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Mapk10 Gene Detail
Summary
  • Symbol
    Mapk10
  • Name
    mitogen-activated protein kinase 10
  • Synonyms
    C230008H04Rik, JNK3, p493F12, Serk2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346863
    NCBI Gene: 26414
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:103056413-103359200 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 49.61 cM, cytoband E4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9021 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346863
 protein coding gene Chr5:103055814-103359200 (-)
129S1/SvImJ ENSMUSG00200006077
 protein coding gene Chr5:96781041-97084366 (-)
A/J ENSMUSG00195031075
 protein coding gene Chr5:96379866-96685320 (-)
AKR/J ENSMUSG00220034301
 protein coding gene Chr5:95831874-96139037 (-)
BALB/cJ ENSMUSG00180033391
 protein coding gene Chr5:96532071-96837510 (-)
C3H/HeJ ENSMUSG00175028905
 protein coding gene Chr5:98617510-98921145 (-)
C57BL/6NJ ENSMUSG00215012098
 protein coding gene Chr5:96446299-96749735 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027465
 protein coding gene Chr5:95773716-96062706 (-)
CAST/EiJ ENSTCUG00005021631
 protein coding gene Chr5:95763289-96055353 (-)
CBA/J ENSMUSG00210029715
 protein coding gene Chr5:97367828-97671464 (-)
DBA/2J ENSMUSG00185036413
 protein coding gene Chr5:100285277-100588619 (-)
FVB/NJ ENSMUSG00205037170
 protein coding gene Chr5:96282937-96588365 (-)
JF1/MsJ ENSUMUG00000008566
 protein coding gene Chr5:103242374-103525610 (-)
LP/J ENSMUSG00230023418
 protein coding gene Chr5:104322490-104625803 (-)
NOD/ShiLtJ ENSMUSG00190024612
 protein coding gene Chr5:96252432-96556069 (-)
NZO/HlLtJ ENSMUSG00225025600
 protein coding gene Chr5:112081392-112384708 (-)
PWK/PhJ ENSLUMG00010014575
 protein coding gene Chr5:95350952-95634077 (-)
SPRET/EiJ ENSMSPG00010023051
 protein coding gene Chr5:98270149-98567534 (-)
WSB/EiJ ENSIUOG00005028222
 protein coding gene Chr5:98966170-99270131 (-)



Homology
more
  • Human Ortholog
    MAPK10, mitogen-activated protein kinase 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAPK10, mitogen-activated protein kinase 10
  • Synonyms
    JNK3, JNK3A, p493F12, p54bSAPK, PRKM10, SAPK1b
  • Links
    NCBI Gene ID: 5602
    UniProt: P53779

  • Chr Location
    4q21.3; chr4:85990007-86594625 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MAPK10 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a normal phenotype. They are resistant to kainic acid induced seizures and show increased resistance to MPTP induced Parkinson's disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    948
  • Tissues
    182
  • cDNA Data
    19
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26414 NCBI Gene Model | MGI Sequence Detail 302788 C57BL/6J ±  kb
    transcript NM_001407592 RefSeq | MGI Sequence Detail 6874 C57BL/6  
    polypeptide Q61831 UniProt | EBI | MGI Sequence Detail 464 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 1
      cDNA 22
      Primer pair 2
      Other 1
      Antibodies 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-36125, MGI:107554, MGI:2442453
    References
    more
    • Summaries
      All 135
      Developmental Gene Expression 22
      Gene Ontology 15
      Phenotypes 64
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:382670 Bardile CF, et al., Alterations in Both Caliber and Myelination of Callosal Axons Elicited by Ubiquitous Genetic Ablation of c-Jun Amino-Terminal Kinase 3 (JNK3). J Neurochem. 2026 Jan;170(1):e70356
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/01/2026
    MGI 6.24     		The Jackson Laboratory