Clec4a2 MGI Mouse Gene Detail - MGI:1349412 - C-type lectin domain family 4, member a2

Symbol

Clec4a2
Name

C-type lectin domain family 4, member a2
Synonyms

Clecsf6, DCIR, Dcir1, dendritic cell immunoreceptor

Feature Type

protein coding gene
IDs

MGI:1349412
NCBI Gene: 26888
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr6:123099627-123119891 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 58.18 cM, cytoband F3
Mapping Data

3 experiments

SNPs within 2kb

690 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1349412	protein coding gene	Chr6:123083387-123120958 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031240	protein coding gene	Chr6:126248285-126293614 (+)
A/J	MGP_AJ_G0031209	protein coding gene	Chr6:121433922-121466762 (+)
AKR/J	MGP_AKRJ_G0031139	protein coding gene	Chr6:124800311-124840014 (+)
BALB/cJ	MGP_BALBcJ_G0031219	protein coding gene	Chr6:121160473-121190229 (+)
C3H/HeJ	MGP_C3HHeJ_G0030938	protein coding gene	Chr6:124757535-124791528 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031678	protein coding gene	Chr6:129573887-129609412 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028833	protein coding gene	Chr6:118027577-118045381 (+)
CAST/EiJ	MGP_CASTEiJ_G0030327	protein coding gene	Chr6:125026259-125063512 (+)
CBA/J	MGP_CBAJ_G0030901	protein coding gene	Chr6:134631708-134688586 (+)
DBA/2J	MGP_DBA2J_G0031057	protein coding gene	Chr6:120380123-120417440 (+)
FVB/NJ	no annotation
LP/J	MGP_LPJ_G0031138	protein coding gene	Chr6:126428535-126459776 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031045	protein coding gene	Chr6:138577229-138618609 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031707	protein coding gene	Chr6:124693204-124729314 (+)
PWK/PhJ	MGP_PWKPhJ_G0030041	protein coding gene	Chr6:119211693-119237364 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029868	protein coding gene	Chr6:122817408-122855180 (+)
WSB/EiJ	MGP_WSBEiJ_G0030409	protein coding gene	Chr6:124994888-125032477 (+)

Human Ortholog

CLEC4A, C-type lectin domain family 4 member A

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CLEC4A, C-type lectin domain family 4 member A
Synonyms

CD367, CLECSF6, DCIR, DDB27, HDCGC13P, hDCIR, LLIR
Links

HGNC:13257

NCBI Gene ID: 50856

neXtProt AC: NX_Q9UMR7

UniProt: Q9UMR7
Chr Location

12p13.31; chr12:8102907-8138607 (+) GRCh38

MGI Vertebrate Homology

Clec4a2 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: CLEC4A
Gene Tree

Clec4a2

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Phenotype Summary

28 phenotypes from 2 alleles in 2 genetic backgrounds
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

4
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased IgG2a, IgG2b and IgG3 levels, increased B cell proliferation, enlarged lymph nodes and degeneration of seminiferous tubules.

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All GO Annotations

25
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

19

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

58
RefSeq

14
UniProt

5
CCDS

CCDS20510.1, CCDS51894.1

Ensembl

ENSMUSG00000030148 (Evidence)
NCBI Gene

26888

			Length	Strain/Species	Flank
genomic	26888	NCBI Gene Model \| MGI Sequence Detail	20265	C57BL/6J	± kb
transcript	NM_001170333	RefSeq \| MGI Sequence Detail	1473	ZRU/MplStud
polypeptide	Q9QZ15	UniProt \| EBI \| MGI Sequence Detail	238	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000005568 C-type lectin domain family 4 member A

(term hierarchy)
InterPro Domains

IPR033989 CD209-like, C-type lectin-like domain

IPR050111 C-type lectin and snaclec domain-containing protein

IPR018378 C-type lectin, conserved site

IPR016187 C-type lectin fold

IPR001304 C-type lectin-like

IPR016186 C-type lectin-like/link domain superfamily

IPR051379 C-type Lectin Receptor Immune Modulators
GlyGen

Q9QZ15 4 sites, 3 N-linked glycans (2 sites)

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All nucleic 19

cDNA 19

Microarray probesets 5

Summaries

All 51

Gene Ontology 6

Phenotypes 24
Earliest

J:56741 Bates EE, et al., APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif. J Immunol. 1999 Aug 15;163(4):1973-83
Latest

J:346737 Trimaglio G, et al., The C-type lectin DCIR contributes to the immune response and pathogenesis of colorectal cancer. Sci Rep. 2024 Mar 26;14(1):7199

TSS for Clec4a2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58750	Chr6:123099615-123099691 (+)	26 bp
Tssr58751	Chr6:123100272-123100301 (+)	660 bp
Tssr58752	Chr6:123100312-123100328 (+)	693 bp
Tssr58753	Chr6:123100344-123100375 (+)	733 bp
Tssr58754	Chr6:123100382-123100443 (+)	786 bp
Tssr58755	Chr6:123100473-123100487 (+)	853 bp
Tssr58756	Chr6:123100512-123100523 (+)	891 bp
Tssr58757	Chr6:123101389-123101400 (+)	1,768 bp
Tssr58758	Chr6:123101473-123101488 (+)	1,854 bp
Tssr58759	Chr6:123101499-123101523 (+)	1,884 bp
Tssr58760	Chr6:123106768-123106777 (+)	7,146 bp
Tssr58761	Chr6:123115368-123115386 (+)	15,750 bp
Tssr58762	Chr6:123115391-123115403 (+)	15,770 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24