Taf7 MGI Mouse Gene Detail - MGI:1346348 - TATA-box binding protein associated factor 7

Symbol

Taf7
Name

TATA-box binding protein associated factor 7
Synonyms

55kDa, Taf2f, TAFII55

Feature Type

protein coding gene
IDs

MGI:1346348
NCBI Gene: 24074
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr18:37773544-37777257 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 19.54 cM
Mapping Data

4 experiments

SNPs within 2kb

151 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346348	protein coding gene	Chr18:37773544-37777257 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024332	protein coding gene	Chr18:36043126-36046838 (-)
A/J	MGP_AJ_G0024300	protein coding gene	Chr18:34803809-34807523 (-)
AKR/J	MGP_AKRJ_G0024268	protein coding gene	Chr18:35763839-35767550 (-)
BALB/cJ	MGP_BALBcJ_G0024299	protein coding gene	Chr18:34873583-34877297 (-)
C3H/HeJ	MGP_C3HHeJ_G0024065	protein coding gene	Chr18:35827141-35830864 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024741	protein coding gene	Chr18:37334559-37338272 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022180	protein coding gene	Chr18:34823606-34827338 (-)
CAST/EiJ	MGP_CASTEiJ_G0023541	protein coding gene	Chr18:35765461-35769183 (-)
CBA/J	MGP_CBAJ_G0024035	protein coding gene	Chr18:38430648-38434362 (-)
DBA/2J	MGP_DBA2J_G0024165	protein coding gene	Chr18:34402994-34406708 (-)
FVB/NJ	MGP_FVBNJ_G0024131	protein coding gene	Chr18:34118329-34122041 (-)
LP/J	MGP_LPJ_G0024249	protein coding gene	Chr18:36118212-36121941 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024162	protein coding gene	Chr18:39717605-39721307 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024790	protein coding gene	Chr18:35618696-35622408 (-)
PWK/PhJ	MGP_PWKPhJ_G0023285	protein coding gene	Chr18:34611971-34615798 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023090	protein coding gene	Chr18:35846534-35850269 (-)
WSB/EiJ	MGP_WSBEiJ_G0023603	protein coding gene	Chr18:35516400-35520111 (-)

Human Ortholog

TAF7, TATA-box binding protein associated factor 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TAF7, TATA-box binding protein associated factor 7
Synonyms

TAF2F, TAFII55
Links

HGNC:11541

NCBI Gene ID: 6879

neXtProt AC: NX_Q15545

UniProt: Q15545
Chr Location

5q31.3; chr5:141259884-141320784 (-) GRCh38

MGI Vertebrate Homology

Taf7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TAF7
Gene Tree

Taf7

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Phenotype Summary

13 phenotypes from 2 alleles in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

2
Gene trapped

3
Targeted

9
Transgenic

1
Genomic Mutations

5 involving Taf7
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit embryonic lethality between E3.5 and E5.5. Mice homozygous for a conditional allele activated in thymocytes exhibit impaired T cell differentiation.

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All GO Annotations

70
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

749
Tissues

24
cDNA Data

57
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase taf7

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All Sequences

43
RefSeq

2
UniProt

3
CCDS

CCDS29189.1

Ensembl

ENSMUSG00000051316 (Evidence)
NCBI Gene

24074

			Length	Strain/Species	Flank
genomic	24074	NCBI Gene Model \| MGI Sequence Detail	3714	C57BL/6J	± kb
transcript	NM_175770	RefSeq \| MGI Sequence Detail	3302	C57BL/6
polypeptide	Q9R1C0	UniProt \| EBI \| MGI Sequence Detail	341	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016033 transcription initiation factor TFIID subunit 7

(term hierarchy)
InterPro Domains

IPR006751 TAFII55 protein, conserved region

IPR037817 Transcription initiation factor TFIID subunit 7
GlyGen

Q9R1C0 1 site, 1 O-linked glycan (1 site)

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All nucleic 60

Genomic 1

cDNA 57

Primer pair 2

Microarray probesets 5

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MGI:2147246, MGI:2147382

Summaries

All 61

Developmental Gene Expression 14

Gene Ontology 15

Phenotypes 13
Earliest

J:56830 Wu SY, et al., Isolation of mouse TFIID and functional characterization of TBP and TFIID in mediating estrogen receptor and chromatin transcription. J Biol Chem. 1999 Aug 13;274(33):23480-90
Latest

J:332241 Kobayashi H, et al., Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality. iScience. 2023 Jan 20;26(1):105766

TSS for Taf7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr152989	Chr18:37777268-37777279 (-)	-17 bp
Tssr152988	Chr18:37777238-37777262 (-)	7 bp
Tssr152987	Chr18:37777190-37777231 (-)	46 bp
Tssr152986	Chr18:37777174-37777189 (-)	75 bp
Tssr152985	Chr18:37777115-37777126 (-)	136 bp
Tssr152984	Chr18:37775232-37775235 (-)	2,023 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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