Haao MGI Mouse Gene Detail - MGI:1349444 - 3-hydroxyanthranilate 3,4-dioxygenase

Symbol

Haao
Name

3-hydroxyanthranilate 3,4-dioxygenase
Synonyms

0610007K21Rik, 0610012J07Rik, 3-HAO, 3HAO, 3-HAOxase

Feature Type

protein coding gene
IDs

MGI:1349444
NCBI Gene: 107766
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr17:84138585-84155392 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 54.85 cM, cytoband E4
Mapping Data

2 experiments

SNPs within 2kb

720 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1349444	protein coding gene	Chr17:84138585-84157589 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024076	protein coding gene	Chr17:86942261-86960418 (-)
A/J	MGP_AJ_G0024035	protein coding gene	Chr17:84208374-84225034 (-)
AKR/J	MGP_AKRJ_G0024004	protein coding gene	Chr17:85562439-85579810 (-)
BALB/cJ	MGP_BALBcJ_G0024036	protein coding gene	Chr17:84064947-84080089 (-)
C3H/HeJ	MGP_C3HHeJ_G0023801	protein coding gene	Chr17:86416683-86433174 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024481	protein coding gene	Chr17:90059031-90075594 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021920	protein coding gene	Chr17:79419810-79435439 (-)
CAST/EiJ	MGP_CASTEiJ_G0023280	protein coding gene	Chr17:87156668-87174797 (-)
CBA/J	MGP_CBAJ_G0023775	protein coding gene	Chr17:93766814-93785617 (-)
DBA/2J	MGP_DBA2J_G0023903	protein coding gene	Chr17:82696907-82712201 (-)
FVB/NJ	MGP_FVBNJ_G0023869	protein coding gene	Chr17:82174021-82189936 (-)
LP/J	MGP_LPJ_G0023987	protein coding gene	Chr17:87693456-87713031 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023897	protein coding gene	Chr17:93904606-93919969 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024526	protein coding gene	Chr17:86063118-86079427 (-)
PWK/PhJ	MGP_PWKPhJ_G0023025	protein coding gene	Chr17:82249002-82266408 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022836	protein coding gene	Chr17:82839497-82854862 (-)
WSB/EiJ	MGP_WSBEiJ_G0023347	protein coding gene	Chr17:86910142-86928438 (-)

Human Ortholog

HAAO, 3-hydroxyanthranilate 3,4-dioxygenase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HAAO, 3-hydroxyanthranilate 3,4-dioxygenase
Synonyms

3-HAO, h3HAO, HAO, VCRL1
Links

HGNC:4796

NCBI Gene ID: 23498

neXtProt AC: NX_P46952

UniProt: P46952
Chr Location

2p21; chr2:42767089-42792593 (-) GRCh38

MGI Vertebrate Homology

Haao stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HAAO
Protein SuperFamily

3hydroanth_dOase_animal
Gene Tree

Haao

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Phenotype Summary

14 phenotypes from 3 alleles in 3 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced LPS-induced depressive behaviors and altered kynurenine metabolism.

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All GO Annotations

28
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

808
Tissues

99
cDNA Data

96
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase haao

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All Sequences

53
RefSeq

12
UniProt

4
CCDS

CCDS37709.1

Ensembl

ENSMUSG00000000673 (Evidence)
NCBI Gene

107766

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000673	Ensembl Gene Model \| MGI Sequence Detail	16808	C57BL/6J	± kb
transcript	ENSMUST00000000687	Ensembl \| MGI Sequence Detail	1381	Not Applicable
polypeptide	ENSMUSP00000000687	Ensembl \| MGI Sequence Detail	286	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008427 3-hydroxyanthranilate 3,4-dioxygenase

(term hierarchy)
EC

1.13.11.6
InterPro Domains

IPR016700 3-hydroxyanthranilate 3, 4-dioxygenase, metazoan

IPR010329 3-hydroxyanthranilic acid dioxygenase

IPR011051 RmlC-like cupin domain superfamily

IPR014710 RmlC-like jelly roll fold
GlyGen

Q78JT3 1 site, 1 O-linked glycan (1 site)

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All nucleic 98

Genomic 2

cDNA 96

Microarray probesets 3

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MGI:1913307, MGI:1918919

Summaries

All 48

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 13
Earliest

J:131587 Nakano K, et al., Abnormally high activity of 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice. Brain Res. 1992 Feb 14;572(1-2):1-4
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Haao:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr149617	Chr17:84155316-84155352 (-)	58 bp
Tssr149616	Chr17:84154318-84154334 (-)	1,066 bp
Tssr149615	Chr17:84154299-84154308 (-)	1,088 bp
Tssr149614	Chr17:84154198-84154239 (-)	1,173 bp
Tssr149613	Chr17:84154191-84154194 (-)	1,199 bp
Tssr149612	Chr17:84154175-84154186 (-)	1,211 bp
Tssr149611	Chr17:84154158-84154171 (-)	1,227 bp
Tssr149610	Chr17:84144759-84144762 (-)	10,631 bp
Tssr149609	Chr17:84139283-84139330 (-)	16,085 bp
Tssr149608	Chr17:84139126-84139145 (-)	16,256 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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