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Igbp1 Gene Detail
Summary
  • Symbol
    Igbp1
  • Name
    immunoglobulin (CD79A) binding protein 1
  • Synonyms
    alpha 4, p52, Pc52, Tap42
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346500
    NCBI Gene: 18518
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:99537897-99559731 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 43.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    536 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346500
 protein coding gene ChrX:99537897-99559731 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035941
 protein coding gene ChrX:96947897-96969645 (+)
A/J MGP_AJ_G0035926
 protein coding gene ChrX:96989074-97010762 (+)
AKR/J MGP_AKRJ_G0035842
 protein coding gene ChrX:99776055-99797618 (+)
BALB/cJ MGP_BALBcJ_G0035909
 protein coding gene ChrX:95742001-95764291 (+)
C3H/HeJ MGP_C3HHeJ_G0035618
 protein coding gene ChrX:97384339-97407571 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036438
 protein coding gene ChrX:99858247-99881525 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033268
 protein coding gene ChrX:94777739-94799156 (+)
CAST/EiJ MGP_CASTEiJ_G0034905
 protein coding gene ChrX:81686758-81708628 (+)
CBA/J MGP_CBAJ_G0035593
 protein coding gene ChrX:102955719-102978385 (+)
DBA/2J MGP_DBA2J_G0035747
 protein coding gene ChrX:96199481-96221406 (+)
FVB/NJ MGP_FVBNJ_G0035685
 protein coding gene ChrX:95602005-95624073 (+)
LP/J MGP_LPJ_G0035837
 protein coding gene ChrX:97932735-97954398 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035720
 protein coding gene ChrX:107480528-107502519 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036465
 protein coding gene ChrX:96664938-96688954 (+)
PWK/PhJ MGP_PWKPhJ_G0034604
 protein coding gene ChrX:79307845-79329558 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034432
 protein coding gene ChrX:82567281-82588702 (+)
WSB/EiJ MGP_WSBEiJ_G0035044
 protein coding gene ChrX:95380179-95402470 (+)



Homology
more
  • Human Ortholog
    IGBP1, immunoglobulin binding protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGBP1, immunoglobulin binding protein 1
  • Synonyms
    alpha4, ALPHA-4, IBP1, MRXS28
  • Links
    NCBI Gene ID: 3476
    neXtProt AC: NX_P78318
    UniProt: P78318

  • Chr Location
    Xq13.1; chrX:70133447-70166324 (+)  GRCh38
  • Human Ortholog
    IGBP1C, IGBP1 family member C
  • Synonyms
    IGBP1P2
  • Links
    NCBI Gene ID: 645545
    UniProt: A0A1W2PR95

  • Chr Location
    17q22; chr17:58660424-58692045 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IGBP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 4 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    14
  • cDNA Data
    20
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18518 NCBI Gene Model | MGI Sequence Detail 21835 C57BL/6J ±  kb
    transcript NM_008784 RefSeq | MGI Sequence Detail 1518 C57BL/6  
    polypeptide Q61249 UniProt | EBI | MGI Sequence Detail 340 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 2
      cDNA 23
      Primer pair 1
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-32087, MGI:105048, MGI:2147845, MGI:2147906, MGI:2148003, MGI:2148070
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 8
    • Earliest
      J:27712 Kuwahara K, et al., Identification of a 52-kDa molecule (p52) coprecipitated with the Ig receptor-related MB-1 protein that is inducibly phosphorylated by the stimulation with phorbol myristate acetate. J Immunol. 1994 Mar 15;152(6):2742-52
    • Latest
      J:353712 Sakaguchi M, et al., Phosphatase protector alpha4 (alpha4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling. Nat Commun. 2022 Oct 14;13(1):6092
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory