Cetn1 MGI Mouse Gene Detail - MGI:1347086

Symbol

Cetn1
Name

centrin 1

Feature Type

protein coding gene
IDs

MGI:1347086
NCBI Gene: 26369
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr18:9618419-9619469 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 4.91 cM, cytoband A2
Mapping Data

3 experiments

SNPs within 2kb

114 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347086	protein coding gene	Chr18:9615524-9619478 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024141	protein coding gene	Chr18:6541356-6545199 (-)
A/J	MGP_AJ_G0024103	protein coding gene	Chr18:6499733-6504782 (-)
AKR/J	MGP_AKRJ_G0024070	protein coding gene	Chr18:6657765-6663486 (-)
BALB/cJ	MGP_BALBcJ_G0024102	protein coding gene	Chr18:6477539-6481715 (-)
C3H/HeJ	MGP_C3HHeJ_G0023869	protein coding gene	Chr18:6545764-6551022 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024547	protein coding gene	Chr18:6930027-6936781 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021986	protein coding gene	Chr18:6053790-6057652 (-)
CAST/EiJ	MGP_CASTEiJ_G0023346	protein coding gene	Chr18:6516678-6520544 (-)
CBA/J	MGP_CBAJ_G0023841	protein coding gene	Chr18:6922857-6926726 (-)
DBA/2J	MGP_DBA2J_G0023970	protein coding gene	Chr18:6353001-6357379 (-)
FVB/NJ	MGP_FVBNJ_G0023935	protein coding gene	Chr18:6319832-6324774 (-)
LP/J	MGP_LPJ_G0024053	protein coding gene	Chr18:6617076-6620946 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023964	protein coding gene	Chr18:7124313-7129380 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024593	protein coding gene	Chr18:6497946-6502978 (-)
PWK/PhJ	MGP_PWKPhJ_G0023091	protein coding gene	Chr18:6385419-6389638 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022902	protein coding gene	Chr18:6802739-6806582 (-)
WSB/EiJ	MGP_WSBEiJ_G0023412	protein coding gene	Chr18:6481062-6485048 (-)

Human Ortholog

CETN1, centrin 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CETN1, centrin 1
Synonyms

CEN1, CETN
Links

HGNC:1866

NCBI Gene ID: 1068

neXtProt AC: NX_Q12798

UniProt: Q12798
Chr Location

18p11.32; chr18:580380-582114 (+) GRCh38

MGI Vertebrate Homology

Cetn1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CETN1
Gene Tree

Cetn1

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Phenotype Summary

19 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

2
Targeted

2
Find Mice (IMSR)

2 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show male infertility associated with oligozoospermia, teratozoospermia, immotile sperm, and altered centriole rearrangement at a late stage of spermiogenesis.

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All GO Annotations

19
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

4
cDNA Data

96
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cetn2

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All Sequences

43
RefSeq

2
UniProt

1
CCDS

CCDS37731.1

Ensembl

ENSMUSG00000050996 (Evidence)
NCBI Gene

26369

			Length	Strain/Species	Flank
genomic	26369	NCBI Gene Model \| MGI Sequence Detail	1051	C57BL/6J	± kb
transcript	NM_007593	RefSeq \| MGI Sequence Detail	1051	C57BL/6
polypeptide	P41209	UniProt \| EBI \| MGI Sequence Detail	172	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005370 centrin-1

(term hierarchy)
PDB

5D43
InterPro Domains

IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site

IPR050145 Calmodulin and Centrin Calcium-Binding Families

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

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All nucleic 98

Genomic 2

cDNA 96

Microarray probesets 6

Summaries

All 41

Developmental Gene Expression 4

Gene Ontology 13

Phenotypes 2
Earliest

J:15453 Ogawa K, et al., cDNA sequence for mouse caltractin. Biochim Biophys Acta. 1993 Oct 19;1216(1):126-8
Latest

J:345633 Langner E, et al., Cep120 is essential for kidney stromal progenitor cell growth and differentiation. EMBO Rep. 2024 Jan;25(1):428-454

TSS for Cetn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr152401	Chr18:9619460-9619482 (-)	-2 bp
Tssr152400	Chr18:9619436-9619452 (-)	25 bp
Tssr152399	Chr18:9619423-9619434 (-)	40 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24