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Ror2 Gene Detail
Summary
  • Symbol
    Ror2
  • Name
    receptor tyrosine kinase-like orphan receptor 2
  • Synonyms
    Ntrkr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347521
    NCBI Gene: 26564
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:53263353-53440160 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 27.68 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5275 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347521
 protein coding gene Chr13:53263348-53440160 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020560
 protein coding gene Chr13:52422827-52612873 (-)
A/J MGP_AJ_G0020514
 protein coding gene Chr13:50535252-50712690 (-)
AKR/J MGP_AKRJ_G0020492
 protein coding gene Chr13:51972713-52154942 (-)
BALB/cJ MGP_BALBcJ_G0020510
 protein coding gene Chr13:50748605-50926883 (-)
C3H/HeJ MGP_C3HHeJ_G0020309
 protein coding gene Chr13:51819656-52004561 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020944
 protein coding gene Chr13:54040729-54227387 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018526
 protein coding gene Chr13:48316291-48492723 (-)
CAST/EiJ MGP_CASTEiJ_G0019823
 protein coding gene Chr13:51828614-52018502 (-)
CBA/J MGP_CBAJ_G0020269
 protein coding gene Chr13:56069128-56278049 (-)
DBA/2J MGP_DBA2J_G0020392
 protein coding gene Chr13:50102097-50279950 (-)
FVB/NJ MGP_FVBNJ_G0020371
 protein coding gene Chr13:49546410-49724161 (-)
LP/J MGP_LPJ_G0020468
 protein coding gene Chr13:52693266-52881432 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020400
 protein coding gene Chr13:55641461-55831384 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020987
 protein coding gene Chr13:51582061-51772618 (-)
PWK/PhJ MGP_PWKPhJ_G0019579
 protein coding gene Chr13:50049300-50233407 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019406
 protein coding gene Chr13:50480514-50673304 (-)
WSB/EiJ MGP_WSBEiJ_G0019885
 protein coding gene Chr13:51895657-52088988 (-)



Homology
more
  • Human Ortholog
    ROR2, receptor tyrosine kinase like orphan receptor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ROR2, receptor tyrosine kinase like orphan receptor 2
  • Synonyms
    BDB, BDB1, NTRKR2
  • Links
    NCBI Gene ID: 4920
    neXtProt AC: NX_Q01974
    UniProt: Q01974

  • Chr Location
    9q22.31; chr9:91563091-91950228 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ror2 mouse models; 3 with human ROR2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 1 "NOT" model
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    139 phenotypes from 7 alleles in 6 genetic backgrounds
    23 phenotypes from multigenic genotypes
    9 images
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for some disruptions in this gene die within the first few hours after birth. They display respiratory and cardiovascular abnormalities as well as a variety of skeletal defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    91
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1174
  • Tissues
    330
  • cDNA Data
    41
  • Literature Summary
    53
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26564 NCBI Gene Model | MGI Sequence Detail 176808 C57BL/6J ±  kb
    transcript NM_013846 RefSeq | MGI Sequence Detail 3985 ZRU/MplStud  
    polypeptide Q9Z138 UniProt | EBI | MGI Sequence Detail 944 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 41
      Primer pair 4
      Other 10

      Microarray probesets 6
    References
    more
    • Summaries
      All 139
      Developmental Gene Expression 53
      Diseases 2
      Gene Ontology 17
      Phenotypes 66
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:350324 Polsani N, et al., Mesenchymal Wnts are required for morphogenetic movements of calvarial osteoblasts during apical expansion. Development. 2024 Jun 15;151(12):dev202596
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory