Ceacam10 MGI Mouse Gene Detail - MGI:1347248 - CEA cell adhesion molecule 10

Symbol

Ceacam10
Name

CEA cell adhesion molecule 10
Synonyms

Bgp3, Cea10

Feature Type

protein coding gene
IDs

MGI:1347248
NCBI Gene: 26366
Member of

Cea cluster
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr7:24476631-24484082 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 12.78 cM
Mapping Data

3 experiments

SNPs within 2kb

353 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1347248	protein coding gene	Chr7:24476592-24484082 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031843	protein coding gene	Chr7:23159673-23174036 (+)
A/J	MGP_AJ_G0031822	protein coding gene	Chr7:22607604-22615228 (+)
AKR/J	MGP_AKRJ_G0031751	protein coding gene	Chr7:23115980-23128815 (+)
BALB/cJ	MGP_BALBcJ_G0031828	protein coding gene	Chr7:22812688-22822718 (+)
C3H/HeJ	MGP_C3HHeJ_G0031548	protein coding gene	Chr7:23525990-23536450 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032291	protein coding gene	Chr7:23941545-23954966 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029346	protein coding gene	Chr7:24052110-24059302 (+)
CAST/EiJ	MGP_CASTEiJ_G0030888	protein coding gene	Chr7:17031153-17039184 (+)
CBA/J	MGP_CBAJ_G0031513	protein coding gene	Chr7:24820186-24825693 (+)
DBA/2J	MGP_DBA2J_G0031667	protein coding gene	Chr7:22518322-22526073 (+)
FVB/NJ	MGP_FVBNJ_G0031620	protein coding gene	Chr7:22487345-22497354 (+)
LP/J	MGP_LPJ_G0031746	protein coding gene	Chr7:23499294-23505692 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031657	protein coding gene	Chr7:24557640-24572064 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032323	protein coding gene	Chr7:22844185-22851579 (+)
PWK/PhJ	MGP_PWKPhJ_G0030612	protein coding gene	Chr7:17433040-17450448 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030443	protein coding gene	Chr7:14142203-14149376 (+)
WSB/EiJ	MGP_WSBEiJ_G0030992	protein coding gene	Chr7:22992599-23006661 (+)

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MGI Vertebrate Homology

Ceacam10 stringent orthology
1 mouse;18 zebrafish
Gene Tree

Ceacam10

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

20 strains or lines available

Animals homozygous for a mutation in this gene are fertile and viable. However, a small but significant 23% reduction in litter size was observed in homozygous matings.

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All GO Annotations

8
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

827
Tissues

49
cDNA Data

28
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

44
RefSeq

6
UniProt

4
CCDS

CCDS39833.1, CCDS90181.1

Ensembl

ENSMUSG00000054169 (Evidence)
NCBI Gene

26366

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054169	Ensembl Gene Model \| MGI Sequence Detail	7452	C57BL/6J	± kb
transcript	ENSMUST00000038069	Ensembl \| MGI Sequence Detail	1048	Not Applicable
polypeptide	ENSMUSP00000037036	Ensembl \| MGI Sequence Detail	265	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006177 carcinoembryonic antigen-related cell adhesion molecule 10

(term hierarchy)
InterPro Domains

IPR050831 Carcinoembryonic antigen-related cell adhesion

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR013106 Immunoglobulin V-set domain
GlyGen

Q61400 4 sites, 2 N-linked glycans (2 sites)

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All nucleic 38

Genomic 5

cDNA 31

Primer pair 2

Microarray probesets 6

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MGD-MRK-24099, MGI:103228

Summaries

All 34

Developmental Gene Expression 7

Gene Ontology 3

Phenotypes 7
Earliest

J:25589 Keck U, et al., The cea10 gene encodes a secreted member of the murine carcinoembryonic antigen family and is expressed in the placenta, gastrointestinal tract and bone marrow. Eur J Biochem. 1995 Apr 15;229(2):455-64
Latest

J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584

TSS for Ceacam10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65027	Chr7:24476597-24476672 (+)	4 bp
Tssr65028	Chr7:24477559-24477563 (+)	930 bp
Tssr65029	Chr7:24477569-24477577 (+)	942 bp
Tssr65030	Chr7:24477593-24477611 (+)	971 bp
Tssr65031	Chr7:24477642-24477643 (+)	1,012 bp
Tssr65032	Chr7:24477758-24477766 (+)	1,131 bp
Tssr65033	Chr7:24477836-24477846 (+)	1,210 bp
Tssr65034	Chr7:24480116-24480151 (+)	3,503 bp
Tssr65035	Chr7:24480290-24480296 (+)	3,662 bp
Tssr65036	Chr7:24480306-24480323 (+)	3,684 bp
Tssr65037	Chr7:24480370-24480379 (+)	3,744 bp
Tssr65038	Chr7:24483912-24483914 (+)	7,282 bp
Tssr65039	Chr7:24484006-24484009 (+)	7,377 bp
Tssr65040	Chr7:24484024-24484030 (+)	7,396 bp
Tssr65041	Chr7:24484051-24484054 (+)	7,422 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24