Map3k2 MGI Mouse Gene Detail - MGI:1346873 - mitogen-activated protein kinase kinase kinase 2

Symbol

Map3k2
Name

mitogen-activated protein kinase kinase kinase 2
Synonyms

9630061B06Rik, Mekk2, MEK kinase 2

Feature Type

protein coding gene
IDs

MGI:1346873
NCBI Gene: 26405
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr18:32296142-32369804 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 17.95 cM, cytoband B3
Mapping Data

3 experiments

SNPs within 2kb

1506 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346873	protein coding gene	Chr18:32296142-32369804 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024225	protein coding gene	Chr18:30291369-30368964 (+)
A/J	MGP_AJ_G0024191	protein coding gene	Chr18:29283533-29358275 (+)
AKR/J	MGP_AKRJ_G0024160	protein coding gene	Chr18:30100530-30177310 (+)
BALB/cJ	MGP_BALBcJ_G0024191	protein coding gene	Chr18:29379436-29455924 (+)
C3H/HeJ	MGP_C3HHeJ_G0023959	protein coding gene	Chr18:30140398-30218569 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024633	protein coding gene	Chr18:31374605-31453781 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022074	protein coding gene	Chr18:29519738-29590921 (+)
CAST/EiJ	MGP_CASTEiJ_G0023434	protein coding gene	Chr18:30030478-30109284 (+)
CBA/J	MGP_CBAJ_G0023927	protein coding gene	Chr18:32333980-32418650 (+)
DBA/2J	MGP_DBA2J_G0024059	protein coding gene	Chr18:28956882-29030738 (+)
FVB/NJ	MGP_FVBNJ_G0024025	protein coding gene	Chr18:28664819-28738493 (+)
LP/J	MGP_LPJ_G0024140	protein coding gene	Chr18:30376837-30455581 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024053	protein coding gene	Chr18:33671333-33759418 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024681	protein coding gene	Chr18:29960960-30035922 (+)
PWK/PhJ	MGP_PWKPhJ_G0023177	protein coding gene	Chr18:29124272-29200231 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022986	protein coding gene	Chr18:30202487-30279189 (+)
WSB/EiJ	MGP_WSBEiJ_G0023497	protein coding gene	Chr18:29866409-29943301 (+)

Human Ortholog

MAP3K2, mitogen-activated protein kinase kinase kinase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAP3K2, mitogen-activated protein kinase kinase kinase 2
Synonyms

MEKK2, MEKK2B
Links

HGNC:6854

NCBI Gene ID: 10746

neXtProt AC: NX_Q9Y2U5

UniProt: Q9Y2U5
Chr Location

2q14.3; chr2:127298668-127388465 (-) GRCh38

MGI Vertebrate Homology

Map3k2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MAP3K2
Gene Tree

Map3k2

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Endonuclease-mediated

3
Gene trapped

14
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene are grossly normal and fertile.

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All GO Annotations

16
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

896
Tissues

174
cDNA Data

59
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase map3k2

ZFIN map3k2

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All Sequences

44
RefSeq

4
UniProt

2
CCDS

CCDS29117.1

Ensembl

ENSMUSG00000024383 (Evidence)
NCBI Gene

26405

			Length	Strain/Species	Flank
genomic	26405	NCBI Gene Model \| MGI Sequence Detail	73663	C57BL/6J	± kb
transcript	NM_011946	RefSeq \| MGI Sequence Detail	10791	Not Specified
polypeptide	Q61083	UniProt \| EBI \| MGI Sequence Detail	619	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010135 mitogen-activated protein kinase kinase kinase 2

(term hierarchy)
EC

2.7.11.25
InterPro Domains

IPR050538 Mitogen-activated protein kinase kinase kinase

IPR034879 Mitogen-activated protein kinase kinase kinase 2/3, PB1 domain

IPR000270 PB1 domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

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All nucleic 61

cDNA 59

Primer pair 2

Microarray probesets 5

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MGD-MRK-39593, MGI:109594, MGI:2147242, MGI:2443659

Summaries

All 70

Developmental Gene Expression 4

Gene Ontology 10

Phenotypes 20
Earliest

J:31860 Blank JL, et al., Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase. J Biol Chem. 1996 Mar 8;271(10):5361-8
Latest

J:316856 Wu N, et al., MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche. Nature. 2021 Apr;592(7855):606-610

TSS for Map3k2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150385	Chr18:32296025-32296035 (+)	-112 bp
Tssr5269	Chr18:32296044-32296045 (+)	-97 bp
Tssr150386	Chr18:32296068-32296073 (+)	-71 bp
Tssr150387	Chr18:32296095-32296106 (+)	-41 bp
Tssr150388	Chr18:32296115-32296122 (+)	-23 bp
Tssr150389	Chr18:32296126-32296168 (+)	5 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24