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Foxn2 Gene Detail
Summary
  • Symbol
    Foxn2
  • Name
    forkhead box N2
  • Synonyms
    3230402J05Rik, 6030465J18Rik, Fkh19, HTLF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347478
    NCBI Gene: 14236
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:88748139-88797961 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 57.97 cM, cytoband E5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1520 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347478
 protein coding gene Chr17:88746430-88797961 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024109
 protein coding gene Chr17:91936712-91984554 (+)
A/J MGP_AJ_G0024069
 protein coding gene Chr17:88962285-89013154 (+)
AKR/J MGP_AKRJ_G0024038
 protein coding gene Chr17:90439882-90487542 (+)
BALB/cJ MGP_BALBcJ_G0024070
 protein coding gene Chr17:88795555-88842554 (+)
C3H/HeJ MGP_C3HHeJ_G0023835
 protein coding gene Chr17:91351271-91398401 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024515
 protein coding gene Chr17:95129905-95181242 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021953
 protein coding gene Chr17:84024338-84067340 (+)
CAST/EiJ MGP_CASTEiJ_G0023314
 protein coding gene Chr17:92207764-92258816 (+)
CBA/J MGP_CBAJ_G0023808
 protein coding gene Chr17:99159160-99206847 (+)
DBA/2J MGP_DBA2J_G0023937
 protein coding gene Chr17:87352944-87400174 (+)
FVB/NJ MGP_FVBNJ_G0023903
 protein coding gene Chr17:86885153-86933346 (+)
LP/J MGP_LPJ_G0024021
 protein coding gene Chr17:92730049-92780409 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023931
 protein coding gene Chr17:98942708-98994368 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024560
 protein coding gene Chr17:91000543-91050699 (+)
PWK/PhJ MGP_PWKPhJ_G0023059
 protein coding gene Chr17:87046130-87095099 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022870
 protein coding gene Chr17:87753382-87797656 (+)
WSB/EiJ MGP_WSBEiJ_G0023380
 protein coding gene Chr17:91853067-91901802 (+)



Homology
more
  • Human Ortholog
    FOXN2, forkhead box N2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXN2, forkhead box N2
  • Synonyms
    HTLF
  • Links
    NCBI Gene ID: 3344
    neXtProt AC: NX_P32314
    UniProt: P32314

  • Chr Location
    2p16.3; chr2:48313659-48379295 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    924
  • Tissues
    73
  • cDNA Data
    17
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034998 Ensembl Gene Model | MGI Sequence Detail 49823 C57BL/6J ±  kb
    transcript ENSMUST00000112238 Ensembl | MGI Sequence Detail 5085 Not Applicable  
    polypeptide ENSMUSP00000107857 Ensembl | MGI Sequence Detail 429 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR047119 Forkhead box protein N2/3-like
      IPR047403 Forkhead box protein N2, forkhead domain
      IPR001766 Fork head domain
      IPR018122 Fork head domain conserved site1
      IPR030456 Fork head domain conserved site 2
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    • GlyGen
      E9Q7L6 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 1
      cDNA 17
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1276569, MGI:1918026, MGI:2442145
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 9
      Gene Ontology 3
      Phenotypes 8
    • Earliest
      J:43593 Schorpp M, et al., Characterization of mouse and human nude genes. Immunogenetics. 1997;46(6):509-15
    • Latest
      J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory