Gadd45g MGI Mouse Gene Detail - MGI:1346325 - growth arrest and DNA-damage-inducible 45 gamma

Symbol

Gadd45g
Name

growth arrest and DNA-damage-inducible 45 gamma
Synonyms

CR6, OIG37

Feature Type

protein coding gene
IDs

MGI:1346325
NCBI Gene: 23882
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr13:52000714-52002504 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 26.36 cM, cytoband A5-B
Mapping Data

3 experiments

SNPs within 2kb

94 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346325	protein coding gene	Chr13:52000711-52002511 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020555	protein coding gene	Chr13:51100470-51102260 (+)
A/J	MGP_AJ_G0020509	protein coding gene	Chr13:49271591-49273381 (+)
AKR/J	MGP_AKRJ_G0020487	protein coding gene	Chr13:50673595-50675385 (+)
BALB/cJ	MGP_BALBcJ_G0020505	protein coding gene	Chr13:49461689-49463479 (+)
C3H/HeJ	MGP_C3HHeJ_G0020304	protein coding gene	Chr13:50519579-50521369 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020939	protein coding gene	Chr13:52661152-52662942 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018521	protein coding gene	Chr13:47065769-47067555 (+)
CAST/EiJ	MGP_CASTEiJ_G0019818	protein coding gene	Chr13:50477034-50482815 (+)
CBA/J	MGP_CBAJ_G0020264	protein coding gene	Chr13:54713746-54715536 (+)
DBA/2J	MGP_DBA2J_G0020387	protein coding gene	Chr13:48838401-48840191 (+)
FVB/NJ	MGP_FVBNJ_G0020366	protein coding gene	Chr13:48272170-48273960 (+)
LP/J	MGP_LPJ_G0020463	protein coding gene	Chr13:51370229-51372019 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020395	protein coding gene	Chr13:54296190-54297979 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020982	protein coding gene	Chr13:50255743-50257533 (+)
PWK/PhJ	MGP_PWKPhJ_G0019575	protein coding gene	Chr13:48759823-48762445 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019402	protein coding gene	Chr13:49146870-49149280 (+)
WSB/EiJ	MGP_WSBEiJ_G0019880	protein coding gene	Chr13:50585761-50587553 (+)

Human Ortholog

GADD45G, growth arrest and DNA damage inducible gamma

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GADD45G, growth arrest and DNA damage inducible gamma
Synonyms

CR6, DDIT2, GADD45gamma, GRP17
Links

HGNC:4097

NCBI Gene ID: 10912

neXtProt AC: NX_O95257

UniProt: O95257
Chr Location

9q22.2; chr9:89605012-89606555 (+) GRCh38

MGI Vertebrate Homology

Gadd45g stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GADD45G
Gene Tree

Gadd45g

less

Phenotype Summary

20 phenotypes from 3 alleles in 5 genetic backgrounds
15 phenotypes from multigenic genotypes
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

1
Targeted

4
Genomic Mutations

1 involving Gadd45g
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for some null alleles exhibit male to female sex reversal, abnormal T-helper 1 and NK physiology, decreased type IV hypersensitivity, altered cellular survival to osmotic stress and impaired adaptive thermogenesis.

less

All GO Annotations

21
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

987
Tissues

181
cDNA Data

67
Literature Summary

33

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA GADD45G

Xenbase gadd45g

ZFIN gadd45ga, gadd45gb.1

less

All Sequences

40
RefSeq

2
UniProt

3
CCDS

CCDS26515.1

Ensembl

ENSMUSG00000021453 (Evidence)
NCBI Gene

23882

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021453	Ensembl Gene Model \| MGI Sequence Detail	1791	C57BL/6J	± kb
transcript	ENSMUST00000021903	Ensembl \| MGI Sequence Detail	1071	Not Applicable
polypeptide	ENSMUSP00000021903	Ensembl \| MGI Sequence Detail	159	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000007789 growth arrest and DNA damage-inducible protein GADD45 gamma

(term hierarchy)
PDB

3CG6
InterPro Domains

IPR024824 Growth arrest and DNA damage-inducible protein GADD45

IPR029064 Ribosomal protein eL30-like superfamily

IPR004038 Ribosomal protein eL8/eL30/eS12/Gadd45

less

All nucleic 71

Genomic 1

cDNA 67

Primer pair 3

Microarray probesets 3

less

MGI:2145220, MGI:2145531

Summaries

All 92

Developmental Gene Expression 33

Gene Ontology 8

Phenotypes 25
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:353339 Butts JC, et al., A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain. Dev Cell. 2024 Aug 19;59(16):2171-2188.e7

TSS for Gadd45g:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119772	Chr13:52000709-52000719 (+)	0 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24