Triobp MGI Mouse Gene Detail - MGI:1349410 - TRIO and F-actin binding protein

Symbol

Triobp
Name

TRIO and F-actin binding protein
Synonyms

EST478828, Mus EST 478828, Tara

Feature Type

protein coding gene
IDs

MGI:1349410
NCBI Gene: 110253
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr15:78831924-78890069 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.70 cM
Mapping Data

3 experiments

SNPs within 2kb

1601 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1349410	protein coding gene	Chr15:78831924-78890069 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022059	protein coding gene	Chr15:79189346-79249117 (+)
A/J	MGP_AJ_G0022020	protein coding gene	Chr15:76460429-76518680 (+)
AKR/J	MGP_AKRJ_G0021995	protein coding gene	Chr15:78576661-78637378 (+)
BALB/cJ	MGP_BALBcJ_G0022026	protein coding gene	Chr15:76428700-76491442 (+)
C3H/HeJ	MGP_C3HHeJ_G0021797	protein coding gene	Chr15:78580038-78641802 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022469	protein coding gene	Chr15:82305653-82365168 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019999	protein coding gene	Chr15:72946569-73005851 (+)
CAST/EiJ	MGP_CASTEiJ_G0021318	protein coding gene	Chr15:79269934-79330312 (+)
CBA/J	MGP_CBAJ_G0021762	protein coding gene	Chr15:84849192-84914797 (+)
DBA/2J	MGP_DBA2J_G0021891	protein coding gene	Chr15:75940802-75999488 (+)
FVB/NJ	MGP_FVBNJ_G0021869	protein coding gene	Chr15:74957979-75017840 (+)
LP/J	MGP_LPJ_G0021959	protein coding gene	Chr15:79383336-79445056 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021889	protein coding gene	Chr15:90014855-90074016 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022483	protein coding gene	Chr15:78600965-78662247 (+)
PWK/PhJ	MGP_PWKPhJ_G0021060	protein coding gene	Chr15:75940503-76002458 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020897	protein coding gene	Chr15:78383753-78446265 (+)
WSB/EiJ	MGP_WSBEiJ_G0021370	protein coding gene	Chr15:78973303-79032921 (+)

Human Ortholog

TRIOBP, TRIO and F-actin binding protein

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRIOBP, TRIO and F-actin binding protein
Synonyms

DFNB28, dJ37E16.4, HRIHFB2122, TAP68, TARA
Links

HGNC:17009

NCBI Gene ID: 11078

neXtProt AC: NX_Q9H2D6

UniProt: Q9H2D6
Chr Location

22q13.1; chr22:37697048-37776556 (+) GRCh38

MGI Vertebrate Homology

Triobp stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TRIOBP
Gene Tree

Triobp

Diseases

1 with Triobp mouse models; 1 with human TRIOBP associations

Human Disease

Mouse Models

autosomal recessive nonsyndromic deafness 28

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

16 phenotypes from 4 alleles in 3 genetic backgrounds
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

7
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Triobp
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

74 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for gene trapped alleles exhibit embryonic lethality. Mice homozygous for a targeted allele eliminating isoforms 4 and 5 exhibit profound deafness associated with stereocilia fragility and degeneration.

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All GO Annotations

24
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

99
Literature Summary

4

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase triobp

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All Sequences

111
RefSeq

28
UniProt

7
CCDS

CCDS37136.1, CCDS37137.1, CCDS37138.1, CCDS88802.1

Ensembl

ENSMUSG00000033088 (Evidence)
NCBI Gene

110253

			Length	Strain/Species	Flank
genomic	110253	NCBI Gene Model \| MGI Sequence Detail	58146	C57BL/6J	± kb
transcript	NM_001039156	RefSeq \| MGI Sequence Detail	7352	ZRU/MplStud
polypeptide	Q99KW3	UniProt \| EBI \| MGI Sequence Detail	2014	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000016669 TRIO and F-actin-binding protein

(term hierarchy)
InterPro Domains

IPR052223 Actin Cytoskeleton Regulatory

IPR039597 Myosin phosphatase-RhoA interacting protein, PH domain

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain
GlyGen

Q99KW3 1 site, 1 O-linked glycan (1 site)

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All nucleic 99

cDNA 99

Microarray probesets 3

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MGI:1349446, MGI:2146002

Summaries

All 70

Developmental Gene Expression 4

Diseases 2

Gene Ontology 10

Phenotypes 34
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Triobp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132023	Chr15:78832090-78832097 (+)	170 bp
Tssr132024	Chr15:78832111-78832134 (+)	199 bp
Tssr132025	Chr15:78832137-78832146 (+)	218 bp
Tssr132026	Chr15:78832147-78832160 (+)	230 bp
Tssr4653	Chr15:78844128-78844139 (+)	12,210 bp
Tssr132027	Chr15:78844142-78844162 (+)	12,228 bp
Tssr132028	Chr15:78851532-78851535 (+)	19,610 bp
Tssr132029	Chr15:78851697-78851700 (+)	19,775 bp
Tssr4654	Chr15:78857255-78857263 (+)	25,335 bp
Tssr132030	Chr15:78867248-78867320 (+)	35,360 bp
Tssr132031	Chr15:78871283-78871303 (+)	39,369 bp
Tssr132032	Chr15:78871304-78871320 (+)	39,388 bp
Tssr132033	Chr15:78871327-78871337 (+)	39,408 bp
Tssr132035	Chr15:78886480-78886496 (+)	54,564 bp
Tssr132036	Chr15:78886498-78886516 (+)	54,583 bp
Tssr132037	Chr15:78886519-78886531 (+)	54,601 bp
Tssr132038	Chr15:78886538-78886552 (+)	54,621 bp
Tssr132039	Chr15:78889438-78889518 (+)	57,554 bp
Tssr132040	Chr15:78889674-78889691 (+)	57,759 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24