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Adgre5 Gene Detail
Summary
  • Symbol
    Adgre5
  • Name
    adhesion G protein-coupled receptor E5
  • Synonyms
    Cd97, EGF-TM7 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347095
    NCBI Gene: 26364
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:84449874-84467812 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 40.22 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    425 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347095
 protein coding gene Chr8:84449874-84467955 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033840
 protein coding gene Chr8:84567954-84587253 (-)
A/J MGP_AJ_G0033823
 protein coding gene Chr8:81262015-81281029 (-)
AKR/J MGP_AKRJ_G0033749
 protein coding gene Chr8:83658941-83677063 (-)
BALB/cJ MGP_BALBcJ_G0033816
 protein coding gene Chr8:81362855-81380964 (-)
C3H/HeJ MGP_C3HHeJ_G0033526
 protein coding gene Chr8:84277309-84295402 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034336
 protein coding gene Chr8:87787049-87805124 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031278
 protein coding gene Chr8:75047609-75066533 (-)
CAST/EiJ MGP_CASTEiJ_G0032856
 protein coding gene Chr8:83686390-83704517 (-)
CBA/J MGP_CBAJ_G0033504
 protein coding gene Chr8:90944287-90962380 (-)
DBA/2J MGP_DBA2J_G0033657
 protein coding gene Chr8:80901849-80919942 (-)
FVB/NJ MGP_FVBNJ_G0033603
 protein coding gene Chr8:79814954-79833819 (-)
LP/J MGP_LPJ_G0033747
 protein coding gene Chr8:84669675-84687797 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033645
 protein coding gene Chr8:93434467-93454158 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034353
 protein coding gene Chr8:83630068-83649539 (-)
PWK/PhJ MGP_PWKPhJ_G0032560
 protein coding gene Chr8:80115750-80134113 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032397
 protein coding gene Chr8:82430856-82452352 (-)
WSB/EiJ MGP_WSBEiJ_G0032969
 protein coding gene Chr8:84038074-84057481 (-)



Homology
more
  • Human Ortholog
    ADGRE2, adhesion G protein-coupled receptor E2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADGRE2, adhesion G protein-coupled receptor E2
  • Synonyms
    CD312, CD97, EMR2, VBU
  • Links
    NCBI Gene ID: 30817
    neXtProt AC: NX_Q9UHX3
    UniProt: Q9UHX3

  • Chr Location
    19p13.12; chr19:14724171-14778560 (-)  GRCh38
  • Human Ortholog
    ADGRE5, adhesion G protein-coupled receptor E5
  • Synonyms
    CD97, TM7LN1
  • Links
    NCBI Gene ID: 976
    neXtProt AC: NX_P48960
    UniProt: P48960

  • Chr Location
    19p13.12; chr19:14380501-14408725 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ADGRE2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a normal phenotype apart from mild granulocytosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    966
  • Tissues
    120
  • cDNA Data
    94
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 26364 NCBI Gene Model | MGI Sequence Detail 17939 C57BL/6J ±  kb
transcript NM_011925 RefSeq | MGI Sequence Detail 3131 ZRU/MplStud  
polypeptide Q9Z0M6 UniProt | EBI | MGI Sequence Detail 818 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 96
    cDNA 95
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142420
References
more
  • Summaries
    All 88
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 54
  • Earliest
    J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
  • Latest
    J:346729 Liu D, et al., Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function. Nat Immunol. 2024 Jan;25(1):142-154
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory