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Corin Gene Detail
Summary
  • Symbol
    Corin
  • Name
    corin, serine peptidase
  • Synonyms
    Lrp4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349451
    NCBI Gene: 53419
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:72457368-72661816 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 38.44 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5984 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349451
 protein coding gene Chr5:72457291-72661884 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029611
 protein coding gene Chr5:72212292-72423412 (-)
A/J MGP_AJ_G0029579
 protein coding gene Chr5:69515222-69722903 (-)
AKR/J MGP_AKRJ_G0029527
 protein coding gene Chr5:71743415-71961737 (-)
BALB/cJ MGP_BALBcJ_G0029588
 protein coding gene Chr5:70182514-70417888 (-)
C3H/HeJ MGP_C3HHeJ_G0029311
 protein coding gene Chr5:72105171-72315254 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030042
 protein coding gene Chr5:75202926-75431880 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027282
 protein coding gene Chr5:65243884-65445309 (-)
CAST/EiJ MGP_CASTEiJ_G0028719
 protein coding gene Chr5:71219719-71438824 (-)
CBA/J MGP_CBAJ_G0029280
 protein coding gene Chr5:77603030-77844273 (-)
DBA/2J MGP_DBA2J_G0029426
 protein coding gene Chr5:69573613-69772362 (-)
FVB/NJ MGP_FVBNJ_G0029386
 protein coding gene Chr5:68751602-68960257 (-)
LP/J MGP_LPJ_G0029511
 protein coding gene Chr5:72699452-72903290 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029414
 protein coding gene Chr5:80994936-81206415 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030075
 protein coding gene Chr5:71326655-71540152 (-)
PWK/PhJ MGP_PWKPhJ_G0028443
 protein coding gene Chr5:68541211-68743373 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028277
 protein coding gene Chr5:70697882-70913946 (-)
WSB/EiJ MGP_WSBEiJ_G0028799
 protein coding gene Chr5:71573211-71794762 (-)



Homology
more
  • Human Ortholog
    CORIN, corin, serine peptidase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CORIN, corin, serine peptidase
  • Synonyms
    ATC2, CMH30, CRN, Lrp4, PEE5, TMPRSS10
  • Links
    NCBI Gene ID: 10699
    neXtProt AC: NX_Q9Y5Q5
    UniProt: Q9Y5Q5

  • Chr Location
    4p12; chr4:47593999-47838106 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human CORIN associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display hypertension that is enhanced by high-salt diet and pregnancy, increased body weight, and cardiac hypertrophy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    783
  • Tissues
    47
  • cDNA Data
    10
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005220 Ensembl Gene Model | MGI Sequence Detail 204449 C57BL/6J ±  kb
    transcript ENSMUST00000005352 Ensembl | MGI Sequence Detail 4862 Not Applicable  
    polypeptide ENSMUSP00000005352 Ensembl | MGI Sequence Detail 1113 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 11
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141119
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 27
      Gene Ontology 11
      Phenotypes 41
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:339589 Sibony-Benyamini H, et al., Hdac1 and Hdac2 regulate the quiescent state and survival of hair-follicle mesenchymal niche. Nat Commun. 2023 Aug 10;14(1):4820
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory