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Macroh2a1 Gene Detail
Summary
  • Symbol
    Macroh2a1
  • Name
    macroH2A.1 histone
  • Synonyms
    H2AF12M, H2afy, MACROH2A1.2, mH2a1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349392
    NCBI Gene: 26914
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:56221435-56283439 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 30.06 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1621 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349392
 protein coding gene Chr13:56221432-56284174 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020613
 protein coding gene Chr13:55596927-55660780 (-)
A/J MGP_AJ_G0020567
 protein coding gene Chr13:53538566-53601464 (-)
AKR/J MGP_AKRJ_G0020545
 protein coding gene Chr13:55126610-55191418 (-)
BALB/cJ MGP_BALBcJ_G0020563
 protein coding gene Chr13:53770265-53832603 (-)
C3H/HeJ MGP_C3HHeJ_G0020362
 protein coding gene Chr13:54936128-54998003 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020997
 protein coding gene Chr13:57285662-57349194 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018579
 protein coding gene Chr13:51470829-51534468 (-)
CAST/EiJ MGP_CASTEiJ_G0019876
 protein coding gene Chr13:55045234-55108321 (-)
CBA/J MGP_CBAJ_G0020322
 protein coding gene Chr13:59477144-59543942 (-)
DBA/2J MGP_DBA2J_G0020445
 protein coding gene Chr13:53085700-53148585 (-)
FVB/NJ MGP_FVBNJ_G0020424
 protein coding gene Chr13:52553879-52616112 (-)
LP/J MGP_LPJ_G0020521
 protein coding gene Chr13:55852788-55917836 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020453
 protein coding gene Chr13:58903644-58967469 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021040
 protein coding gene Chr13:54706379-54770485 (-)
PWK/PhJ MGP_PWKPhJ_G0019632
 protein coding gene Chr13:53114328-53177463 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019459
 protein coding gene Chr13:53568532-53700216 (-)
WSB/EiJ MGP_WSBEiJ_G0019938
 protein coding gene Chr13:55072927-55138597 (-)



Homology
more
  • Human Ortholog
    MACROH2A1, macroH2A.1 histone
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MACROH2A1, macroH2A.1 histone
  • Synonyms
    H2AF12M, H2AFY, H2A.y, H2A/y, MACROH2A1.1, macroH2A1.2, mH2A1
  • Links
    NCBI Gene ID: 9555
    neXtProt AC: NX_O75367
    UniProt: O75367

  • Chr Location
    5q31.1; chr5:135334381-135399914 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Macroh2a1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    12 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele are viable and fertile and display no gross phenotypic abnormalities. Mice homozygous for a different knock-out allele exhibit female-specific hepatic steatosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    83
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    905
  • Tissues
    164
  • cDNA Data
    14
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26914 NCBI Gene Model | MGI Sequence Detail 62005 C57BL/6J ±  kb
    transcript NM_012015 RefSeq | MGI Sequence Detail 1978 C57BL/6  
    polypeptide Q9QZQ8 UniProt | EBI | MGI Sequence Detail 369 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 14
      Primer pair 5
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:6325042
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 15
      Phenotypes 24
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:345376 Filipescu D, et al., MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping. Nat Cell Biol. 2023 Sep;25(9):1332-1345
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory