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Vat1 Gene Detail
Summary
  • Symbol
    Vat1
  • Name
    vesicle amine transport 1
  • Synonyms
    VAT-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349450
    NCBI Gene: 26949
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:101349574-101357025 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 65.10 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    215 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349450
 protein coding gene Chr11:101349571-101357056 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019204
 protein coding gene Chr11:104326772-104334237 (-)
A/J MGP_AJ_G0019172
 protein coding gene Chr11:99940573-99947990 (-)
AKR/J MGP_AKRJ_G0019141
 protein coding gene Chr11:103047078-103054561 (-)
BALB/cJ MGP_BALBcJ_G0019146
 protein coding gene Chr11:100433033-100440518 (-)
C3H/HeJ MGP_C3HHeJ_G0018955
 protein coding gene Chr11:103223632-103231115 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019595
 protein coding gene Chr11:107601426-107608911 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017221
 protein coding gene Chr11:97338356-97346005 (-)
CAST/EiJ MGP_CASTEiJ_G0018509
 protein coding gene Chr11:104202313-104209947 (-)
CBA/J MGP_CBAJ_G0018924
 protein coding gene Chr11:112029980-112037465 (-)
DBA/2J MGP_DBA2J_G0019036
 protein coding gene Chr11:99462593-99470076 (-)
FVB/NJ MGP_FVBNJ_G0019026
 protein coding gene Chr11:99004937-99012355 (-)
LP/J MGP_LPJ_G0019105
 protein coding gene Chr11:104866351-104873812 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019057
 protein coding gene Chr11:111585912-111593395 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019633
 protein coding gene Chr11:103376705-103384186 (-)
PWK/PhJ MGP_PWKPhJ_G0018272
 protein coding gene Chr11:100524848-100532178 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018064
 protein coding gene Chr11:103100078-103110853 (-)
WSB/EiJ MGP_WSBEiJ_G0018558
 protein coding gene Chr11:103372024-103380668 (-)



Homology
more
  • Human Ortholog
    VAT1, vesicle amine transport 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VAT1, vesicle amine transport 1
  • Synonyms
    VATI
  • Links
    NCBI Gene ID: 10493
    neXtProt AC: NX_Q99536
    UniProt: Q99536

  • Chr Location
    17q21.31; chr17:43014607-43025123 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    5
  • cDNA Data
    144
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 26949 NCBI Gene Model | MGI Sequence Detail 7452 C57BL/6J ±  kb
transcript NM_012037 RefSeq | MGI Sequence Detail 2732 C57BL/6  
polypeptide Q62465 UniProt | EBI | MGI Sequence Detail 406 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000017264 synaptic vesicle membrane protein VAT-1
    (term hierarchy)
  • EC
    1.-.-.-
  • InterPro Domains
    IPR013154 Alcohol dehydrogenase-like, N-terminal
    IPR011032 GroES-like superfamily
    IPR036291 NAD(P)-binding domain superfamily
    IPR020843 Polyketide synthase, enoylreductase domain
    IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site
    IPR052100 Synaptic vesicle ATPase and mitochondrial regulator
  • GlyGen
    Q62465 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 146
    Genomic 2
    cDNA 144

    Microarray probesets 3
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:57580 Hayess K, et al., Mammalian protein homologous to VAT-1 of Torpedo californica: isolation from Ehrlich ascites tumor cells, biochemical characterization, and organization of its gene. J Cell Biochem. 1998 Jun 1;69(3):304-15
  • Latest
    J:345261 Jia L, et al., MiR-34a Regulates Axonal Growth of Dorsal Root Ganglia Neurons by Targeting FOXP2 and VAT1 in Postnatal and Adult Mouse. Mol Neurobiol. 2018 Dec;55(12):9089-9099
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory