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Clca1 Gene Detail
Summary
  • Symbol
    Clca1
  • Name
    chloride channel accessory 1
  • Synonyms
    Clca3, gob-5, gob5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346342
    NCBI Gene: 23844
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:144710298-144738537 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 69.26 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    888 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346342
 protein coding gene Chr3:144709578-144738537 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027956
 protein coding gene Chr3:148401122-148432460 (-)
A/J MGP_AJ_G0027915
 protein coding gene Chr3:143111419-143140289 (-)
AKR/J MGP_AKRJ_G0027881
 protein coding gene Chr3:146909461-146940448 (-)
BALB/cJ MGP_BALBcJ_G0027927
 protein coding gene Chr3:142925925-142955514 (-)
C3H/HeJ MGP_C3HHeJ_G0027657
 protein coding gene Chr3:147276259-147305702 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028370
 protein coding gene Chr3:153500832-153531352 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025709
 protein coding gene Chr3:138224635-138252197 (-)
CAST/EiJ MGP_CASTEiJ_G0027110
 protein coding gene Chr3:147235323-147265723 (-)
CBA/J MGP_CBAJ_G0027632
 protein coding gene Chr3:158823864-158852850 (-)
DBA/2J MGP_DBA2J_G0027772
 protein coding gene Chr3:142264973-142294545 (-)
FVB/NJ MGP_FVBNJ_G0027739
 protein coding gene Chr3:139683037-139711851 (-)
LP/J MGP_LPJ_G0027883
 protein coding gene Chr3:149791588-149821377 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027772
 protein coding gene Chr3:167140762-167173319 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028429
 protein coding gene Chr3:146503180-146534025 (-)
PWK/PhJ MGP_PWKPhJ_G0026833
 protein coding gene Chr3:142118995-142148906 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026661
 protein coding gene Chr3:144688195-144717558 (-)
WSB/EiJ MGP_WSBEiJ_G0027190
 protein coding gene Chr3:147454426-147484104 (-)



Homology
more
  • Human Ortholog
    CLCA1, chloride channel accessory 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLCA1, chloride channel accessory 1
  • Synonyms
    CACC, CaCC-1, CACC1, CLCRG1, GOB5, hCaCC-1, hCLCA1
  • Links
    NCBI Gene ID: 1179
    neXtProt AC: NX_A8K7I4
    UniProt: A8K7I4

  • Chr Location
    1p22.3; chr1:86468368-86500259 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CLCA1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 4 alleles in 4 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit an exacerbated mucin response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    28
  • cDNA Data
    74
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23844 NCBI Gene Model | MGI Sequence Detail 28240 C57BL/6J ±  kb
    transcript NM_017474 RefSeq | MGI Sequence Detail 2935 ZRU/MplStud  
    polypeptide Q9D7Z6 UniProt | EBI | MGI Sequence Detail 913 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 78
      cDNA 74
      Primer pair 4

      Microarray probesets 4
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 18
      Diseases 1
      Gene Ontology 10
      Phenotypes 17
    • Earliest
      J:53044 Komiya T, et al., Cloning and identification of the gene gob-5, which is expressed in intestinal goblet cells in mice. Biochem Biophys Res Commun. 1999 Feb 16;255(2):347-51
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory