Mapk14 MGI Mouse Gene Detail - MGI:1346865 - mitogen-activated protein kinase 14

Symbol

Mapk14
Name

mitogen-activated protein kinase 14
Synonyms

Crk1, Csbp1, CSBP2, Mxi2, p38, p38a, p38 alpha, p38-alpha, p38alpha, p38 MAPK, p38MAPK, p38 MAP Kinase, p38 MAP kinase alpha

Feature Type

protein coding gene
IDs

MGI:1346865
NCBI Gene: 26416
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr17:28910316-28967379 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 14.85 cM
Mapping Data

4 experiments

SNPs within 2kb

295 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346865	protein coding gene	Chr17:28910303-28967380 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023448	protein coding gene	Chr17:28136812-28199737 (+)
A/J	MGP_AJ_G0023406	protein coding gene	Chr17:27193056-27250504 (+)
AKR/J	MGP_AKRJ_G0023371	protein coding gene	Chr17:27401683-27459636 (+)
BALB/cJ	MGP_BALBcJ_G0023411	protein coding gene	Chr17:27462694-27521053 (+)
C3H/HeJ	MGP_C3HHeJ_G0023172	protein coding gene	Chr17:27799638-27857111 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023853	protein coding gene	Chr17:29267687-29328560 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021328	protein coding gene	Chr17:24549043-24605388 (+)
CAST/EiJ	MGP_CASTEiJ_G0022673	protein coding gene	Chr17:27770115-27828510 (+)
CBA/J	MGP_CBAJ_G0023146	protein coding gene	Chr17:30343563-30404097 (+)
DBA/2J	MGP_DBA2J_G0023277	protein coding gene	Chr17:26741147-26798857 (+)
FVB/NJ	MGP_FVBNJ_G0023247	protein coding gene	Chr17:26570306-26627346 (+)
LP/J	MGP_LPJ_G0023355	protein coding gene	Chr17:28387013-28449274 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023265	protein coding gene	Chr17:29737152-29795886 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023895	protein coding gene	Chr17:27844935-27902402 (+)
PWK/PhJ	MGP_PWKPhJ_G0022423	protein coding gene	Chr17:25565917-25623787 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022241	protein coding gene	Chr17:25831805-25897623 (+)
WSB/EiJ	MGP_WSBEiJ_G0022735	protein coding gene	Chr17:27828591-27886715 (+)

Human Ortholog

MAPK14, mitogen-activated protein kinase 14

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAPK14, mitogen-activated protein kinase 14
Synonyms

CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, p38, p38ALPHA, PRKM14, PRKM15, RK, SAPK2A
Links

HGNC:6876

NCBI Gene ID: 1432

neXtProt AC: NX_Q16539

UniProt: Q16539
Chr Location

6p21.31; chr6:36027782-36124214 (+) GRCh38

MGI Vertebrate Homology

Mapk14 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MAPK14
Protein SuperFamily

Integrin-linked_kinase
Gene Tree

Mapk14

Diseases

4 with human MAPK14 associations

				Human Disease	Mouse Models
				colon cancer IDs colon cancer DOID:219 ICD10CM:C18 ICD9CM:153 ICD9CM:153.9 MESH:D003110 NCI:C9242 UMLS_CUI:C0007102
				colorectal carcinoma IDs colorectal carcinoma DOID:0080199 EFO:1001951 MESH:D015179 NCI:C2955 UMLS_CUI:C0009402
				nasopharynx carcinoma IDs nasopharynx carcinoma DOID:9261 DOID:8813 DOID:8814 DOID:9057 DOID:9144 DOID:9197 DOID:9229 ICD10CM:C11 ICD10CM:C11.0 ICD10CM:C11.1 ICD10CM:C11.2 ICD10CM:C11.3 ICD9CM:147 ICD9CM:147.0 ICD9CM:147.1 ICD9CM:147.2 ICD9CM:147.3 ICD9CM:147.9 MESH:D009303 NCI:C9321 OMIM:161550 OMIM:607107 ORDO:150 UMLS_CUI:C0153392 UMLS_CUI:C0153393 UMLS_CUI:C0153394 UMLS_CUI:C0153395 UMLS_CUI:C0153396 UMLS_CUI:C0238301
				rectum cancer IDs rectum cancer DOID:1993 DOID:1989 ICD10CM:C20 ICD9CM:154.1 MESH:D012004 NCI:C7418 NCI:C9382 UMLS_CUI:C0007113 UMLS_CUI:C0949022

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

90 phenotypes from 13 alleles in 16 genetic backgrounds
37 phenotypes from multigenic genotypes
6 images
173 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Endonuclease-mediated

3
Gene trapped

8
Targeted

20
Transgenic

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for various null mutations are embryonic to perinatal lethal showing multiple organ system defects. Mice homozygous for a knock-out mutation exhibit abnormal myoblast differentiation and delayed myofiber growth and maturation.

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All GO Annotations

142
GO References

56

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1006
Tissues

80
cDNA Data

174
Literature Summary

172

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mapk14

ZFIN mapk14a, mapk14b

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All Sequences

84
RefSeq

11
UniProt

5
CCDS

CCDS28583.1, CCDS50048.1, CCDS50049.1

Ensembl

ENSMUSG00000053436 (Evidence)
NCBI Gene

26416

			Length	Strain/Species	Flank
genomic	26416	NCBI Gene Model \| MGI Sequence Detail	57064	C57BL/6J	± kb
transcript	NM_001168514	RefSeq \| MGI Sequence Detail	3605	ZRU/MplStud
polypeptide	P47811	UniProt \| EBI \| MGI Sequence Detail	360	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000003107 mitogen-activated protein kinase 14

(term hierarchy)
PDB

1LEW, 1LEZ, 1YW2, 1YWR, 2EWA, 2GHL, 2GHM, 2GTM, 2GTN, 2OZA, 2PUU, 3P4K, 3P5K, 3P78, 3P79, 3P7A, 3P7B, 3P7C, 3PY3, 3TG1, 4KA3, 4LOO, 4LOP, 4LOQ, 4TYH, 5LAR, 5NZZ, 5O90, 5R8U, 5R8V, 5R8W, 5R8X, 5R8Y, 5R8Z, 5R90, 5R91, 5R92, 5R93, 5R94, 5R95, 5R96, 5R97, 5R98, 5R99, 5R9A, 5R9B, 5R9C, 5R9D, 5R9E, 5R9F, 5R9G, 5R9H, 5R9I, 5R9J, 5R9K, 5R9L, 5R9M, 5R9N, 5R9O, 5R9P, 5R9Q, 5R9R, 5R9S, 5R9T, 5R9U, 5R9V, 5R9W, 5R9X, 5R9Y, 5R9Z, 5RA0, 5RA1, 5RA2, 5RA3, 5RA4, 5RA5, 5RA6, 5RA7, 5RA8, 5RA9, 5UOJ, 6SO1, 6SO2, 6SO4, 6SOD, 6SOI, 6SOT, 6SOU, 6SOV, 6SP9, 6SPL, 6Y4T, 6Y4U, 6Y4V, 6Y4W, 6Y4X, 6Y6V, 6Y7W, 6Y7X, 6Y7Y, 6Y7Z, 6Y80, 6Y81, 6Y82, 6Y85, 6Y8H, 6YCU, 6YCW, 6YJC, 6YK7, 6ZWR, 7BDO, 7BDQ, 7BE4, 7BE5, 7PVU, 7Z6I, 7Z9T, 8ACM, 8ACO, 8EFJ
EC

2.7.11.24
InterPro Domains

IPR050117 Mitogen-activated protein kinase

IPR038784 Mitogen-activated protein kinase 14

IPR003527 Mitogen-activated protein (MAP) kinase, conserved site

IPR008352 Mitogen-activated protein (MAP) kinase p38-like

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily
GlyGen

P47811 1 site, 1 O-linked glycan (1 site)

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All nucleic 177

cDNA 174

Primer pair 2

Other 1

Microarray probesets 6

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MGD-MRK-2145, MGI:1338028, MGI:88502

Summaries

All 751

Developmental Gene Expression 172

Gene Ontology 56

Phenotypes 173
Earliest

J:4073 Ershler M, et al., Novel CDC2-related protein kinases produced in murine hematopoietic stem cells. Gene. 1993 Feb 28;124(2):305-6
Latest

J:348998 Wu S, et al., Shank3 deficiency elicits autistic-like behaviors by activating p38alpha in hypothalamic AgRP neurons. Mol Autism. 2024 Apr 3;15(1):14

TSS for Mapk14:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143452	Chr17:28910302-28910307 (+)	-11 bp
Tssr143453	Chr17:28910362-28910373 (+)	52 bp
Tssr143454	Chr17:28910393-28910419 (+)	90 bp
Tssr143455	Chr17:28910436-28910445 (+)	125 bp
Tssr143456	Chr17:28910764-28910799 (+)	466 bp
Tssr143457	Chr17:28911244-28911274 (+)	943 bp
Tssr143458	Chr17:28911566-28911590 (+)	1,262 bp
Tssr143459	Chr17:28911592-28911625 (+)	1,293 bp
Tssr143460	Chr17:28918588-28918592 (+)	8,274 bp
Tssr143461	Chr17:28964988-28965004 (+)	54,680 bp
Tssr143462	Chr17:28966406-28966431 (+)	56,103 bp
Tssr143463	Chr17:28966575-28966587 (+)	56,265 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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