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Sgcd Gene Detail
Summary
  • Symbol
    Sgcd
  • Name
    sarcoglycan, delta (dystrophin-associated glycoprotein)
  • Synonyms
    delta-SG
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346525
    NCBI Gene: 24052
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:46861904-47880309 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 28.09 cM, cytoband B1.2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    27523 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346525
 protein coding gene Chr11:46787080-47880309 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018202
 protein coding gene Chr11:45861727-46989454 (-)
A/J MGP_AJ_G0018174
 protein coding gene Chr11:44064553-45149193 (-)
AKR/J MGP_AKRJ_G0018140
 protein coding gene Chr11:45383271-46503486 (-)
BALB/cJ MGP_BALBcJ_G0018143
 protein coding gene Chr11:44226013-45324344 (-)
C3H/HeJ MGP_C3HHeJ_G0017957
 protein coding gene Chr11:45414986-46530848 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018597
 protein coding gene Chr11:47218481-48373137 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016252
 protein coding gene Chr11:41977438-43022145 (-)
CAST/EiJ MGP_CASTEiJ_G0017520
 protein coding gene Chr11:45562436-46683391 (-)
CBA/J MGP_CBAJ_G0017929
 protein coding gene Chr11:49424898-50620076 (-)
DBA/2J MGP_DBA2J_G0018039
 protein coding gene Chr11:43850865-44958897 (-)
FVB/NJ MGP_FVBNJ_G0018033
 protein coding gene Chr11:43499574-44591069 (-)
LP/J MGP_LPJ_G0018111
 protein coding gene Chr11:46110862-47213781 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018057
 protein coding gene Chr11:50934625-52149222 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018636
 protein coding gene Chr11:45534480-46680350 (-)
PWK/PhJ MGP_PWKPhJ_G0017300
 protein coding gene Chr11:43951425-45373175 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017093
 protein coding gene Chr11:45423799-46449142 (-)
WSB/EiJ MGP_WSBEiJ_G0017570
 protein coding gene Chr11:45197401-46307745 (-)



Homology
more
  • Human Ortholog
    SGCD, sarcoglycan delta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SGCD, sarcoglycan delta
  • Synonyms
    35DAG, CMD1L, DAGD, LGMDR6, SGCDP, SGD, SG-delta
  • Links
    NCBI Gene ID: 6444
    neXtProt AC: NX_Q92629
    UniProt: Q92629

  • Chr Location
    5q33.2-q33.3; chr5:155727832-156767788 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Sgcd mouse models; 3 with human SGCD associations

Human Disease Mouse Models
      
IDs
 View 3 models
IDs
 View 4 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 3 alleles in 4 genetic backgrounds
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display cardiomyopathy and muscular dystrophy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    8
  • cDNA Data
    6
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 24052 NCBI Gene Model | MGI Sequence Detail 1018406 C57BL/6J ±  kb
    transcript NM_011891 RefSeq | MGI Sequence Detail 9126 ZRU/MplStud  
    polypeptide P82347 UniProt | EBI | MGI Sequence Detail 289 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000014783 delta-sarcoglycan
      (term hierarchy)
    • InterPro Domains
      IPR006875 Sarcoglycan complex subunit protein
      IPR039972 Sarcoglycan gamma/delta/zeta
    • GlyGen
      P82347 4 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 3
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 6
      Diseases 4
      Gene Ontology 12
      Phenotypes 62
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:350917 Vanhoutte D, et al., Thbs1 regulates skeletal muscle mass in a TGFbeta-Smad2/3-ATF4-dependent manner. Cell Rep. 2024 May 28;43(5):114149
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory