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Foxc2 Gene Detail
Summary
  • Symbol
    Foxc2
  • Name
    forkhead box C2
  • Synonyms
    Fkh14, Hfhbf3, Mfh1, MFH-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347481
    NCBI Gene: 14234
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:121842910-121845634 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 70.33 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    122 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347481
 protein coding gene Chr8:121842910-121845634 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034209
 protein coding gene Chr8:124593540-124596264 (+)
A/J MGP_AJ_G0034189
 protein coding gene Chr8:119413674-119416398 (+)
AKR/J MGP_AKRJ_G0034116
 protein coding gene Chr8:122897753-122900477 (+)
BALB/cJ MGP_BALBcJ_G0034183
 protein coding gene Chr8:119630929-119633653 (+)
C3H/HeJ MGP_C3HHeJ_G0033894
 protein coding gene Chr8:123629088-123631812 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034703
 protein coding gene Chr8:128734023-128736747 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031645
 protein coding gene Chr8:112282297-112285026 (+)
CAST/EiJ MGP_CASTEiJ_G0033221
 protein coding gene Chr8:123644275-123646999 (+)
CBA/J MGP_CBAJ_G0033867
 protein coding gene Chr8:133463119-133465843 (+)
DBA/2J MGP_DBA2J_G0034023
 protein coding gene Chr8:118622920-118625644 (+)
FVB/NJ MGP_FVBNJ_G0033966
 protein coding gene Chr8:117711573-117714297 (+)
LP/J MGP_LPJ_G0034112
 protein coding gene Chr8:124719586-124722310 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034013
 protein coding gene Chr8:135769955-135772679 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034721
 protein coding gene Chr8:123081080-123083805 (+)
PWK/PhJ MGP_PWKPhJ_G0032923
 protein coding gene Chr8:118423411-118426136 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032763
 protein coding gene Chr8:121791089-121793814 (+)
WSB/EiJ MGP_WSBEiJ_G0033337
 protein coding gene Chr8:123830707-123833435 (+)



Homology
more
  • Human Ortholog
    FOXC2, forkhead box C2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXC2, forkhead box C2
  • Synonyms
    FKHL14, LD, MFH-1, MFH1
  • Links
    NCBI Gene ID: 2303
    neXtProt AC: NX_Q99958
    UniProt: Q99958

  • Chr Location
    16q24.1; chr16:86566829-86569728 (+)  GRCh38
Human Diseases
more
  • Diseases
    7 with human FOXC2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    102 phenotypes from 5 alleles in 9 genetic backgrounds
    85 phenotypes from multigenic genotypes
    1 images
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations die perinatally or before with cardiac abnormalities and skeletal defects in the neurocranium and spine. Heterozygotes exhibit lymphatic vessel and lymph node hyperplasia, anterior segment defects, and distichiasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    92
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1382
  • Tissues
    427
  • cDNA Data
    32
  • Literature Summary
    134
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14234 NCBI Gene Model | MGI Sequence Detail 2725 C57BL/6J ±  kb
    transcript NM_013519 RefSeq | MGI Sequence Detail 2739 ZRU/MplStud  
    polypeptide Q61850 UniProt | EBI | MGI Sequence Detail 494 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000007608 forkhead box protein C2
      (term hierarchy)
    • InterPro Domains
      IPR050211 Forkhead box domain-containing protein
      IPR047391 Forkhead box protein C1/C2-like, forkhead domain
      IPR001766 Fork head domain
      IPR018122 Fork head domain conserved site1
      IPR030456 Fork head domain conserved site 2
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    • GlyGen
      Q61850 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 6
      cDNA 33
      Primer pair 4
      Other 7

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38305, MGI:109260
    References
    more
    • Summaries
      All 199
      Developmental Gene Expression 134
      Gene Ontology 21
      Phenotypes 59
    • Earliest
      J:11921 Sasaki H, et al., Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development. 1993 May;118(1):47-59
    • Latest
      J:353623 Almubarak A, et al., FOXC1 and FOXC2 regulate growth plate chondrocyte maturation towards hypertrophy in the embryonic mouse limb skeleton. Development. 2024 Aug 15;151(16)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory