Uts2 MGI Mouse Gene Detail - MGI:1346329

Symbol

Uts2
Name

urotensin 2
Synonyms

prepro-UII, Ucn2, urotensin II precursor

Feature Type

protein coding gene
IDs

MGI:1346329
NCBI Gene: 24111
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr4:151081554-151086267 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 81.53 cM, cytoband E1
Mapping Data

1 experiment

SNPs within 2kb

121 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346329	protein coding gene	Chr4:151081554-151086267 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029160	protein coding gene	Chr4:155026220-155031032 (+)
A/J	MGP_AJ_G0029125	protein coding gene	Chr4:148507442-148512155 (+)
AKR/J	MGP_AKRJ_G0029073	protein coding gene	Chr4:152576122-152580848 (+)
BALB/cJ	MGP_BALBcJ_G0029141	protein coding gene	Chr4:149001592-149006305 (+)
C3H/HeJ	MGP_C3HHeJ_G0028862	protein coding gene	Chr4:153144781-153149498 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029590	protein coding gene	Chr4:160594922-160599635 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026836	protein coding gene	Chr4:140888567-140893255 (+)
CAST/EiJ	MGP_CASTEiJ_G0028275	protein coding gene	Chr4:150423027-150427758 (+)
CBA/J	MGP_CBAJ_G0028824	protein coding gene	Chr4:165360367-165365789 (+)
DBA/2J	MGP_DBA2J_G0028973	protein coding gene	Chr4:148584722-148589440 (+)
FVB/NJ	MGP_FVBNJ_G0028937	protein coding gene	Chr4:147727559-147733107 (+)
LP/J	MGP_LPJ_G0029063	protein coding gene	Chr4:154959367-154964073 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028964	protein coding gene	Chr4:168476781-168482617 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029622	protein coding gene	Chr4:153102503-153108251 (+)
PWK/PhJ	MGP_PWKPhJ_G0027995	protein coding gene	Chr4:144620840-144625532 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027829	protein coding gene	Chr4:147351558-147356231 (+)
WSB/EiJ	MGP_WSBEiJ_G0028355	protein coding gene	Chr4:153235269-153239984 (+)

Human Ortholog

UTS2, urotensin 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UTS2, urotensin 2
Synonyms

PRO1068, UCN2, U-II, UII
Links

HGNC:12636

NCBI Gene ID: 10911

neXtProt AC: NX_O95399

UniProt: O95399
Chr Location

1p36.23; chr1:7843083-7913249 (-) GRCh38

MGI Vertebrate Homology

Uts2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: UTS2
Gene Tree

Uts2

Diseases

2 with human UTS2 associations

				Human Disease	Mouse Models
				gestational diabetes IDs gestational diabetes DOID:11714 EFO:0004593 ICD10CM:O24.4 MESH:D016640 NCI:C34942 UMLS_CUI:C0085207
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

2
Targeted

8
Genomic Mutations

3 involving Uts2
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene leads to alterations in macrophage and hepatic cholesterol homeostasis.

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All GO Annotations

43
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

879
Tissues

36
cDNA Data

4
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase uts2

ZFIN uts2a, uts2b

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All Sequences

30
RefSeq

2
UniProt

2
CCDS

CCDS18977.1

Ensembl

ENSMUSG00000028963 (Evidence)
NCBI Gene

24111

			Length	Strain/Species	Flank
genomic	24111	NCBI Gene Model \| MGI Sequence Detail	4714	C57BL/6J	± kb
transcript	NM_011910	RefSeq \| MGI Sequence Detail	551	C57BL/6
polypeptide	Q9QZQ3	UniProt \| EBI \| MGI Sequence Detail	123	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017210 urotensin-2

(term hierarchy)
InterPro Domains

IPR001483 Urotensin II

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All nucleic 4

cDNA 4

Microarray probesets 2

Summaries

All 40

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 14
Earliest

J:57017 Coulouarn Y, et al., Cloning, sequence analysis and tissue distribution of the mouse and rat urotensin II precursors. FEBS Lett. 1999 Aug 20;457(1):28-32
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Uts2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40473	Chr4:151081538-151081545 (+)	-12 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24