Map3k3 MGI Mouse Gene Detail - MGI:1346874 - mitogen-activated protein kinase kinase kinase 3

Symbol

Map3k3
Name

mitogen-activated protein kinase kinase kinase 3
Synonyms

MAPKKK3, Mekk3

Feature Type

protein coding gene
IDs

MGI:1346874
NCBI Gene: 26406
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:105975439-106046272 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 68.89 cM
Mapping Data

1 experiment

SNPs within 2kb

1439 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346874	protein coding gene	Chr11:105975358-106047482 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019293	protein coding gene	Chr11:109362561-109434471 (+)
A/J	MGP_AJ_G0019261	protein coding gene	Chr11:104706513-104779915 (+)
AKR/J	MGP_AKRJ_G0019230	protein coding gene	Chr11:107832976-107906883 (+)
BALB/cJ	MGP_BALBcJ_G0019235	protein coding gene	Chr11:105108953-105182391 (+)
C3H/HeJ	MGP_C3HHeJ_G0019044	protein coding gene	Chr11:108121054-108193391 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019685	protein coding gene	Chr11:112713638-112788100 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017310	protein coding gene	Chr11:101989077-102057798 (+)
CAST/EiJ	MGP_CASTEiJ_G0018597	protein coding gene	Chr11:109179965-109251791 (+)
CBA/J	MGP_CBAJ_G0019013	protein coding gene	Chr11:117403374-117482657 (+)
DBA/2J	MGP_DBA2J_G0019125	protein coding gene	Chr11:104177564-104249777 (+)
FVB/NJ	MGP_FVBNJ_G0019116	protein coding gene	Chr11:103679435-103750683 (+)
LP/J	MGP_LPJ_G0019195	protein coding gene	Chr11:109807034-109882635 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019146	protein coding gene	Chr11:116693483-116771518 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019722	protein coding gene	Chr11:108310127-108394853 (+)
PWK/PhJ	MGP_PWKPhJ_G0018362	protein coding gene	Chr11:105270905-105343602 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018153	protein coding gene	Chr11:108085973-108158477 (+)
WSB/EiJ	MGP_WSBEiJ_G0018648	protein coding gene	Chr11:108285881-108358556 (+)

Human Ortholog

MAP3K3, mitogen-activated protein kinase kinase kinase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAP3K3, mitogen-activated protein kinase kinase kinase 3
Synonyms

MAPKKK3, MEKK3
Links

HGNC:6855

NCBI Gene ID: 4215

neXtProt AC: NX_Q99759

UniProt: Q99759
Chr Location

17q23.3; chr17:63622415-63696305 (+) GRCh38

MGI Vertebrate Homology

Map3k3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MAP3K3
Gene Tree

Map3k3

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Phenotype Summary

25 phenotypes from 5 alleles in 4 genetic backgrounds
2 phenotypes from multigenic genotypes
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

4
Gene trapped

1
Targeted

8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene die as embryos before E11.5. vascular remodeling does not take place normally.

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All GO Annotations

18
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

749
Tissues

30
cDNA Data

153
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase map3k22, map3k3

ZFIN map3k3

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All Sequences

46
RefSeq

9
UniProt

3
CCDS

CCDS25548.1

Ensembl

ENSMUSG00000020700 (Evidence)
NCBI Gene

26406

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020700	Ensembl Gene Model \| MGI Sequence Detail	70834	C57BL/6J	± kb
transcript	ENSMUST00000002044	Ensembl \| MGI Sequence Detail	3450	Not Applicable
polypeptide	ENSMUSP00000002044	Ensembl \| MGI Sequence Detail	626	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010136 mitogen-activated protein kinase kinase kinase 3

(term hierarchy)
EC

2.7.11.25
InterPro Domains

IPR050538 Mitogen-activated protein kinase kinase kinase

IPR034879 Mitogen-activated protein kinase kinase kinase 2/3, PB1 domain

IPR000270 PB1 domain

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

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All nucleic 156

cDNA 153

Primer pair 3

Microarray probesets 5

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MGD-MRK-39592, MGI:109593, MGI:2144565

Summaries

All 63

Developmental Gene Expression 7

Gene Ontology 13

Phenotypes 20
Earliest

J:31860 Blank JL, et al., Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase. J Biol Chem. 1996 Mar 8;271(10):5361-8
Latest

J:339061 Tsitsikov EN, et al., TRAF7 is an essential regulator of blood vessel integrity during mouse embryonic and neonatal development. iScience. 2023 Aug 18;26(8):107474

TSS for Map3k3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105485	Chr11:105975371-105975385 (+)	-61 bp
Tssr105486	Chr11:105975403-105975449 (+)	-13 bp
Tssr105487	Chr11:105976189-105976192 (+)	752 bp
Tssr105488	Chr11:105981799-105981832 (+)	6,377 bp
Tssr105489	Chr11:105987824-105987830 (+)	12,388 bp
Tssr105490	Chr11:106004563-106004569 (+)	29,127 bp
Tssr105491	Chr11:106033261-106033278 (+)	57,831 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24