Map2k3 MGI Mouse Gene Detail - MGI:1346868 - mitogen-activated protein kinase kinase 3

Symbol

Map2k3
Name

mitogen-activated protein kinase kinase 3
Synonyms

MAP kinase kinase 3, MKK3, Prkmk3

Feature Type

protein coding gene
IDs

MGI:1346868
NCBI Gene: 26397
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:60822880-60843637 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 37.95 cM
Mapping Data

3 experiments

SNPs within 2kb

612 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346868	protein coding gene	Chr11:60822859-60843637 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018430	protein coding gene	Chr11:60860036-60884441 (+)
A/J	MGP_AJ_G0018399	protein coding gene	Chr11:58618833-58639531 (+)
AKR/J	MGP_AKRJ_G0018369	protein coding gene	Chr11:60464919-60485691 (+)
BALB/cJ	MGP_BALBcJ_G0018370	protein coding gene	Chr11:58922760-58943888 (+)
C3H/HeJ	MGP_C3HHeJ_G0018183	protein coding gene	Chr11:60419969-60443787 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018822	protein coding gene	Chr11:62794132-62815657 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016468	protein coding gene	Chr11:55757049-55777821 (+)
CAST/EiJ	MGP_CASTEiJ_G0017740	protein coding gene	Chr11:60527804-60551201 (+)
CBA/J	MGP_CBAJ_G0018157	protein coding gene	Chr11:65521956-65546230 (+)
DBA/2J	MGP_DBA2J_G0018266	protein coding gene	Chr11:58204465-58225232 (+)
FVB/NJ	MGP_FVBNJ_G0018257	protein coding gene	Chr11:57870947-57892395 (+)
LP/J	MGP_LPJ_G0018339	protein coding gene	Chr11:61437050-61457853 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018281	protein coding gene	Chr11:66568276-66588999 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018863	protein coding gene	Chr11:60575789-60600282 (+)
PWK/PhJ	MGP_PWKPhJ_G0017513	protein coding gene	Chr11:58785163-58810366 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017303	protein coding gene	Chr11:60385605-60406273 (+)
WSB/EiJ	MGP_WSBEiJ_G0017792	protein coding gene	Chr11:60187738-60208466 (+)

Human Ortholog

MAP2K3, mitogen-activated protein kinase kinase 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAP2K3, mitogen-activated protein kinase kinase 3
Synonyms

MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2
Links

HGNC:6843

NCBI Gene ID: 5606

neXtProt AC: NX_P46734

UniProt: P46734
Chr Location

17p11.2; chr17:21284672-21315240 (+) GRCh38

MGI Vertebrate Homology

Map2k3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MAP2K3
Gene Tree

Map2k3

Diseases

2 with human MAP2K3 associations

				Human Disease	Mouse Models
				cervical cancer IDs cervical cancer DOID:4362 DOID:4361 ICD10CM:C53 ICD9CM:180 ICD9CM:180.9 MESH:D002583 NCI:C2940 NCI:C9311 OMIM:603956 UMLS_CUI:C0007847 UMLS_CUI:C0007873
				restrictive cardiomyopathy IDs restrictive cardiomyopathy DOID:397 ICD10CM:I42.5 MESH:D002313 NCI:C62798 OMIM:115210 OMIM:PS115210 ORDO:75249 UMLS_CUI:C0007196

Click on a disease name to see all genes associated with that disease.

References

2 with disease annotations

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Phenotype Summary

13 phenotypes from 2 alleles in 3 genetic backgrounds
74 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

7
Targeted

8
Transgenic

1
Genomic Mutations

3 involving Map2k3
Incidental Mutations

APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene are viable and fertile but display abnormalities in cytokine production.

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All GO Annotations

43
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

837
Tissues

122
cDNA Data

161
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

61
RefSeq

3
UniProt

7
CCDS

CCDS24804.1

Ensembl

ENSMUSG00000018932 (Evidence)
NCBI Gene

26397

			Length	Strain/Species	Flank
genomic	26397	NCBI Gene Model \| MGI Sequence Detail	20758	C57BL/6J	± kb
transcript	NM_008928	RefSeq \| MGI Sequence Detail	2177	C57BL/6
polypeptide	O09110	UniProt \| EBI \| MGI Sequence Detail	347	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000003284 dual specificity mitogen-activated protein kinase kinase 3

(term hierarchy)
PDB

1LEZ
EC

2.7.12.2
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

O09110 1 site, 1 O-linked glycan (1 site)

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All nucleic 163

cDNA 161

Primer pair 2

Microarray probesets 6

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MGI:1328353, MGI:2144511

Summaries

All 125

Developmental Gene Expression 8

Diseases 2

Gene Ontology 15

Phenotypes 74
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:334031 Crespo M, et al., Myeloid p38 activation maintains macrophage-liver crosstalk and BAT thermogenesis through IL-12-FGF21 axis. Hepatology. 2023 Mar 1;77(3):874-887

TSS for Map2k3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101929	Chr11:60821765-60821786 (+)	-1,104 bp
Tssr101930	Chr11:60821969-60821993 (+)	-899 bp
Tssr101931	Chr11:60822824-60822864 (+)	-36 bp
Tssr101932	Chr11:60822871-60822949 (+)	30 bp
Tssr101933	Chr11:60826445-60826457 (+)	3,571 bp
Tssr101934	Chr11:60832484-60832495 (+)	9,610 bp
Tssr101935	Chr11:60836062-60836067 (+)	13,185 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24