Scamp1 MGI Mouse Gene Detail - MGI:1349480 - secretory carrier membrane protein 1

Symbol

Scamp1
Name

secretory carrier membrane protein 1
Synonyms

4930505M11Rik

Feature Type

protein coding gene
IDs

MGI:1349480
NCBI Gene: 107767
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr13:94337818-94422339 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 49.22 cM, cytoband D1
Mapping Data

4 experiments

SNPs within 2kb

2341 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1349480	protein coding gene	Chr13:94337818-94422365 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020831	protein coding gene	Chr13:95608650-95692583 (-)
A/J	MGP_AJ_G0020785	protein coding gene	Chr13:92027690-92107055 (-)
AKR/J	MGP_AKRJ_G0020759	protein coding gene	Chr13:94845194-94920296 (-)
BALB/cJ	MGP_BALBcJ_G0020782	protein coding gene	Chr13:92693771-92777966 (-)
C3H/HeJ	MGP_C3HHeJ_G0020575	protein coding gene	Chr13:94555284-94635355 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021218	protein coding gene	Chr13:98521217-98608501 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018787	protein coding gene	Chr13:87875650-87954049 (-)
CAST/EiJ	MGP_CASTEiJ_G0020094	protein coding gene	Chr13:93792822-93872433 (-)
CBA/J	MGP_CBAJ_G0020534	protein coding gene	Chr13:102447293-102537356 (-)
DBA/2J	MGP_DBA2J_G0020659	protein coding gene	Chr13:91826078-91901824 (-)
FVB/NJ	MGP_FVBNJ_G0020640	protein coding gene	Chr13:90607398-90690585 (-)
LP/J	MGP_LPJ_G0020734	protein coding gene	Chr13:95706342-95799299 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020668	protein coding gene	Chr13:102903042-102988908 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021258	protein coding gene	Chr13:94239723-94320344 (-)
PWK/PhJ	MGP_PWKPhJ_G0019846	protein coding gene	Chr13:90545261-90621220 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019670	protein coding gene	Chr13:90498945-90583201 (-)
WSB/EiJ	MGP_WSBEiJ_G0020151	protein coding gene	Chr13:94727476-94804634 (-)

Human Ortholog

SCAMP1, secretory carrier membrane protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SCAMP1, secretory carrier membrane protein 1
Synonyms

SCAMP, SCAMP37
Links

HGNC:10563

NCBI Gene ID: 9522

neXtProt AC: NX_O15126

UniProt: O15126
Chr Location

5q14.1; chr5:78360611-78480739 (+) GRCh38

MGI Vertebrate Homology

Scamp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SCAMP1
Gene Tree

Scamp1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Targeted

3
Genomic Mutations

1 involving Scamp1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available

Mice homozygous for a targeted null mutation do not exhibit any overt abnormalities, but final cell capacitance of mast cells completing exocytosis was smaller than controls and an increased proportion of reversible fusion events was noted.

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All GO Annotations

26
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

6
cDNA Data

13
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase scamp1

ZFIN scamp1

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All Sequences

63
RefSeq

10
UniProt

7
CCDS

CCDS36750.1, CCDS84049.1

Ensembl

ENSMUSG00000021687 (Evidence)
NCBI Gene

107767

			Length	Strain/Species	Flank
genomic	107767	NCBI Gene Model \| MGI Sequence Detail	84522	C57BL/6J	± kb
transcript	NM_001346609	RefSeq \| MGI Sequence Detail	3915	C57BL/6
polypeptide	Q8K021	UniProt \| EBI \| MGI Sequence Detail	338	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000014483 secretory carrier-associated membrane protein 1

(term hierarchy)
InterPro Domains

IPR007273 SCAMP
GlyGen

Q8K021 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 14

cDNA 14

Microarray probesets 5

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MGI:1922292, MGI:2145229, MGI:2145416

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 8
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:262823 Kasowitz SD, et al., Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development. PLoS Genet. 2018 May;14(5):e1007412

TSS for Scamp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr123485	Chr13:94422501-94422528 (-)	-176 bp
Tssr123484	Chr13:94422401-94422409 (-)	-66 bp
Tssr123483	Chr13:94421860-94421949 (-)	434 bp
Tssr123482	Chr13:94421789-94421850 (-)	519 bp
Tssr123481	Chr13:94415555-94415559 (-)	6,782 bp
Tssr123480	Chr13:94395194-94395214 (-)	27,135 bp
Tssr123479	Chr13:94389548-94389578 (-)	32,776 bp
Tssr123478	Chr13:94383089-94383104 (-)	39,242 bp
Tssr123477	Chr13:94383040-94383081 (-)	39,278 bp
Tssr123476	Chr13:94382081-94382093 (-)	40,252 bp
Tssr123475	Chr13:94340091-94340119 (-)	82,234 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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