Cul1 MGI Mouse Gene Detail - MGI:1349658

Symbol

Cul1
Name

cullin 1

Feature Type

protein coding gene
IDs

MGI:1349658
NCBI Gene: 26965
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr6:47430516-47503078 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 22.90 cM, cytoband B3
Mapping Data

1 experiment

SNPs within 2kb

1062 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1349658	protein coding gene	Chr6:47430332-47503078 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030681	protein coding gene	Chr6:46344483-46421182 (+)
A/J	MGP_AJ_G0030653	protein coding gene	Chr6:44196145-44273500 (+)
AKR/J	MGP_AKRJ_G0030578	protein coding gene	Chr6:45719631-45793355 (+)
BALB/cJ	MGP_BALBcJ_G0030663	protein coding gene	Chr6:44550771-44625269 (+)
C3H/HeJ	MGP_C3HHeJ_G0030376	protein coding gene	Chr6:45763824-45844732 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031118	protein coding gene	Chr6:47461054-47538479 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028324	protein coding gene	Chr6:41920166-41995071 (+)
CAST/EiJ	MGP_CASTEiJ_G0029780	protein coding gene	Chr6:45620484-45694415 (+)
CBA/J	MGP_CBAJ_G0030351	protein coding gene	Chr6:49360508-49443090 (+)
DBA/2J	MGP_DBA2J_G0030500	protein coding gene	Chr6:44146381-44219633 (+)
FVB/NJ	MGP_FVBNJ_G0030452	protein coding gene	Chr6:43779038-43854878 (+)
LP/J	MGP_LPJ_G0030584	protein coding gene	Chr6:46250755-46325760 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030486	protein coding gene	Chr6:52252855-52333008 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031147	protein coding gene	Chr6:45661497-45738938 (+)
PWK/PhJ	MGP_PWKPhJ_G0029492	protein coding gene	Chr6:43778270-43850672 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029328	protein coding gene	Chr6:45195081-45266781 (+)
WSB/EiJ	MGP_WSBEiJ_G0029856	protein coding gene	Chr6:45641727-45716824 (+)

Human Ortholog

CUL1, cullin 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CUL1, cullin 1
Links

HGNC:2551

NCBI Gene ID: 8454

neXtProt AC: NX_Q13616

UniProt: Q13616
Chr Location

7q36.1; chr7:148697756-148801110 (+) GRCh38

MGI Vertebrate Homology

Cul1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CUL1
Gene Tree

Cul1

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Phenotype Summary

6 phenotypes from 2 alleles in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

64
Endonuclease-mediated

2
Gene trapped

60
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

58 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations accumulate cyclin E1 and exhibit arrested development and lethality around embryonic day 6.5.

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All GO Annotations

38
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

784
Tissues

41
cDNA Data

14
Literature Summary

15

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cul1

ZFIN cul1a, cul1b

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All Sequences

78
RefSeq

14
UniProt

7
CCDS

CCDS20095.1

Ensembl

ENSMUSG00000029686 (Evidence)
NCBI Gene

26965

			Length	Strain/Species	Flank
genomic	26965	NCBI Gene Model \| MGI Sequence Detail	72563	C57BL/6J	± kb
transcript	NM_001355550	RefSeq \| MGI Sequence Detail	3434	C57BL/6
polypeptide	Q9WTX6	UniProt \| EBI \| MGI Sequence Detail	776	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000000092 fungal/metazoan cullin-1

(term hierarchy)
InterPro Domains

IPR045093 Cullin

IPR016157 Cullin, conserved site

IPR016158 Cullin homology domain

IPR036317 Cullin homology domain superfamily

IPR001373 Cullin, N-terminal

IPR019559 Cullin protein, neddylation domain

IPR016159 Cullin repeat-like-containing domain superfamily

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily
GlyGen

Q9WTX6 1 site, 1 O-linked glycan (1 site)

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All nucleic 15

cDNA 15

Microarray probesets 4

Summaries

All 71

Developmental Gene Expression 15

Gene Ontology 14

Phenotypes 8
Earliest

J:48258 Michel JJ, et al., Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A. Cell Growth Differ. 1998 Jun;9(6):435-49
Latest

J:335720 Li R, et al., Interaction between dual specificity phosphatase-1 and cullin-1 attenuates alcohol-related liver disease by restoring p62-mediated mitophagy. Int J Biol Sci. 2023;19(6):1831-1845

TSS for Cul1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56078	Chr6:47430765-47430802 (+)	268 bp
Tssr56079	Chr6:47430808-47430841 (+)	309 bp
Tssr56080	Chr6:47430847-47430863 (+)	339 bp
Tssr56081	Chr6:47430888-47430926 (+)	391 bp
Tssr56082	Chr6:47430940-47430951 (+)	430 bp
Tssr56083	Chr6:47431274-47431357 (+)	800 bp
Tssr56084	Chr6:47431367-47431379 (+)	857 bp
Tssr56085	Chr6:47431616-47431635 (+)	1,110 bp
Tssr56086	Chr6:47431636-47431653 (+)	1,129 bp
Tssr56087	Chr6:47431919-47431928 (+)	1,408 bp
Tssr56088	Chr6:47431933-47431942 (+)	1,422 bp
Tssr56089	Chr6:47445063-47445066 (+)	14,549 bp
Tssr56090	Chr6:47445284-47445289 (+)	14,771 bp
Tssr56091	Chr6:47457721-47457728 (+)	27,209 bp
Tssr56092	Chr6:47487108-47487109 (+)	56,593 bp
Tssr56093	Chr6:47499266-47499270 (+)	68,752 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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