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Psmb8 Gene Detail
Summary
  • Symbol
    Psmb8
  • Name
    proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
  • Synonyms
    Lmp-7, Lmp7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346527
    NCBI Gene: 16913
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34417169-34420428 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346527
 protein coding gene Chr17:34416695-34420428 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023563
 protein coding gene Chr17:34199889-34204392 (+)
A/J MGP_AJ_G0023525
 protein coding gene Chr17:33039466-33043149 (+)
AKR/J MGP_AKRJ_G0023490
 protein coding gene Chr17:33424504-33428189 (+)
BALB/cJ MGP_BALBcJ_G0023529
 protein coding gene Chr17:33197303-33208712 (+)
C3H/HeJ MGP_C3HHeJ_G0023289
 protein coding gene Chr17:33774281-33778764 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023969
 protein coding gene Chr17:35491856-35498447 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021448
 protein coding gene Chr17:30529604-30533369 (+)
CAST/EiJ MGP_CASTEiJ_G0022789
 protein coding gene Chr17:33879552-33883226 (+)
CBA/J MGP_CBAJ_G0023267
 protein coding gene Chr17:36940170-36948877 (+)
DBA/2J MGP_DBA2J_G0023396
 protein coding gene Chr17:32392836-32396586 (+)
FVB/NJ MGP_FVBNJ_G0023362
 protein coding gene Chr17:32253011-32257069 (+)
LP/J MGP_LPJ_G0023473
 protein coding gene Chr17:34469315-34473764 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023385
 protein coding gene Chr17:35923317-35926992 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024012
 protein coding gene Chr17:33765285-33768986 (+)
PWK/PhJ MGP_PWKPhJ_G0022539
 protein coding gene Chr17:31325643-31331139 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022354
 protein coding gene Chr17:31718751-31722205 (+)
WSB/EiJ MGP_WSBEiJ_G0022850
 protein coding gene Chr17:33800882-33804581 (+)



Homology
more
  • Human Ortholog
    PSMB8, proteasome 20S subunit beta 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSMB8, proteasome 20S subunit beta 8
  • Synonyms
    ALDD, D6S216, D6S216E, JMP, LMP7, NKJO, PRAAS1, PSMB5i, RING10
  • Links
    NCBI Gene ID: 5696
    neXtProt AC: NX_P28062
    UniProt: P28062

  • Chr Location
    6p21.32; chr6:32840717-32844679 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PSMB8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    79 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display an essentially normal phenotype. However they have a reduced ability to process MHC class I restricted antigens.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    16
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    1
  • cDNA Data
    21
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16913 NCBI Gene Model | MGI Sequence Detail 3260 C57BL/6J ±  kb
transcript NM_010724 RefSeq | MGI Sequence Detail 1223 ZRU/MplStud  
polypeptide P28063 UniProt | EBI | MGI Sequence Detail 276 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    Genomic 3
    cDNA 21

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11822, MGD-MRK-11824, MGI:96798
References
more
  • Summaries
    All 129
    Developmental Gene Expression 3
    Gene Ontology 11
    Phenotypes 79
  • Earliest
    J:8266 Monaco JJ, et al., The LMP antigens: a stable MHC-controlled multisubunit protein complex. Hum Immunol. 1986 Apr;15(4):416-26
  • Latest
    J:357795 Ishii Y, et al., Impaired immunoproteasomal function exacerbates renal ischemia-reperfusion injury. Exp Mol Pathol. 2024 Oct 18;140:104939
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory