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Map3k1 Gene Detail
Summary
  • Symbol
    Map3k1
  • Name
    mitogen-activated protein kinase kinase kinase 1
  • Synonyms
    lg, Mekk, MEKK1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346872
    NCBI Gene: 26401
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:111882962-111945527 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 63.36 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2323 from dbSNP Build 142
  • Strain Annotations
    17
  • PCR
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346872
 protein coding gene Chr13:111882962-111954803 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020934
 protein coding gene Chr13:114244794-114315565 (-)
A/J MGP_AJ_G0020884
 protein coding gene Chr13:109703324-109771378 (-)
AKR/J MGP_AKRJ_G0020859
 protein coding gene Chr13:113011967-113076383 (-)
BALB/cJ MGP_BALBcJ_G0020884
 protein coding gene Chr13:110398799-110463445 (-)
C3H/HeJ MGP_C3HHeJ_G0020673
 protein coding gene Chr13:112803266-112866672 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021320
 protein coding gene Chr13:117672766-117740756 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018889
 protein coding gene Chr13:105016429-105079893 (-)
CAST/EiJ MGP_CASTEiJ_G0020193
 protein coding gene Chr13:112409373-112483229 (-)
CBA/J MGP_CBAJ_G0020635
 protein coding gene Chr13:122187458-122253488 (-)
DBA/2J MGP_DBA2J_G0020758
 protein coding gene Chr13:109420616-109484136 (-)
FVB/NJ MGP_FVBNJ_G0020742
 protein coding gene Chr13:108113313-108173204 (-)
LP/J MGP_LPJ_G0020833
 protein coding gene Chr13:114297460-114372654 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020770
 protein coding gene Chr13:122513614-122582054 (-)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0019946
 protein coding gene Chr13:108157374-108223120 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019768
 protein coding gene Chr13:108766184-108837958 (-)
WSB/EiJ MGP_WSBEiJ_G0020250
 protein coding gene Chr13:113059673-113126537 (-)



Homology
more
  • Human Ortholog
    MAP3K1, mitogen-activated protein kinase kinase kinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP3K1, mitogen-activated protein kinase kinase kinase 1
  • Synonyms
    MAPKKK1, MEKK, MEKK 1, MEKK1, SRXY6
  • Links
    NCBI Gene ID: 4214
    neXtProt AC: NX_Q13233
    UniProt: Q13233

  • Chr Location
    5q11.2; chr5:56815549-56896152 (+)  GRCh38
Human Diseases
more
  • Diseases
    7 with human MAP3K1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    54 phenotypes from 5 alleles in 7 genetic backgrounds
    4 phenotypes from multigenic genotypes
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous allele are born with one or both eyes open, defects in eye morphology, and defects in ear morphology and function. Mice homozygous for a knock-out allele are born with open eyes and exhibit increased response to aortic banding and blood vessel healing. Mice homozygous for an ENU-induced mutation are severely deaf.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    49
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    950
  • Tissues
    78
  • cDNA Data
    6
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021754 Ensembl Gene Model | MGI Sequence Detail 62566 C57BL/6J ±  kb
    transcript ENSMUST00000109267 Ensembl | MGI Sequence Detail 6978 Not Applicable  
    polypeptide ENSMUSP00000104890 Ensembl | MGI Sequence Detail 1493 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 1
      cDNA 6
      Primer pair 6

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-28141, MGI:104845
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 14
      Gene Ontology 20
      Phenotypes 56
    • Earliest
      J:5056 Ricardo NS, et al., Further observations on lg MI (lid-gap Miller) and other ope1-eye mutants in the house mouse. Can J Genet Cytol. 1967 Sep;9(3):596-605
    • Latest
      J:347411 Kimura E, et al., MAP3K1 regulates female reproductive tract development. Dis Model Mech. 2024 Mar 1;17(3)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory