Bdp1 MGI Mouse Gene Detail - MGI:1347077 - B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB

Symbol

Bdp1
Name

B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
Synonyms

B130055N23Rik, G630013P12Rik, TAF3B1, TFC5, TFIIIB150, TFIIIB90, Tfnr

Feature Type

protein coding gene
IDs

MGI:1347077
NCBI Gene: 544971
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr13:100154502-100240578 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 52.92 cM
Mapping Data

6 experiments

SNPs within 2kb

1452 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347077	protein coding gene	Chr13:100154502-100244524 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020879	protein coding gene	Chr13:101843039-101932096 (-)
A/J	MGP_AJ_G0020833	protein coding gene	Chr13:97916029-98013607 (-)
AKR/J	MGP_AKRJ_G0020807	protein coding gene	Chr13:100917343-101006671 (-)
BALB/cJ	MGP_BALBcJ_G0020831	protein coding gene	Chr13:98632830-98719306 (-)
C3H/HeJ	MGP_C3HHeJ_G0020622	protein coding gene	Chr13:100640129-100728065 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021265	protein coding gene	Chr13:104868192-104966769 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018834	protein coding gene	Chr13:93639157-93726927 (-)
CAST/EiJ	MGP_CASTEiJ_G0020140	protein coding gene	Chr13:100081628-100170895 (-)
CBA/J	MGP_CBAJ_G0020582	protein coding gene	Chr13:109044673-109139388 (-)
DBA/2J	MGP_DBA2J_G0020707	protein coding gene	Chr13:97690400-97776457 (-)
FVB/NJ	MGP_FVBNJ_G0020688	protein coding gene	Chr13:96435165-96521834 (-)
LP/J	MGP_LPJ_G0020782	protein coding gene	Chr13:101932748-102019337 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020716	protein coding gene	Chr13:109291915-109386408 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021306	protein coding gene	Chr13:100376985-100466707 (-)
PWK/PhJ	MGP_PWKPhJ_G0019893	protein coding gene	Chr13:96519909-96607683 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019716	protein coding gene	Chr13:96660524-96747777 (-)
WSB/EiJ	MGP_WSBEiJ_G0020198	protein coding gene	Chr13:100805201-100892889 (-)

Human Ortholog

BDP1, BDP1 general transcription factor IIIB subunit

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BDP1, BDP1 general transcription factor IIIB subunit
Synonyms

DFNB112, HSA238520, TAF3B1, TFC5, TFIIIB'', TFIIIB150, TFIIIB90, TFNR
Links

HGNC:13652

NCBI Gene ID: 55814

neXtProt AC: NX_A6H8Y1

UniProt: A6H8Y1
Chr Location

5q13.2; chr5:71455651-71578288 (+) GRCh38

MGI Vertebrate Homology

Bdp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BDP1
Gene Tree

Bdp1

Diseases

1 with human BDP1 associations

				Human Disease	Mouse Models
				autosomal recessive nonsyndromic deafness 112 IDs autosomal recessive nonsyndromic deafness 112 DOID:0111637 OMIM:618257

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

4
Gene trapped

3
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

89 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

863
Tissues

102
cDNA Data

9
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bdp1

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All Sequences

68
RefSeq

17
UniProt

4
CCDS

CCDS49343.1

Ensembl

ENSMUSG00000049658 (Evidence)
NCBI Gene

544971

			Length	Strain/Species	Flank
genomic	ENSMUSG00000049658	Ensembl Gene Model \| MGI Sequence Detail	86077	C57BL/6J	± kb
transcript	ENSMUST00000109379	Ensembl \| MGI Sequence Detail	7567	Not Applicable
polypeptide	ENSMUSP00000105005	Ensembl \| MGI Sequence Detail	2471	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004717 transcription factor TFIIIB component B''

(term hierarchy)
InterPro Domains

IPR009057 Homeobox-like domain superfamily

IPR001005 SANT/Myb domain

IPR039467 Transcription factor TFIIIB component B'', Myb domain

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All nucleic 24

Genomic 14

cDNA 9

Primer pair 1

Microarray probesets 5

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MGI:2145280, MGI:2145407, MGI:2145429, MGI:2443979

Summaries

All 40

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 9
Earliest

J:57778 Endrizzi M, et al., Comparative sequence analysis of the mouse and human Lgn1/SMA interval. Genomics. 1999 Sep 1;60(2):137-51
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Bdp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr123773	Chr13:100240591-100240602 (-)	-19 bp
Tssr123772	Chr13:100240572-100240590 (-)	-3 bp
Tssr123771	Chr13:100240535-100240561 (-)	30 bp
Tssr123770	Chr13:100215195-100215230 (-)	25,365 bp
Tssr123769	Chr13:100204424-100204432 (-)	36,150 bp
Tssr123768	Chr13:100202518-100202541 (-)	38,048 bp
Tssr123767	Chr13:100168682-100168693 (-)	71,890 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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