Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development. Matrix Biol. 2024 May 13;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory