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Map3k8 Gene Detail
Summary
  • Symbol
    Map3k8
  • Name
    mitogen-activated protein kinase kinase kinase 8
  • Synonyms
    c-COT, Cot, Cot/Tpl2, Tpl-2, Tpl2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346878
    NCBI Gene: 26410
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:4331325-4352978 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 2.73 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    599 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346878
 protein coding gene Chr18:4331325-4353015 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024122
 protein coding gene Chr18:1176659-1198306 (-)
A/J MGP_AJ_G0024084
 protein coding gene Chr18:1214944-1236701 (-)
AKR/J MGP_AKRJ_G0024052
 protein coding gene Chr18:1198209-1219857 (-)
BALB/cJ MGP_BALBcJ_G0024084
 protein coding gene Chr18:1200294-1221944 (-)
C3H/HeJ MGP_C3HHeJ_G0023849
 protein coding gene Chr18:1172470-1194129 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024529
 protein coding gene Chr18:1308127-1329775 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021968
 protein coding gene Chr18:1034196-1056095 (-)
CAST/EiJ MGP_CASTEiJ_G0023328
 protein coding gene Chr18:1130498-1153701 (-)
CBA/J MGP_CBAJ_G0023823
 protein coding gene Chr18:1267809-1290912 (-)
DBA/2J MGP_DBA2J_G0023951
 protein coding gene Chr18:1144761-1166389 (-)
FVB/NJ MGP_FVBNJ_G0023917
 protein coding gene Chr18:1131508-1153113 (-)
LP/J MGP_LPJ_G0024035
 protein coding gene Chr18:1261604-1283296 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023945
 protein coding gene Chr18:1289691-1311353 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024574
 protein coding gene Chr18:1147928-1169599 (-)
PWK/PhJ MGP_PWKPhJ_G0023073
 protein coding gene Chr18:1146072-1167936 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022884
 protein coding gene Chr18:1413743-1435499 (-)
WSB/EiJ MGP_WSBEiJ_G0023394
 protein coding gene Chr18:1175593-1197228 (-)



Homology
more
  • Human Ortholog
    MAP3K8, mitogen-activated protein kinase kinase kinase 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP3K8, mitogen-activated protein kinase kinase kinase 8
  • Synonyms
    AURA2, c-COT, COT, EST, ESTF, MEKK8, Tpl-2, TPL2
  • Links
    NCBI Gene ID: 1326
    neXtProt AC: NX_P41279
    UniProt: P41279

  • Chr Location
    10p11.23; chr10:30434021-30461833 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human MAP3K8 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 10 alleles in 13 genetic backgrounds
    6 phenotypes from multigenic genotypes
    89 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant mice resist endotoxic shock. Their MHC II expression is enhanced. Macrophages' TNF-alpha response to viruses and to all TLR ligands is impaired. Macrophage and T-cell secretion of other cytokines in response to various TLR ligands or OVA is aberrant. Anti-OVA Ig classes are abnormally skewed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    780
  • Tissues
    44
  • cDNA Data
    24
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26410 NCBI Gene Model | MGI Sequence Detail 21654 C57BL/6J ±  kb
    transcript NM_007746 RefSeq | MGI Sequence Detail 2507 ZRU/MplStud  
    polypeptide Q07174 UniProt | EBI | MGI Sequence Detail 467 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 6
      cDNA 25

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15201, MGD-MRK-2095, MGI:88472, MGI:98808
    References
    more
    • Summaries
      All 151
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 89
    • Earliest
      J:1701 Justice MJ, et al., A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18. Genomics. 1992 Aug;13(4):1281-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory