Hsf4 MGI Mouse Gene Detail - MGI:1347058 - heat shock transcription factor 4

Symbol

Hsf4
Name

heat shock transcription factor 4
Synonyms

ldis1

Feature Type

protein coding gene
IDs

MGI:1347058
NCBI Gene: 26386
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr8:105996433-106002477 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 53.04 cM, cytoband D1
Mapping Data

3 experiments

SNPs within 2kb

176 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347058	protein coding gene	Chr8:105996392-106002477 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034033	protein coding gene	Chr8:107535118-107541162 (+)
A/J	MGP_AJ_G0034014	protein coding gene	Chr8:103247760-103253804 (+)
AKR/J	MGP_AKRJ_G0033940	protein coding gene	Chr8:106231765-106237813 (+)
BALB/cJ	MGP_BALBcJ_G0034007	protein coding gene	Chr8:103422918-103428962 (+)
C3H/HeJ	MGP_C3HHeJ_G0033719	protein coding gene	Chr8:106977633-106983673 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034527	protein coding gene	Chr8:111484304-111490348 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031469	protein coding gene	Chr8:96396730-96403354 (+)
CAST/EiJ	MGP_CASTEiJ_G0033045	protein coding gene	Chr8:106476553-106482619 (+)
CBA/J	MGP_CBAJ_G0033692	protein coding gene	Chr8:115081688-115087738 (+)
DBA/2J	MGP_DBA2J_G0033847	protein coding gene	Chr8:102592339-102598383 (+)
FVB/NJ	MGP_FVBNJ_G0033793	protein coding gene	Chr8:101515975-101522024 (+)
LP/J	MGP_LPJ_G0033938	protein coding gene	Chr8:107746243-107752287 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033836	protein coding gene	Chr8:118294515-118300559 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034545	protein coding gene	Chr8:106205755-106211799 (+)
PWK/PhJ	MGP_PWKPhJ_G0032746	protein coding gene	Chr8:101977415-101983582 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032587	protein coding gene	Chr8:104881426-104888943 (+)
WSB/EiJ	MGP_WSBEiJ_G0033161	protein coding gene	Chr8:106858853-106864901 (+)

Human Ortholog

HSF4, heat shock transcription factor 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HSF4, heat shock transcription factor 4
Synonyms

CTM, CTRCT5
Links

HGNC:5227

NCBI Gene ID: 3299

neXtProt AC: NX_Q9ULV5

UniProt: Q9ULV5
Chr Location

16q22.1; chr16:67163761-67169945 (+) GRCh38

MGI Vertebrate Homology

Hsf4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HSF4
Gene Tree

Hsf4

Diseases

1 with Hsf4 mouse models; 2 with human HSF4 associations

Human Disease

Mouse Models

cataract 5 multiple types

IDs

View 2 models

cataract

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

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Phenotype Summary

15 phenotypes from 6 alleles in 7 genetic backgrounds
2 phenotypes from multigenic genotypes
3 images
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

2
Spontaneous

1
Targeted

6
Transgenic

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display abnormal lens morphology and cataracts.

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All GO Annotations

17
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

765
Tissues

49
cDNA Data

10
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN hsf4

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All Sequences

69
RefSeq

15
UniProt

8
CCDS

CCDS57638.1, CCDS57639.1, CCDS57640.1

Ensembl

ENSMUSG00000033249 (Evidence)
NCBI Gene

26386

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033249	Ensembl Gene Model \| MGI Sequence Detail	6045	C57BL/6J	± kb
transcript	ENSMUST00000036127	Ensembl \| MGI Sequence Detail	1739	Not Applicable
polypeptide	ENSMUSP00000048904	Ensembl \| MGI Sequence Detail	492	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000008793 heat shock factor protein 4

(term hierarchy)
InterPro Domains

IPR000232 Heat shock factor (HSF)-type, DNA-binding

IPR027725 Heat shock transcription factor family

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 11

cDNA 10

Primer pair 1

Microarray probesets 3

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MGI:3056558

Summaries

All 55

Developmental Gene Expression 13

Diseases 2

Gene Ontology 4

Phenotypes 23
Earliest

J:57773 Tanabe M, et al., The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing. J Biol Chem. 1999 Sep 24;274(39):27845-56
Latest

J:350084 Zhang L, et al., Integrative transcriptomic profiling of ncRNAs and mRNAs in developing mouse lens. Front Genet. 2024;15:1405715

TSS for Hsf4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79115	Chr8:105996420-105996468 (+)	11 bp
Tssr79116	Chr8:105996469-105996489 (+)	46 bp
Tssr79117	Chr8:105998703-105998720 (+)	2,279 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24