Sgcg MGI Mouse Gene Detail - MGI:1346524 - sarcoglycan, gamma (dystrophin-associated glycoprotein)

Symbol

Sgcg
Name

sarcoglycan, gamma (dystrophin-associated glycoprotein)
Synonyms

5430420E18Rik, gamma-SG

Feature Type

protein coding gene
IDs

MGI:1346524
NCBI Gene: 24053
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr14:61456564-61495939 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 32.27 cM, cytoband C3
Mapping Data

3 experiments

SNPs within 2kb

1390 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346524	protein coding gene	Chr14:61456555-61495939 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021438	protein coding gene	Chr14:55587104-55630434 (-)
A/J	MGP_AJ_G0021397	protein coding gene	Chr14:54379790-54419456 (-)
AKR/J	MGP_AKRJ_G0021372	protein coding gene	Chr14:56319097-56358796 (-)
BALB/cJ	MGP_BALBcJ_G0021402	protein coding gene	Chr14:54330378-54369930 (-)
C3H/HeJ	MGP_C3HHeJ_G0021180	protein coding gene	Chr14:55960767-55997420 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021841	protein coding gene	Chr14:58306274-58347933 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019381	protein coding gene	Chr14:52390090-52426209 (-)
CAST/EiJ	MGP_CASTEiJ_G0020696	protein coding gene	Chr14:52356068-52396070 (-)
CBA/J	MGP_CBAJ_G0021147	protein coding gene	Chr14:59982350-60026597 (-)
DBA/2J	MGP_DBA2J_G0021270	protein coding gene	Chr14:54044591-54084648 (-)
FVB/NJ	MGP_FVBNJ_G0021248	protein coding gene	Chr14:53472579-53513087 (-)
LP/J	MGP_LPJ_G0021344	protein coding gene	Chr14:56628799-56667085 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021277	protein coding gene	Chr14:59295315-59338605 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021864	protein coding gene	Chr14:55470453-55511426 (-)
PWK/PhJ	MGP_PWKPhJ_G0020440	protein coding gene	Chr14:50714509-50752383 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020273	protein coding gene	Chr14:51408787-51443783 (-)
WSB/EiJ	MGP_WSBEiJ_G0020749	protein coding gene	Chr14:55791113-55829849 (-)

Human Ortholog

SGCG, sarcoglycan gamma

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SGCG, sarcoglycan gamma
Synonyms

35DAG, A4, DAGA4, DMDA, DMDA1, gamma-SG, LGMD2C, LGMDR5, MAM, SCARMD2, SCG3
Links

HGNC:10809

NCBI Gene ID: 6445

neXtProt AC: NX_Q13326

UniProt: Q13326
Chr Location

13q12.12; chr13:23160508-23325162 (+) GRCh38

MGI Vertebrate Homology

Sgcg stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SGCG
Gene Tree

Sgcg

Diseases

2 with Sgcg mouse models; 2 with human SGCG associations

Human Disease

Mouse Models

autosomal recessive limb-girdle muscular dystrophy type 2C

IDs

View 2 models

limb-girdle muscular dystrophy

IDs

View 1 model

type 2 diabetes mellitus

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

3 with disease annotations

References

5 with disease annotations

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Phenotype Summary

30 phenotypes from 4 alleles in 3 genetic backgrounds
13 phenotypes from multigenic genotypes
4 images
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

2
Transgenic

2
Genomic Mutations

1 involving Sgcg
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display abnormalities in muscles and heart similar to muscular dystrophy.

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All GO Annotations

16
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

742
Tissues

16
cDNA Data

19
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sgcg

ZFIN sgcg

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All Sequences

45
RefSeq

4
UniProt

2
CCDS

CCDS27181.1

Ensembl

ENSMUSG00000035296 (Evidence)
NCBI Gene

24053

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035296	Ensembl Gene Model \| MGI Sequence Detail	39376	C57BL/6J	± kb
transcript	ENSMUST00000077954	Ensembl \| MGI Sequence Detail	3515	Not Applicable
polypeptide	ENSMUSP00000077106	Ensembl \| MGI Sequence Detail	291	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014785 gamma-sarcoglycan

(term hierarchy)
InterPro Domains

IPR006875 Sarcoglycan complex subunit protein

IPR039972 Sarcoglycan gamma/delta/zeta
GlyGen

P82348 2 sites, 1 O-linked glycan (1 site)

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All nucleic 19

cDNA 19

Microarray probesets 4

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MGI:1921755, MGI:2145683

Summaries

All 82

Developmental Gene Expression 9

Diseases 5

Gene Ontology 10

Phenotypes 35
Earliest

J:28976 Madhavan R, et al., Interactions between dystrophin glycoprotein complex proteins. Biochemistry. 1995 Sep 26;34(38):12204-9
Latest

J:355456 O'Brien JG, et al., The super-healing MRL strain promotes muscle growth in muscular dystrophy through a regenerative extracellular matrix. JCI Insight. 2024 Jan 4;9(3)

TSS for Sgcg:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129055	Chr14:61495933-61495942 (-)	1 bp
Tssr129054	Chr14:61495832-61495914 (-)	66 bp
Tssr129053	Chr14:61495439-61495463 (-)	488 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24