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Spo11 Gene Detail
Summary
  • Symbol
    Spo11
  • Name
    SPO11 initiator of meiotic double stranded breaks
  • Synonyms
    Spo11a, Spo11b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349669
    NCBI Gene: 26972
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:172819493-172835369 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 95.64 cM, cytoband H4
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    620 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349669
 protein coding gene Chr2:172819172-172835369 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026950
 protein coding gene Chr2:179216876-179234530 (+)
A/J MGP_AJ_G0026917
 protein coding gene Chr2:171684655-171700532 (+)
AKR/J MGP_AKRJ_G0026888
 protein coding gene Chr2:176858847-176877746 (+)
BALB/cJ MGP_BALBcJ_G0026926
 protein coding gene Chr2:172084539-172100744 (+)
C3H/HeJ MGP_C3HHeJ_G0026668
 protein coding gene Chr2:177242280-177258148 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027373
 protein coding gene Chr2:184371378-184388638 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024743
 protein coding gene Chr2:164926283-164941557 (+)
CAST/EiJ MGP_CASTEiJ_G0026126
 protein coding gene Chr2:177939382-177956687 (+)
CBA/J MGP_CBAJ_G0026645
 protein coding gene Chr2:191278053-191293962 (+)
DBA/2J MGP_DBA2J_G0026783
 protein coding gene Chr2:170781698-170797595 (+)
FVB/NJ MGP_FVBNJ_G0026749
 protein coding gene Chr2:169399045-169415048 (+)
LP/J MGP_LPJ_G0026884
 protein coding gene Chr2:179154985-179172263 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026768
 protein coding gene Chr2:194222234-194238066 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027430
 protein coding gene Chr2:176872998-176888697 (+)
PWK/PhJ MGP_PWKPhJ_G0025863
 protein coding gene Chr2:170573470-170589495 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025663
 protein coding gene Chr2:175864870-175882914 (+)
WSB/EiJ MGP_WSBEiJ_G0026199
 protein coding gene Chr2:177830068-177845738 (+)



Homology
more
  • Human Ortholog
    SPO11, SPO11 initiator of meiotic double strand breaks
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPO11, SPO11 initiator of meiotic double strand breaks
  • Synonyms
    CT35, SPATA43, TOPOVIA, TOPVIA
  • Links
    NCBI Gene ID: 23626
    neXtProt AC: NX_Q9Y5K1
    UniProt: Q9Y5K1

  • Chr Location
    20q13.31; chr20:57329803-57343994 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 8 alleles in 12 genetic backgrounds
    15 phenotypes from multigenic genotypes
    4 images
    102 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout affects double-stranded breaks in male meiosis causing loss of spermatocytes in early prophase and sterility, while mutant females exhibit oocyte loss soon after birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    831
  • Tissues
    26
  • cDNA Data
    12
  • Literature Summary
    30
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005883 Ensembl Gene Model | MGI Sequence Detail 15877 C57BL/6J ±  kb
    transcript ENSMUST00000050442 Ensembl | MGI Sequence Detail 1709 Not Applicable  
    polypeptide ENSMUSP00000059056 Ensembl | MGI Sequence Detail 396 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 2
      cDNA 12
      Primer pair 9
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138956
    References
    more
    • Summaries
      All 157
      Developmental Gene Expression 30
      Gene Ontology 15
      Phenotypes 102
    • Earliest
      J:58262 Romanienko PJ, et al., Cloning, characterization, and localization of mouse and human SPO11. Genomics. 1999 Oct 15;61(2):156-69
    • Latest
      J:348825 Bai L, et al., BRCA1 safeguards genome integrity by activating chromosome asynapsis checkpoint to eliminate recombination-defective oocytes. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2401386121
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory