Tpsg1 MGI Mouse Gene Detail - MGI:1349391

Symbol

Tpsg1
Name

tryptase gamma 1
Synonyms

Prss31, TMT

Feature Type

protein coding gene
IDs

MGI:1349391
NCBI Gene: 26945
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:25588235-25593417 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 12.53 cM, cytoband A3.3
Mapping Data

4 experiments

SNPs within 2kb

234 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1349391	protein coding gene	Chr17:25588169-25593417 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023354	protein coding gene	Chr17:24432732-24437888 (+)
A/J	MGP_AJ_G0023313	protein coding gene	Chr17:23740631-23745780 (+)
AKR/J	MGP_AKRJ_G0023279	protein coding gene	Chr17:23840017-23845197 (+)
BALB/cJ	MGP_BALBcJ_G0023318	protein coding gene	Chr17:23947633-23952793 (+)
C3H/HeJ	MGP_C3HHeJ_G0023078	protein coding gene	Chr17:24213714-24218868 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023760	protein coding gene	Chr17:25494083-25499254 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021236	protein coding gene	Chr17:21202089-21207294 (+)
CAST/EiJ	MGP_CASTEiJ_G0022580	protein coding gene	Chr17:24082640-24087864 (+)
CBA/J	MGP_CBAJ_G0023053	protein coding gene	Chr17:26359152-26364312 (+)
DBA/2J	MGP_DBA2J_G0023183	protein coding gene	Chr17:23337284-23342471 (+)
FVB/NJ	MGP_FVBNJ_G0023153	protein coding gene	Chr17:23054990-23060149 (+)
LP/J	MGP_LPJ_G0023260	protein coding gene	Chr17:24722599-24727775 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023172	protein coding gene	Chr17:26013919-26019056 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023800	protein coding gene	Chr17:24126629-24131790 (+)
PWK/PhJ	MGP_PWKPhJ_G0022329	protein coding gene	Chr17:22091820-22097047 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022147	protein coding gene	Chr17:22211406-22217402 (+)
WSB/EiJ	MGP_WSBEiJ_G0022643	protein coding gene	Chr17:24192510-24197647 (+)

Human Ortholog

TPSG1, tryptase gamma 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TPSG1, tryptase gamma 1
Synonyms

PRSS31, TMT, trpA
Links

HGNC:14134

NCBI Gene ID: 25823

neXtProt AC: NX_Q9NRR2

UniProt: Q9NRR2
Chr Location

16p13.3; chr16:1221651-1225793 (-) GRCh38

MGI Vertebrate Homology

Tpsg1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TPSG1
Gene Tree

Tpsg1

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Radiation induced

2
Targeted

3
Genomic Mutations

2 involving Tpsg1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout affects lung parameters after methacholine challenge and reduces susceptibility to smoke-induced COPD and DSS-induced colitis.

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All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

12
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tpsg1

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All Sequences

64
RefSeq

16
UniProt

6
CCDS

CCDS28518.1, CCDS89021.1

Ensembl

ENSMUSG00000033200 (Evidence)
NCBI Gene

26945

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033200	Ensembl Gene Model \| MGI Sequence Detail	5183	C57BL/6J	± kb
transcript	ENSMUST00000024999	Ensembl \| MGI Sequence Detail	1214	Not Applicable
polypeptide	ENSMUSP00000024999	Ensembl \| MGI Sequence Detail	311	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000016593 tryptase gamma

(term hierarchy)
EC

3.4.21.-
InterPro Domains

IPR001314 Peptidase S1A, chymotrypsin family

IPR009003 Peptidase S1, PA clan

IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold

IPR050127 Serine Proteases (Peptidase S1 Family)

IPR001254 Serine proteases, trypsin domain

IPR018114 Serine proteases, trypsin family, histidine active site
GlyGen

Q9QUL7 2 sites

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All nucleic 14

Genomic 1

cDNA 12

Primer pair 1

Microarray probesets 2

Summaries

All 32

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 7
Earliest

J:58140 Wong GW, et al., Identification of a new member of the tryptase family of mouse and human mast cell proteases which possesses a novel COOH-terminal hydrophobic extension. J Biol Chem. 1999 Oct 22;274(43):30784-93
Latest

J:347984 Naillat F, et al., Calcium signaling induces partial EMT and renal fibrosis in a Wnt4(mCherry) knock-in mouse model. Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21;1870(5):167180

TSS for Tpsg1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143155	Chr17:25588241-25588254 (+)	13 bp
Tssr143156	Chr17:25588302-25588311 (+)	72 bp
Tssr143157	Chr17:25589524-25589540 (+)	1,297 bp
Tssr143158	Chr17:25589549-25589573 (+)	1,326 bp
Tssr5039	Chr17:25589588-25589607 (+)	1,363 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24