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Ddx3y Gene Detail
Summary
  • Symbol
    Ddx3y
  • Name
    DEAD box helicase 3, Y-linked
  • Synonyms
    8030469F12Rik, D1Pas1-rs1, Dby, DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349406
    NCBI Gene: 26900
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrY:1260771-1286629 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome Y, cytoband p
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    45 from dbSNP Build 142
  • Strain Annotations
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349406
 protein coding gene ChrY:1260715-1286630 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    DDX3Y, DEAD-box helicase 3 Y-linked
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDX3Y, DEAD-box helicase 3 Y-linked
  • Synonyms
    DBY
  • Links
    NCBI Gene ID: 8653
    neXtProt AC: NX_O15523
    UniProt: O15523

  • Chr Location
    Yq11.221; chrY:12903999-12920478 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    13 phenotype references
Knock-out males exhibit normal spermatogenesis and fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    781
  • Tissues
    27
  • cDNA Data
    58
  • Literature Summary
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000069045 Ensembl Gene Model | MGI Sequence Detail 25859 C57BL/6J ±  kb
transcript ENSMUST00000091190 Ensembl | MGI Sequence Detail 4600 Not Applicable  
polypeptide ENSMUSP00000088729 Ensembl | MGI Sequence Detail 658 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000006365 ATP-dependent RNA helicase DDX3Y
    (term hierarchy)
  • EC
    3.6.4.13
  • InterPro Domains
    IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
    IPR011545 DEAD/DEAH box helicase domain
    IPR001650 Helicase, C-terminal domain-like
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR014014 RNA helicase, DEAD-box type, Q motif
  • GlyGen
    Q62095 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 66
    Genomic 2
    cDNA 58
    Primer pair 5
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-16301, MGI:1924744, MGI:99524
References
more
  • Summaries
    All 54
    Developmental Gene Expression 10
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:17429 Gee SL, et al., Mouse erythroid cells express multiple putative RNA helicase genes exhibiting high sequence conservation from yeast to mammals. Gene. 1994 Mar 25;140(2):171-7
  • Latest
    J:335100 Hirata W, et al., Generation of the Y-chromosome linked red fluorescent protein transgenic mouse model and sexing at the preimplantation stage. Exp Anim. 2022;71(1):82-89
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory