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Def8 Gene Detail
Summary
  • Symbol
    Def8
  • Name
    differentially expressed in FDCP 8
  • Synonyms
    D8Ertd713e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346331
    NCBI Gene: 23854
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:124169725-124190009 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 72.10 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    789 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346331
 protein coding gene Chr8:124150266-124190009 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034256
 protein coding gene Chr8:127051598-127074967 (+)
A/J MGP_AJ_G0034236
 protein coding gene Chr8:121797193-121817970 (+)
AKR/J MGP_AKRJ_G0034163
 protein coding gene Chr8:125329586-125349820 (+)
BALB/cJ MGP_BALBcJ_G0034229
 protein coding gene Chr8:121995140-122015399 (+)
C3H/HeJ MGP_C3HHeJ_G0033940
 protein coding gene Chr8:126027921-126049668 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034749
 protein coding gene Chr8:131310650-131347120 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031691
 protein coding gene Chr8:114605466-114626140 (+)
CAST/EiJ MGP_CASTEiJ_G0033268
 protein coding gene Chr8:126125800-126154813 (+)
CBA/J MGP_CBAJ_G0033913
 protein coding gene Chr8:136118800-136145029 (+)
DBA/2J MGP_DBA2J_G0034069
 protein coding gene Chr8:120971419-121003771 (+)
FVB/NJ MGP_FVBNJ_G0034013
 protein coding gene Chr8:120134462-120155161 (+)
LP/J MGP_LPJ_G0034159
 protein coding gene Chr8:127195691-127219693 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034060
 protein coding gene Chr8:138258139-138281255 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034768
 protein coding gene Chr8:125536808-125558076 (+)
PWK/PhJ MGP_PWKPhJ_G0032969
 protein coding gene Chr8:120794113-120814624 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032809
 protein coding gene Chr8:124254908-124276451 (+)
WSB/EiJ MGP_WSBEiJ_G0033384
 protein coding gene Chr8:126279370-126301091 (+)



Homology
more
  • Human Ortholog
    DEF8, differentially expressed in FDCP 8 homolog
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEF8, differentially expressed in FDCP 8 homolog
  • Links
    NCBI Gene ID: 54849
    neXtProt AC: NX_Q6ZN54
    UniProt: Q6ZN54

  • Chr Location
    16q24.3; chr16:89948697-89968060 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    20
  • cDNA Data
    20
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 23854 NCBI Gene Model | MGI Sequence Detail 20285 C57BL/6J ±  kb
transcript NM_001414287 RefSeq | MGI Sequence Detail 3433 ZRU/MplStud  
polypeptide Q99J78 UniProt | EBI | MGI Sequence Detail 448 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000006379 differentially expressed in FDCP 8
    (term hierarchy)
  • InterPro Domains
    IPR046349 C1-like domain superfamily
    IPR047983 Differentially expressed in FDCP 8, C conserved region 1
    IPR051366 Differentially Expressed in FDCP 8 Homolog
    IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
    IPR025258 Rubicon Homology Domain
Molecular
Reagents
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  • All nucleic 25
    Genomic 1
    cDNA 23
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1289329, MGI:2142548
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:56735 Hotfilder M, et al., Def-2, -3, -6 and -8, novel mouse genes differentially expressed in the haemopoietic system. Br J Haematol. 1999 Aug;106(2):335-44
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory