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Cenph Gene Detail
Summary
  • Symbol
    Cenph
  • Name
    centromere protein H
  • Synonyms
    1700021I11Rik, 2410018A12Rik, 2610042E16Rik, 2810046K12Rik, CENP-H, ENP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349448
    NCBI Gene: 26886
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:100896182-100912407 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 53.23 cM, cytoband D1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    630 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349448
 protein coding gene Chr13:100896182-100912415 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020894
 protein coding gene Chr13:102694386-102710166 (-)
A/J MGP_AJ_G0020845
 protein coding gene Chr13:98704766-98721898 (-)
AKR/J MGP_AKRJ_G0020820
 protein coding gene Chr13:101729367-101749082 (-)
BALB/cJ MGP_BALBcJ_G0020845
 protein coding gene Chr13:99434813-99451429 (-)
C3H/HeJ MGP_C3HHeJ_G0020634
 protein coding gene Chr13:101441831-101457671 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021279
 protein coding gene Chr13:105756421-105790604 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018849
 protein coding gene Chr13:94524031-94539699 (-)
CAST/EiJ MGP_CASTEiJ_G0020153
 protein coding gene Chr13:100909370-100927500 (-)
CBA/J MGP_CBAJ_G0020596
 protein coding gene Chr13:109935921-109955956 (-)
DBA/2J MGP_DBA2J_G0020720
 protein coding gene Chr13:98479599-98502050 (-)
FVB/NJ MGP_FVBNJ_G0020702
 protein coding gene Chr13:97222087-97238688 (-)
LP/J MGP_LPJ_G0020794
 protein coding gene Chr13:102725096-102743013 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020730
 protein coding gene Chr13:110172615-110190262 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021318
 protein coding gene Chr13:101187976-101204728 (-)
PWK/PhJ MGP_PWKPhJ_G0019906
 protein coding gene Chr13:97212868-97230851 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019728
 protein coding gene Chr13:97416477-97433710 (-)
WSB/EiJ MGP_WSBEiJ_G0020211
 protein coding gene Chr13:101658343-101677528 (-)



Homology
more
  • Human Ortholog
    CENPH, centromere protein H
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CENPH, centromere protein H
  • Links
    NCBI Gene ID: 64946
    neXtProt AC: NX_Q9H3R5
    UniProt: Q9H3R5

  • Chr Location
    5q13.2; chr5:69189574-69210357 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    786
  • Tissues
    29
  • cDNA Data
    40
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045273 Ensembl Gene Model | MGI Sequence Detail 16226 C57BL/6J ±  kb
    transcript ENSMUST00000075550 Ensembl | MGI Sequence Detail 1251 Not Applicable  
    polypeptide ENSMUSP00000074988 Ensembl | MGI Sequence Detail 241 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      cDNA 43
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1915102, MGI:1917572, MGI:1919934, MGI:1924184, MGI:2145375
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:57771 Sugata N, et al., Characterization of a novel kinetochore protein, CENP-H. J Biol Chem. 1999 Sep 24;274(39):27343-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory