Avpr1b MGI Mouse Gene Detail - MGI:1347010 - arginine vasopressin receptor 1B

Symbol

Avpr1b
Name

arginine vasopressin receptor 1B
Synonyms

AVPR3, V1bR, V1BR, V3/V1b, V3/V1b pituitary vasopressin receptor, VPR3

Feature Type

protein coding gene
IDs

MGI:1347010
NCBI Gene: 26361
Alliance

gene page

Sequence Map

Chr1:131526977-131539738 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 57.09 cM, cytoband E4
Mapping Data

3 experiments

SNPs within 2kb

492 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347010	protein coding gene	Chr1:131526908-131539740 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016455	protein coding gene	Chr1:135037794-135053750 (+)
A/J	MGP_AJ_G0016438	protein coding gene	Chr1:130041587-130054978 (+)
AKR/J	MGP_AKRJ_G0016403	protein coding gene	Chr1:133857259-133870161 (+)
BALB/cJ	MGP_BALBcJ_G0016398	protein coding gene	Chr1:130369385-130383309 (+)
C3H/HeJ	MGP_C3HHeJ_G0016224	protein coding gene	Chr1:133999555-134014260 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016859	protein coding gene	Chr1:140055946-140069915 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014573	protein coding gene	Chr1:123182024-123193640 (+)
CAST/EiJ	MGP_CASTEiJ_G0015804	protein coding gene	Chr1:133000088-133012945 (+)
CBA/J	MGP_CBAJ_G0016196	protein coding gene	Chr1:144849354-144866210 (+)
DBA/2J	MGP_DBA2J_G0016303	protein coding gene	Chr1:129010765-129026500 (+)
FVB/NJ	MGP_FVBNJ_G0016302	protein coding gene	Chr1:127639475-127654069 (+)
LP/J	MGP_LPJ_G0016374	protein coding gene	Chr1:136345537-136358093 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016327	protein coding gene	Chr1:150614764-150628464 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016895	protein coding gene	Chr1:133621553-133635004 (+)
PWK/PhJ	MGP_PWKPhJ_G0015590	protein coding gene	Chr1:127969295-127982394 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015377	protein coding gene	Chr1:132569726-132583112 (+)
WSB/EiJ	MGP_WSBEiJ_G0015866	protein coding gene	Chr1:133608637-133622165 (+)

Human Ortholog

AVPR1B, arginine vasopressin receptor 1B

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AVPR1B, arginine vasopressin receptor 1B
Synonyms

AVPR3, V1bR, VPR3
Links

HGNC:896

NCBI Gene ID: 553

neXtProt AC: NX_P47901

UniProt: P47901
Chr Location

1q32.1; chr1:206106936-206117699 (-) GRCh38

MGI Vertebrate Homology

Avpr1b stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: AVPR1B
Gene Tree

Avpr1b

Diseases

3 with human AVPR1B associations

				Human Disease	Mouse Models
				autism spectrum disorder IDs autism spectrum disorder DOID:0060041 MESH:D000067877
				bipolar disorder IDs bipolar disorder DOID:3312 DOID:3311 DOID:9554 DOID:9555 ICD10CM:F31 ICD9CM:296.40 ICD9CM:296.60 ICD9CM:296.80 MESH:D001714 NCI:C34423 NCI:C34424 NCI:C34805 UMLS_CUI:C0005586 UMLS_CUI:C0005587 UMLS_CUI:C0024713 UMLS_CUI:C0236780
				mood disorder IDs mood disorder DOID:3324 EFO:0004247 ICD10CM:F39 MESH:D019964 NCI:C92200 UMLS_CUI:C0525045

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 3 alleles in 3 genetic backgrounds
46 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

2
Endonuclease-mediated

3
Radiation induced

1
Targeted

11
Transgenic

1
Genomic Mutations

3 involving Avpr1b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mice for one allele display dysregulation of the hypothalamic-pituitary-adrenal axis activity under stress and resting conditions. Homozygous null mice for other alleles display decreased aggression or an increased propensity for seizures.

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All GO Annotations

28
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

875
Tissues

83
cDNA Data

6
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

32
RefSeq

2
UniProt

2
CCDS

CCDS35703.1

Ensembl

ENSMUSG00000026432 (Evidence)
NCBI Gene

26361

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026432	Ensembl Gene Model \| MGI Sequence Detail	12762	C57BL/6J	± kb
transcript	ENSMUST00000027690	Ensembl \| MGI Sequence Detail	4023	Not Applicable
polypeptide	ENSMUSP00000027690	Ensembl \| MGI Sequence Detail	421	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001682 vasopressin V1b receptor

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR001817 Vasopressin receptor

IPR000628 Vasopressin V1B receptor

IPR015076 Vasopressin V1 receptor, C-terminal
GlyGen

Q9WU02 3 sites, 2 N-linked glycans (2 sites)

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All nucleic 8

cDNA 6

Primer pair 1

Other 1

Microarray probesets 2

Summaries

All 75

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 46
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:351137 Hayashi H, et al., The bilevel chamber revealed differential involvement of vasopressin and oxytocin receptors in female mouse sexual behavior. PLoS One. 2024;19(6):e0304703

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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