Map2k6 MGI Mouse Gene Detail - MGI:1346870 - mitogen-activated protein kinase kinase 6

Symbol

Map2k6
Name

mitogen-activated protein kinase kinase 6
Synonyms

MAP kinase kinase 6, MKK6, Prkmk6, SAPKK3

Feature Type

protein coding gene
IDs

MGI:1346870
NCBI Gene: 26399
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:110289948-110416348 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 73.60 cM, cytoband E1
Mapping Data

2 experiments

SNPs within 2kb

4342 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346870	protein coding gene	Chr11:110289928-110416348 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019345	protein coding gene	Chr11:114027286-114159835 (+)
A/J	MGP_AJ_G0019313	protein coding gene	Chr11:109090449-109217932 (+)
AKR/J	MGP_AKRJ_G0019282	protein coding gene	Chr11:112352135-112490062 (+)
BALB/cJ	MGP_BALBcJ_G0019287	protein coding gene	Chr11:109525949-109655105 (+)
C3H/HeJ	MGP_C3HHeJ_G0019096	protein coding gene	Chr11:112656369-112806706 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019737	protein coding gene	Chr11:117461918-117601753 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017360	protein coding gene	Chr11:106269380-106397495 (+)
CAST/EiJ	MGP_CASTEiJ_G0018649	protein coding gene	Chr11:113753290-113956835 (+)
CBA/J	MGP_CBAJ_G0019065	protein coding gene	Chr11:122322745-122471375 (+)
DBA/2J	MGP_DBA2J_G0019177	protein coding gene	Chr11:108572094-108701102 (+)
FVB/NJ	MGP_FVBNJ_G0019168	protein coding gene	Chr11:108021860-108148469 (+)
LP/J	MGP_LPJ_G0019247	protein coding gene	Chr11:114427467-114561600 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019199	protein coding gene	Chr11:121443850-121578820 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019774	protein coding gene	Chr11:112936468-113067173 (+)
PWK/PhJ	MGP_PWKPhJ_G0018414	protein coding gene	Chr11:109724983-109859409 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018206	protein coding gene	Chr11:112736224-112883326 (+)
WSB/EiJ	MGP_WSBEiJ_G0018701	protein coding gene	Chr11:112863736-113004306 (+)

Human Ortholog

MAP2K6, mitogen-activated protein kinase kinase 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAP2K6, mitogen-activated protein kinase kinase 6
Synonyms

MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3
Links

HGNC:6846

NCBI Gene ID: 5608

neXtProt AC: NX_P52564

UniProt: P52564
Chr Location

17q24.3; chr17:69414697-69553865 (+) GRCh38

MGI Vertebrate Homology

Map2k6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MAP2K6
Protein SuperFamily

Integrin-linked_kinase
Gene Tree

Map2k6

Diseases

5 with human MAP2K6 associations

				Human Disease	Mouse Models
				cervical cancer IDs cervical cancer DOID:4362 DOID:4361 ICD10CM:C53 ICD9CM:180 ICD9CM:180.9 MESH:D002583 NCI:C2940 NCI:C9311 OMIM:603956 UMLS_CUI:C0007847 UMLS_CUI:C0007873
				ovarian carcinoma IDs ovarian carcinoma DOID:4001 EFO:0001075 UMLS_CUI:C0677886
				Pick's disease IDs Pick's disease DOID:11870 ICD10CM:G31.01 ICD9CM:331.11 MESH:D020774 NCI:C85008 OMIM:172700 UMLS_CUI:C0236642
				progressive supranuclear palsy IDs progressive supranuclear palsy DOID:678 ICD10CM:G23.1 MESH:D013494 NCI:C85028 OMIM:601104 OMIM:609454 OMIM:610898 ORDO:683 UMLS_CUI:C0038868
				restrictive cardiomyopathy IDs restrictive cardiomyopathy DOID:397 ICD10CM:I42.5 MESH:D002313 NCI:C62798 OMIM:115210 OMIM:PS115210 ORDO:75249 UMLS_CUI:C0007196

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

2
Gene trapped

10
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for null targeted mutations of this gene are viable, grow normally and have no gross physical or histologic abnormalities.

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All GO Annotations

55
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

887
Tissues

170
cDNA Data

41
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase map2k6

ZFIN map2k6

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All Sequences

74
RefSeq

20
UniProt

7
CCDS

CCDS25592.1, CCDS88279.1

Ensembl

ENSMUSG00000020623 (Evidence)
NCBI Gene

26399

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020623	Ensembl Gene Model \| MGI Sequence Detail	126401	C57BL/6J	± kb
transcript	ENSMUST00000020949	Ensembl \| MGI Sequence Detail	2068	Not Applicable
polypeptide	ENSMUSP00000020949	Ensembl \| MGI Sequence Detail	334	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000003282 dual specificity mitogen-activated protein kinase kinase 6

(term hierarchy)
EC

2.7.12.2
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 47

cDNA 43

Primer pair 4

Microarray probesets 4

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MGD-MRK-37068, MGI:108032

Summaries

All 85

Developmental Gene Expression 14

Gene Ontology 17

Phenotypes 25
Earliest

J:36237 Han J, et al., Characterization of the structure and function of a novel MAP kinase kinase (MKK6). J Biol Chem. 1996 Feb 9;271(6):2886-91
Latest

J:334031 Crespo M, et al., Myeloid p38 activation maintains macrophage-liver crosstalk and BAT thermogenesis through IL-12-FGF21 axis. Hepatology. 2023 Mar 1;77(3):874-887

TSS for Map2k6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105712	Chr11:110289941-110289981 (+)	13 bp
Tssr105713	Chr11:110289987-110289999 (+)	45 bp
Tssr105714	Chr11:110370128-110370171 (+)	80,202 bp
Tssr105715	Chr11:110370174-110370191 (+)	80,235 bp
Tssr105716	Chr11:110370199-110370212 (+)	80,258 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24