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Axl Gene Detail
Summary
  • Symbol
    Axl
  • Name
    AXL receptor tyrosine kinase
  • Synonyms
    Ark, Tyro7, Ufo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347244
    NCBI Gene: 26362
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:25456698-25488130 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 14.02 cM, cytoband A3-B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    872 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347244
 protein coding gene Chr7:25455925-25488502 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031879
 protein coding gene Chr7:24268749-24302400 (-)
A/J MGP_AJ_G0031858
 protein coding gene Chr7:23632680-23666366 (-)
AKR/J MGP_AKRJ_G0031787
 protein coding gene Chr7:24245617-24279736 (-)
BALB/cJ MGP_BALBcJ_G0031863
 protein coding gene Chr7:23872367-23903400 (-)
C3H/HeJ MGP_C3HHeJ_G0031584
 protein coding gene Chr7:24649124-24688759 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032327
 protein coding gene Chr7:25086863-25117712 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029382
 protein coding gene Chr7:24972866-25004082 (-)
CAST/EiJ MGP_CASTEiJ_G0030924
 protein coding gene Chr7:18064204-18095040 (-)
CBA/J MGP_CBAJ_G0031549
 protein coding gene Chr7:25973943-26010042 (-)
DBA/2J MGP_DBA2J_G0031703
 protein coding gene Chr7:23526164-23559027 (-)
FVB/NJ MGP_FVBNJ_G0031656
 protein coding gene Chr7:23558490-23590543 (-)
LP/J MGP_LPJ_G0031782
 protein coding gene Chr7:24544599-24578563 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031693
 protein coding gene Chr7:25691967-25724112 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032359
 protein coding gene Chr7:23878557-23915328 (-)
PWK/PhJ MGP_PWKPhJ_G0030648
 protein coding gene Chr7:18479823-18519498 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030478
 protein coding gene Chr7:15206991-15239324 (-)
WSB/EiJ MGP_WSBEiJ_G0031027
 protein coding gene Chr7:24102537-24134698 (-)



Homology
more
  • Human Ortholog
    AXL, AXL receptor tyrosine kinase
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AXL, AXL receptor tyrosine kinase
  • Synonyms
    ARK, AXL3, JTK11, Tyro7, UFO
  • Links
    NCBI Gene ID: 558
    neXtProt AC: NX_P30530
    UniProt: P30530

  • Chr Location
    19q13.2; chr19:41219223-41261766 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human AXL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    52 phenotypes from multigenic genotypes
    87 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are phenotypically normal, however in conjunction with mutations in other related receptor tyrosine kinases, mutations of this gene results in fertility defects, autoimmunity abnormalities, and aberrant apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    141
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1175
  • Tissues
    197
  • cDNA Data
    136
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002602 Ensembl Gene Model | MGI Sequence Detail 31433 C57BL/6J ±  kb
    transcript ENSMUST00000002677 Ensembl | MGI Sequence Detail 4265 Not Applicable  
    polypeptide ENSMUSP00000002677 Ensembl | MGI Sequence Detail 888 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 139
      cDNA 136
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15343, MGI:2141908, MGI:98896
    References
    more
    • Summaries
      All 155
      Developmental Gene Expression 18
      Diseases 1
      Gene Ontology 26
      Phenotypes 87
    • Earliest
      J:18115 Janssen JW, et al., A novel putative tyrosine kinase receptor with oncogenic potential. Oncogene. 1991 Nov;6(11):2113-20
    • Latest
      J:346862 Cheng M, et al., CD276-dependent efferocytosis by tumor-associated macrophages promotes immune evasion in bladder cancer. Nat Commun. 2024 Apr 1;15(1):2818
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory